Minesh P. Mehta
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View article: Evaluation of Patients Perspectives on Dental Implants and Bone Graft Surgery
Evaluation of Patients Perspectives on Dental Implants and Bone Graft Surgery Open
A BSTRACT Aim: To evaluate patient’s perspective on dental implants and bone grafts. Materials and Methods: A series of 50 consecutive patients looking for implant treatment were included in the city. Patients who had past history of impla…
View article: TIP-11. MOMENTUM-1: a multicenter, randomized, open-label, phase 2 study of [177Lu]Lu-DOTA-TATE in adults with progressive grade 1-3 meningioma (RTOG 3523)
TIP-11. MOMENTUM-1: a multicenter, randomized, open-label, phase 2 study of [177Lu]Lu-DOTA-TATE in adults with progressive grade 1-3 meningioma (RTOG 3523) Open
BACKGROUND While most meningiomas are classified as low-grade tumors with indolent behavior, a subset is characterized by a more aggressive clinical course and patients undergo repeated resections and courses of radiation. Once these thera…
View article: RADT-33. PROGNOSTIC AND PREDICTIVE EFFECT OF AGE IN MOLECULARLY-DEFINED LOWER GRADE GLIOMAS: A REPORT FROM THE PROSPECTIVE GLIOMA RESEARCH (PROGRES) DATABASE
RADT-33. PROGNOSTIC AND PREDICTIVE EFFECT OF AGE IN MOLECULARLY-DEFINED LOWER GRADE GLIOMAS: A REPORT FROM THE PROSPECTIVE GLIOMA RESEARCH (PROGRES) DATABASE Open
PURPOSE Age over 40 years is commonly regarded as a “high risk” feature and potential indication for adjuvant chemoradiotherapy for patients with lower grade glioma in most clinical practice guidelines. However, these recommendations are b…
View article: CTNI-29. MOLECULAR ANALYSIS OF OUTCOMES IN ECOG-ACRIN E3F05: PHASE III STUDY OF RADIATION THERAPY WITH OR WITHOUT TEMOZOLOMIDE FOR SYMPTOMATIC OR PROGRESSIVE LOW-GRADE GLIOMAS
CTNI-29. MOLECULAR ANALYSIS OF OUTCOMES IN ECOG-ACRIN E3F05: PHASE III STUDY OF RADIATION THERAPY WITH OR WITHOUT TEMOZOLOMIDE FOR SYMPTOMATIC OR PROGRESSIVE LOW-GRADE GLIOMAS Open
BACKGROUND The phase III ECOG-ACRIN E3F05 trial tested whether combined therapy with radiation and concomitant followed by adjuvant temozolomide is more effective than radiation alone in patients with grade II gliomas. The study incorporat…
View article: BIOM-23. EVALUATING THE MOLECULAR CONCORDANCE BETWEEN LIQUID BIOPSY AND BRAIN METASTASIS TISSUE IN PATIENTS WITH BRAIN METASTASES
BIOM-23. EVALUATING THE MOLECULAR CONCORDANCE BETWEEN LIQUID BIOPSY AND BRAIN METASTASIS TISSUE IN PATIENTS WITH BRAIN METASTASES Open
BACKGROUND Management of patients with brain metastases requires knowledge of the molecular profile of the disease. Although molecular discordance between systemic disease and brain metastases is recognized, the extent to which peripheral …
View article: Redefining neurocognitive outcomes after radiation for brain metastases: a patient-level meta-analysis of recovery following initial decline
Redefining neurocognitive outcomes after radiation for brain metastases: a patient-level meta-analysis of recovery following initial decline Open
Background Although there are data describing the onset of neurocognitive toxicity following radiation for patients with brain metastases, less is known about the potential for functional cognitive recovery (CR). This study sought to evalu…
View article: Intracranial metastases from solid tumors: Call to Action and Consensus from the Society for Neuro-Oncology and American Society of Clinical Oncology Collaborative
Intracranial metastases from solid tumors: Call to Action and Consensus from the Society for Neuro-Oncology and American Society of Clinical Oncology Collaborative Open
Intracranial metastases (ICM), specifically parenchymal brain metastases, remain a major clinical challenge in solid tumor oncology, despite recent advances in cancer therapies which have led to improvements in survival for these patients.…
View article: OS04.6.A MULTICENTER RANDOMIZED PHASE II STUDY OF R-MPV-A CHEMOIMMUNOTHERAPY WITH OR WITHOUT LOW-DOSE WHOLE-BRAIN RADIOTHERAPY FOR NEWLY DIAGNOSED PRIMARY CNS LYMPHOMA: NRG/ RTOG 1114
OS04.6.A MULTICENTER RANDOMIZED PHASE II STUDY OF R-MPV-A CHEMOIMMUNOTHERAPY WITH OR WITHOUT LOW-DOSE WHOLE-BRAIN RADIOTHERAPY FOR NEWLY DIAGNOSED PRIMARY CNS LYMPHOMA: NRG/ RTOG 1114 Open
BACKGROUND Methotrexate-based chemoradiotherapy is effective in primary central nervous system lymphoma (PCNSL), but carries a risk of severe neurotoxicity. In a single-arm study, a chemotherapy regimen with methotrexate, procarbazine, vin…
View article: Initial three‐ and half‐year machine performance assessment of a superficial radiation therapy unit
Initial three‐ and half‐year machine performance assessment of a superficial radiation therapy unit Open
Purpose This work reports on results of periodic machine quality assurance (QA) tests for our superficial radiation therapy (SRT) unit (SRT‐100 Vision) performed for the first three‐ and half‐ year. Methods Results of machine warm‐up, dosi…
View article: Assessment of Students' Inclination Towards Their Career After Final Year Exams- A Study Among the Graduate and Post Graduate Students in Jharkhand
Assessment of Students' Inclination Towards Their Career After Final Year Exams- A Study Among the Graduate and Post Graduate Students in Jharkhand Open
