Explanipedia

Indian clinical practice consensus guidelines for the management of nasopharyngeal cancer – Update 2024 Open

HS Darling, Vanita Noronha, Govind Babu, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2025

Nasopharyngeal carcinoma is a rare malignancy that poses significant treatment challenges, particularly in the context of curative intent. This updated guideline consolidates contemporary evidence and clinical practices tailored to the Ind…

Indian clinical practice consensus guidelines for the management of oropharyngeal cancer – Update 2024 Open

Vanita Noronha, Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2025

Oropharyngeal cancer typically presents at a nonmetastatic stage and is mostly treated with curative intent. Although surgical options are available, they are often associated with significant functional and cosmetic morbidity, leading to …

Indian clinical practice consensus guidelines for the management of locoregional laryngeal cancer – Update 2024 Open

Manish Singhal, K Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2025

Laryngeal cancer typically presents at an early stage, and most patients are treated with curative intent. Due to the functional and cosmetic morbidities associated with surgical approaches, nonsurgical modalities are increasingly favored.…

Indian clinical practice consensus guidelines for the management of recurrent, persistent, or metastatic squamous cell carcinoma of head-and-neck – Update 2024 Open

Vanita Noronha, K. Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2025

Head-and-neck squamous cell carcinoma (HNSCC) remains a significant public health concern, particularly in India, where its incidence is disproportionately high due to risk factors such as tobacco and alcohol use. The updated guidelines fo…

Indian clinical practice consensus guidelines for the management of oral cavity cancer – Update 2024 Open

Pankaj Chaturvedi, HS Darling, Govind Babu, Vanita Noronha, Moni Abraham Kuriakose , et al. · 2025

Squamous cell carcinoma is the predominant cancer of the oral cavity. Oral cavity cancer (OCC) typically presents at an early stage. Almost all patients are treated with curative intent. Surgical approaches are the mainstay of treatment, a…

Indian clinical practice consensus guidelines for the management of locoregional hypopharyngeal cancer – Update 2024 Open

HS Darling, K Govind Babu, Vanita Noronha, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2025

Hypopharyngeal cancer usually presents at the locally advanced stage and is relatively uncommon. Early diagnosis is difficult because of recesses and spaces around the larynx, which delay presentation until local progression or neck metast…

Safety and Efficacy Assessment of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2‐Positive Unresectable Locally Advanced or Metastatic Breast Cancer Previously Treated With Trastuzumab and a Taxane: An Open‐Label, Single‐Arm, Phase IV Study Open

Sudeep Gupta, Manish Singhal, Shona Nag, Waseem Abbas, Dinesh Chandra Doval , et al. · 2025

Introduction Trastuzumab emtansine (T‐DM1), an antibody–drug conjugate, targets tumor cells overexpressing human epidermal growth factor receptor 2 (HER2). This single‐arm, phase IV study assessed the safety and efficacy of T‐DM1 in Indian…

48P Distinguishing genomic markers of therapy resistance and aggressive tumor growth using comprehensive genomic profiling for targeting molecular vulnerabilities in solid tumors Open

Nikhil Ghadyalpatil, Aarthi Ramesh, Atul Bharde, Kanchan Hariramani, Sandhya Iyer , et al. · 2025

Indian clinical practice consensus guidelines for the management of locoregional laryngeal cancer - Update 2023 Open

Manish Singhal, K Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Laryngeal cancer typically presents at a nonmetastatic stage, and the majority of patients are treated with curative intent. Due to the functional and cosmetic morbidities associated with surgical approaches, nonsurgical modalities are inc…

Indian clinical practice consensus guidelines for the management of locoregional hypopharyngeal cancer - Update 2023 Open

HS Darling, K Govind Babu, Vanita Noronha, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Hypopharyngeal cancer usually presents at a locally advanced stage. Almost all patients are treated with a curative intent. As surgical approaches are functionally and cosmetically morbid, nonsurgical modalities are preferred. This review …

Indian clinical practice consensus guidelines for the management of oropharyngeal cancer - Update 2023 Open

