Manish K. Sethi
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View article: Peripheral Nerve Stimulator-Guided Regional Anaesthesia for Modified Radical Mastectomy in High-Risk Patients – A Case Series
Peripheral Nerve Stimulator-Guided Regional Anaesthesia for Modified Radical Mastectomy in High-Risk Patients – A Case Series Open
Thoracic paravertebral block (TPVB) is an effective and time-tested regional anesthesia (RA) technique of anesthesia/analgesia for breast surgeries. It can be performed by landmark guided, peripheral nerve stimulator (PNS) guided or ultras…
View article: Combating Airway Issues with Elective Use of an I Gel in a Child with Goldenhar Syndrome
Combating Airway Issues with Elective Use of an I Gel in a Child with Goldenhar Syndrome Open
Introduction: Goldenhar syndrome is an oculoauriculovertebral spectrum attributed to the developmental anomalies of the first and second brachial arches. Its typical presentation in children with hemifacial microsomia poses a dual challeng…
View article: Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity
Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity Open
We demonstrate proof of principle that nanoparticle delivery of chemosensitizers can improve efficacy of chemotherapy without increasing toxicity.
View article: Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery
Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery Open
Radiotherapy is a key component of cancer treatment. Because of its importance, there has been high interest in developing agents and strategies to further improve the therapeutic index of radiotherapy. DNA double-strand repair inhibitors …
View article: Differential cell responses to nanoparticle docetaxel and small molecule docetaxel at a sub-therapeutic dose range
Differential cell responses to nanoparticle docetaxel and small molecule docetaxel at a sub-therapeutic dose range Open
Current preclinical evaluations of nanoparticle taxanes have focused on the effect of nanoparticle size and shape on the efficacy and toxicity. It is generally assumed that nanoparticle therapeutics have the same cellular response on tumor…
View article: Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity
Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity Open
Nanoparticles’ drug release kinetics can directly affect their therapeutic efficacy and toxicity.
View article: Preclinical Evaluation of Genexol-PM, a Nanoparticle Formulation of Paclitaxel, as a Novel Radiosensitizer for the Treatment of Non-Small Cell Lung Cancer
Preclinical Evaluation of Genexol-PM, a Nanoparticle Formulation of Paclitaxel, as a Novel Radiosensitizer for the Treatment of Non-Small Cell Lung Cancer Open
A key research objective in radiation oncology is to identify agents that can improve chemoradiation therapy. Nanoparticle (NP) chemotherapeutics possess several properties, such as preferential accumulation in tumors, that are uniquely su…
View article: Acceptability and feasibility of an innovative anesthesia technique in a low-resource setting at a rural community ophthalmic center: A prospective journey
Acceptability and feasibility of an innovative anesthesia technique in a low-resource setting at a rural community ophthalmic center: A prospective journey Open
Intravenous ketamine is an inexpensive and safe anesthetic technique when used in conjunction with regional block and is certainly a boon for minimal resource ophthalmic setup in rural India.
View article: Association Between 6-Week Postdischarge Risk Classification and 12-Month Outcomes After Orthopedic Trauma
Association Between 6-Week Postdischarge Risk Classification and 12-Month Outcomes After Orthopedic Trauma Open
This study demonstrates that during early recovery, patients with orthopedic trauma can be classified into risk and protective clusters that account for a substantial amount of the variance in 12-month functional and health outcomes. Early…
View article: Patients at Increased Risk of Major Adverse Events Following Operative Treatment of Distal Radius Fractures: Inpatient versus Outpatient
Patients at Increased Risk of Major Adverse Events Following Operative Treatment of Distal Radius Fractures: Inpatient versus Outpatient Open
Purpose The purpose of this study was to compare complication rates following inpatient versus outpatient distal radius fracture ORIF and identify specific complications that occur at increased rates among inpatients. Methods Using the 200…