‘Career’ is one of the most buzzing words that not only thrives in the heart of the students, but also echoes in the minds of their parents who critically exert their best for the future career of their wards: be it to establish their care…
View article: Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions Open
Glioblastoma is the most common type of malignant primary brain tumor and a major cause of morbidity and mortality. In 2021, the World Health Organization updated the classification of Central Nervous System (CNS) tumors to restrict gliobl…
View article: Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003
Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003 Open
PURPOSE Hippocampal avoidance (HA) during therapeutic whole-brain radiotherapy reduces the risk of neurocognitive function (NCF) toxicity in patients with brain metastasis. This trial hypothesized that HA during prophylactic cranial irradi…
View article: Dual Immune Check Point Blockade in <i>MGMT</i> -Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial
Dual Immune Check Point Blockade in <i>MGMT</i> -Unmethylated Newly Diagnosed Glioblastoma: NRG Oncology BN007, a Randomized Phase II/III Clinical Trial Open
PURPOSE New therapies for glioblastoma are needed, especially MGMT -unmethylated (u MGMT ) disease. NRG Oncology BN002 (phase I) demonstrated safety and suggested efficacy of ipilimumab (ipi) with nivolumab (nivo) in newly diagnosed gliobl…
View article: CTLT-04 SAFETY AND PRELIMINARY EVIDENCE OF A THERAPEUTIC EFFECT OF AZELIRAGON COMBINED WITH STEREOTACTIC RADIATION THERAPY IN PATIENTS WITH BRAIN METASTASES: PHASE 1 STUDY RESULTS
CTLT-04 SAFETY AND PRELIMINARY EVIDENCE OF A THERAPEUTIC EFFECT OF AZELIRAGON COMBINED WITH STEREOTACTIC RADIATION THERAPY IN PATIENTS WITH BRAIN METASTASES: PHASE 1 STUDY RESULTS Open
Azeliragon is an oral, brain-penetrating small molecule inhibitor of the receptor for advanced glycation end-products (RAGE), reducing neuroinflammation by inhibiting peritumoral edema/vascular leakage and overcoming radiation resistance. …
View article: Effect of Cycle Ergometery on Functional Capacity and Pulmonary Function in Phase – I Cardiac Rehabilitation
Effect of Cycle Ergometery on Functional Capacity and Pulmonary Function in Phase – I Cardiac Rehabilitation Open
Background: Pulmonary complications are most common after the coronary artery bypass grafting. The vital role of Cardiac Rehabilitation is to prevent complication, improve functional capacity & enhance QoL of patients. The core component o…
View article: Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas
Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas Open
This Policy Review provides recommendations for the use of PET imaging in patients with gliomas and represents a joint effort of the Response Assessment in Neuro-Oncology (RANO) working group for PET and the European Association for Neuro-…
View article: Comprehensive Review of Network Intrusion Detection and Prevention Systems
Comprehensive Review of Network Intrusion Detection and Prevention Systems Open
— The global network infrastructure remains vulnerable and is susceptible to attacks from various sources. These attacks can take the form of denial-of-service (DoS) or other malicious threats. To safeguard such networks, Intrusion Detecti…
View article: Mini-Open Partial Fasciotomy for Dupuytren Contracture: Time to Reintervention
Mini-Open Partial Fasciotomy for Dupuytren Contracture: Time to Reintervention Open
Background In younger patients with Dupuytren contracture, recurrence is common over time. Mini-open fasciotomy is a surgical approach that maintains virgin tissue at the palmar digital crease. This study’s primary aim is to determine time…
View article: Pulsed reduced dose rate radiotherapy: a narrative review
Pulsed reduced dose rate radiotherapy: a narrative review Open
PRDR radiotherapy shows promising efficacy and safety across various malignancies, especially in the re-irradiation setting. It is particularly effective for CNS tumors with manageable toxicity and shows potential in recurrent breast, head…
View article: The Global Bioequivalence Harmonisation Initiative (GBHI): Report of the sixth international EUFEPS/PQRI conference
The Global Bioequivalence Harmonisation Initiative (GBHI): Report of the sixth international EUFEPS/PQRI conference Open
At the 6th International Conference of the Global Bioequivalence Harmonisation Initiative (GBHI), co-organised by the European Federation of Pharmaceutical Sciences (EUFEPS) and the Product Quality Research Institute (PQRI), critical bioeq…
View article: Proton Craniospinal Irradiation for Patients with Solid Tumor Leptomeningeal Disease: Real-World Feasibility, Toxicity, and Outcome Analysis
Proton Craniospinal Irradiation for Patients with Solid Tumor Leptomeningeal Disease: Real-World Feasibility, Toxicity, and Outcome Analysis Open
Leptomeningeal disease (LMD) is a devastating clinical scenario in patients with metastatic cancer [...]
View article: ASSESSING THE PSYCHOLOGICAL MINDSET OF WOMEN DURING AND POST CAREER BREAK: CHALLENGES AND COPING MECHANISM
ASSESSING THE PSYCHOLOGICAL MINDSET OF WOMEN DURING AND POST CAREER BREAK: CHALLENGES AND COPING MECHANISM Open
Career breaks, whether due to caregiving, personal health, or other life circumstances, can have profound psychological effects on women re-entering the workforce. This paper explores the emotional and mental health challenges women face a…