Vanita Noronha, Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Oropharyngeal cancer typically presents at a nonmetastatic stage and is primarily treated with curative intent. While surgical options are available, they are often associated with significant functional and cosmetic morbidity, leading to …

Indian clinical practice consensus guidelines for the management of oral cavity cancer - Update 2023 Open

HS Darling, K. Govind Babu, Vanita Noronha, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Oral cavity cancer (OCC) essentially presents at a non-metastatic stage. Almost all patients are treated with a curative intent. Surgical approaches are the mainstay of treatment accompanied by radiotherapy and chemotherapy where applicabl…

Indian clinical practice consensus guidelines for the management of nasopharyngeal cancer - Update 2023 Open

HS Darling, Vanita Noronha, Govind Babu, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Nasopharyngeal carcinoma (NPC) is a rare malignancy that poses significant treatment challenges, particularly in the context of curative intent. This updated guideline consolidates contemporary evidence and clinical practices tailored to t…

Indian clinical practice consensus guidelines for the management of recurrent, persistent, or metastatic squamous cell carcinoma of head-and-neck - Update 2023 Open

Vanita Noronha, K. Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Head-and-neck squamous cell carcinoma (HNSCC) remains a significant public health concern, particularly in India, where its incidence is disproportionately high due to risk factors such as tobacco and alcohol use. The updated guidelines fo…

Adjuvant Chemotherapy in Colon Cancer: Simple is Better… Less is More Open

Prasad Narayanan, Shyam Aggarwal, Manish Singhal, Vamshi Krishna, A. K. Rathi , et al. · 2024

A significant number of patients with colorectal cancer (CRC) benefit from adjuvant therapy. While 6 months of FOLFOX is standard of care, newer regimens like CAPOX and SOX allow for shorter durations. Trials of importance include SCOT (U.…

Indian clinical practice consensus guidelines for the management of laryngeal cancer: Update 2022 Open

Manish Singhal, Kumar Prabhash, K Govind Babu, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

In laryngeal cancer, the goal of treatment is to achieve maximum cure and preserve function of the larynx with good voice quality. In early disease, transoral laser microsurgery is the preferred choice of treatment. An option for treatment…

Indian clinical practice consensus guidelines for the management of very advanced head-and-neck squamous cell carcinoma: Update 2022 Open

Vanita Noronha, Kumar Prabhash, K. Govind Babu, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

The management of recurrent or metastatic head-and-neck cancers is evolving. Promising novel immunotherapies and targeted therapies have led to a paradigm shift in the management of very advanced disease. Single-agent systemic therapy incl…

Introduction to Indian clinical practice consensus guidelines for the management of squamous cell carcinoma the head-and-neck: Update 2022 Open

Vanita Noronha, Kumar Prabhash, K. Govind Babu, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Head-and-neck cancer (HNC), a malignant tumor of the upper aerodigestive tract, is the sixth most common cancer worldwide. In India, around 30-40% of all cancers are HNCs. Even though there are global guidelines and recommendations for the…

Indian clinical practice consensus guidelines for the management of oropharyngeal cancer: Update 2022 Open

Vanita Noronha, Kumar Prabhash, K Govind Babu, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

The aim of oropharyngeal cancer treatment should be to treat the disease while preserving speech and swallowing abilities. Early-stage disease is generally treated with surgery/radiotherapy (RT). A combination of chemotherapy and RT should…

Indian clinical practice consensus guidelines for the management of oral cavity cancer: Update 2022 Open

Pankaj Chaturvedi, Kumar Prabhash, Govind Babu, Moni Abraham Kuriakose, Praveen Birur , et al. · 2024

The treatment of oral cavity cancer primarily depends on the location, tumor size, and feasibility of organ preservation in patients with negative margins. A liquid biopsy is a minimally invasive approach for detecting blood-based signatur…

Indian clinical practice consensus guidelines for the management of nasopharyngeal cancer: Update 2022 Open

Munish Gairola, Kumar Prabhash, K. Govind Babu, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Patients with early-stage nasopharyngeal cancer are treated with definitive radiotherapy alone, including both sides of the neck and retropharyngeal nodes. For patients with locoregionally advanced nasopharyngeal cancer, the recommendation…

