Manjit S. Bains
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View article: The role of diagnostic laparoscopy in staging distal esophageal adenocarcinoma
The role of diagnostic laparoscopy in staging distal esophageal adenocarcinoma Open
View article: Should minimally invasive surgery be the standard approach for early-stage thymoma? A 20-year experience
Should minimally invasive surgery be the standard approach for early-stage thymoma? A 20-year experience Open
View article: Figure S3 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Figure S3 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Figure S3. Other variables significantly associated with pathologic major response to neoadjuvant therapy, including (A) clinical stage, (B) treatment regimen, (C) tumor grade, and (D) tumor location. (E) Relative contributio…
View article: Figure S2 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Figure S2 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Figure S2. Overall survival comparisons by molecular subtype of the (A) palliative-intent, (B) curative-intent, (C) never-immunotherapy, and (D) ever-immunotherapy cohorts. CIN, chromosomally instable; EBV, Epstein-Barr virus…
View article: Supplementary Methods1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Supplementary Methods1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Methods
View article: Supplementary Tables1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Supplementary Tables1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Tables
View article: Figure S1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Figure S1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Figure S1. (A) Fraction of genome altered, (B) clinical actionability as defined by OncoKB by molecular subtype, and (C) tumor mutational burden. CIN, chromosomally instable; EBV, Epstein-Barr virus associated; GS, genomicall…
View article: Figure S3 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Figure S3 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Figure S3. Other variables significantly associated with pathologic major response to neoadjuvant therapy, including (A) clinical stage, (B) treatment regimen, (C) tumor grade, and (D) tumor location. (E) Relative contributio…
View article: Figure S1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Figure S1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Figure S1. (A) Fraction of genome altered, (B) clinical actionability as defined by OncoKB by molecular subtype, and (C) tumor mutational burden. CIN, chromosomally instable; EBV, Epstein-Barr virus associated; GS, genomicall…
View article: Supplementary Methods1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Supplementary Methods1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Methods
View article: Supplementary Tables1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Supplementary Tables1 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Tables
View article: Figure S2 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Figure S2 from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Supplementary Figure S2. Overall survival comparisons by molecular subtype of the (A) palliative-intent, (B) curative-intent, (C) never-immunotherapy, and (D) ever-immunotherapy cohorts. CIN, chromosomally instable; EBV, Epstein-Barr virus…
View article: Data from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer
Data from Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer Open
Purpose:The Cancer Genome Atlas (TCGA) project defined four distinct molecular subtypes of esophagogastric adenocarcinoma: microsatellite instable (MSI), Epstein–Barr virus (EBV)–associated, genomically stable (GS), and chromosomally insta…
View article: A Novel Frailty Index Can Predict the Short-Term Outcomes of Esophagectomy in Older Patients with Esophageal Cancer
A Novel Frailty Index Can Predict the Short-Term Outcomes of Esophagectomy in Older Patients with Esophageal Cancer Open
Background: Frailty, rather than age, is associated with postoperative morbidity and mortality. We sought to determine whether preoperative frailty as defined by a novel scoring system could predict the outcomes among older patients underg…
View article: Biologic versus synthetic prosthesis for chest wall reconstruction: a matched analysis
Biologic versus synthetic prosthesis for chest wall reconstruction: a matched analysis Open
OBJECTIVES The aim of this study was to compare postoperative outcomes between biologic and synthetic reconstructions after chest wall resection in a matched cohort. METHODS All patients who underwent reconstruction after full-thickness ch…
View article: Superior sulcus non–small cell lung cancers (Pancoast tumors): Current outcomes after multidisciplinary management
Superior sulcus non–small cell lung cancers (Pancoast tumors): Current outcomes after multidisciplinary management Open
View article: Prognostic value of circumferential radial margin involvement in esophagectomy for esophageal cancer: a case series
Prognostic value of circumferential radial margin involvement in esophagectomy for esophageal cancer: a case series Open
Background: Residual tumor at the proximal or distal margin after esophagectomy is associated with worse survival outcomes; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, we so…
View article: The contribution of microvascular free flaps and pedicled flaps to successful chest wall surgery
The contribution of microvascular free flaps and pedicled flaps to successful chest wall surgery Open
View article: A Prospective Clinical Trial to Evaluate Mesothelin as a Biomarker for the Clinical Management of Patients With Esophageal Adenocarcinoma
A Prospective Clinical Trial to Evaluate Mesothelin as a Biomarker for the Clinical Management of Patients With Esophageal Adenocarcinoma Open
Objective: To investigate the utility of serum soluble mesothelin-related peptide (SMRP) and tumor mesothelin expression in the management of esophageal adenocarcinoma (ADC). Background: Clinical management of esophageal ADC is limited by …
View article: Table of contents
Table of contents Open
View article: Figure S4 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Figure S4 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
CONSORT diagram of sample flow and sequencing success rates.
View article: Tables S1-S5 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Tables S1-S5 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
Supplementary Table 1: Comprehensive clinical data and sample IDs. Supplementary Table 2: Summary of baseline patient and sample characteristics. Supplementary Table 3: List of somatic mutations identified in all samples. Supplementary Tab…
View article: Figure S2 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Figure S2 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
Concordance between copy-number inferred from next generation sequencing and protein overexpression by IHC or gene amplification by FISH.
View article: Data from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Data from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
The incidence of esophagogastric cancer is rapidly rising, but only a minority of patients derive durable benefit from current therapies. Chemotherapy as well as anti-HER2 and PD-1 antibodies are standard treatments. To identify predictive…
View article: Supplementary Figure Legends from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Supplementary Figure Legends from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
Text legends for Supplementary Figures S1-S4.
View article: Figure S1 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Figure S1 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
Comparison of mutation frequencies in non-MSI-H tumors in the MSK cohort vs. TCGA and comparison of mutation frequencies in primary vs. metastatic samples in the MSK cohort.
View article: Figure S3 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Figure S3 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
Alteration patterns of paired pre- vs post-treatment samples from HER2 positive patients treated with trastuzumab.
View article: Supplementary Figure Legends from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Supplementary Figure Legends from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
Text legends for Supplementary Figures S1-S4.
View article: Figure S4 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Figure S4 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
CONSORT diagram of sample flow and sequencing success rates.
View article: Tables S1-S5 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Tables S1-S5 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer Open
Supplementary Table 1: Comprehensive clinical data and sample IDs. Supplementary Table 2: Summary of baseline patient and sample characteristics. Supplementary Table 3: List of somatic mutations identified in all samples. Supplementary Tab…