Indian clinical practice consensus guidelines for the management of hypopharyngeal cancer: Update 2022 Open

K. Govind Babu, Kumar Prabhash, Pankaj Chaturvedi, Moni Abraham Kuriakose, Praveen Birur , et al. · 2024

In early hypopharyngeal cancer, definitive radiotherapy (RT) is the preferred modality of treatment. The surgical treatment options are transoral laser microsurgery with selective neck dissection or a partial laryngopharyngectomy plus neck…

Multimodality Management of Two Pairs of Pyopagus Twins Open

Minu Bajpai, Mehak Sehgal, Deepak Yadav, Apoorv Singh, Prabudh Goel , et al. · 2023

Background and Aim: Conjoined twins, due to their rarity and complex anatomy, pose not only a technical, but also a physiological challenge for their separation, with each case being uniquely distinct. The aim of the present article is to …

The Urological Society of India guidelines for the evaluation and management of prostate cancer (executive summary) Open

Anup Kumar, Siddharth Yadav, R. Krishnappa, Gagan Gautam, N Raghavan , et al. · 2022

prospective study to assess the clinical, cytological and histopathological findings of salivary gland lesions Open

Nidhi Priya, Madhuri Agarwal, Kamlesh Yadav, Manish Singhal · 2022

Background: The purpose of FNAC is not only to provide a definite specific diagnosis. But it is also used in conjunction with clinical and radiological findings to provide the best possible initial assessment from which management can be p…

Increased Notification of Tuberculosis Cases and MDR andXDR Cases Post Introduction of CBNAAT in Rajasthan: A Retrospective Case Study of 4 Years from 2015-2018 Open

Neil Sharma, Manish Singhal, Rachana Agrawal, Manoj Kumar Sharma, Sona Goyal · 2021

Context: Tuberculosis is a major health problem in India .Accurate and also fast diagnosis of tuberculosis has remained a challenge and we determined the impact of CBNAAT on notification of tuberculosis cases in Rajasthan. Aims: The Aim of…

Clinico-Radiological Outcome after Surgical Interventions in Ankle Fractures at a Tertiary Care Centre in Moradabad, Uttar Pradesh Open

Amit Saraf, Manish Singhal, Najmul Huda · 2021

BACKGROUND Ankle fractures are among the most common injuries encountered by orthopaedic surgeons. An ankle is considered unstable when the loss of normal constraints around the ankle permits the talus to move in a non-physiologic pattern.…

ASSOCIATION OF CELIAC DISEASES WITH SEVERE ACUTE MALNUTRITION CHILDREN, AT TERTIARY CARE CENTRE: - A PROSPECTIVE STUDY Open

Sameer Jagrwal, Pooja Sharma, Kapil Shrimali, Prasun Bhattacharjee, Manish Singhal · 2021

Introduction: Celiac disease (CD) may be an underlying cause of malnutrition. Aim: The objective of this study was to find out the seroprevalence of CD in children suffering from severe acute malnutrition (SAM) in age group of 1–5 years.…

ROLE OF GLUTEN FREE DIET IN CELIAC DISEASE WITH CHILDREN SUFFERING FROM SEVERE ACUTE MALNUTRITION. Open

Sameer Jagrwal, Vivek Sharma, Gourav Goyal, Prasun Bhattacharjee, Manish Singhal · 2021

Background: Diagnosis of celiac disease in children suffering from severe acute malnutrition without duodenal biopsy or HLA typing is a dilemma. The objective of this study was to study the response to gluten free diet in sero-positive Cel…

Genetic Counseling, Testing, and Management of HBOC in India: An Expert Consensus Document from Indian Society of Medical and Pediatric Oncology Open

Hemant Malhotra, Pradnya Kowtal, Nikita Mehra, Raja Pramank, Rajiv Sarin , et al. · 2020

PURPOSE Hereditary breast and ovarian cancer (HBOC) syndrome is primarily characterized by mutations in the BRCA1/2 genes. There are several barriers to the implementation of genetic testing and counseling in India that may affect clinical…

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