Explanipedia

Supplementary Tables S1-S8 from Pan-Cancer Analysis of Oncogenic MET Fusions Reveals Distinct Pathogenomic Subsets with Differential Sensitivity to MET-Targeted Therapy Open

Christopher A. Febres‐Aldana, Morana Vojnic, Igor Odintsov, Tom Zhang, Ryan Cheng , et al. · 2025

Table S1. Complete clinical, pathologic, and molecular annotations of oncogenic MET fusions Table S2. Summary of reports describing the use of MET-TKI to treat MET fusion-positive malignancies Table S3. Summary of antibodies used for Weste…

Data from Pan-Cancer Analysis of Oncogenic MET Fusions Reveals Distinct Pathogenomic Subsets with Differential Sensitivity to MET-Targeted Therapy Open

Christopher A. Febres‐Aldana, Morana Vojnic, Igor Odintsov, Tom Zhang, Ryan Cheng , et al. · 2025

MET fusions (MET-F) are oncogenic drivers that remain poorly characterized. Analysis of 56 MET-F–positive tumors from an institutional cohort of 91,119 patients (79,864 DNA sequencing plus 11,255 RNA sequencing) uncovered two forms …

Supplementary Figures S1-S10 from Pan-Cancer Analysis of Oncogenic MET Fusions Reveals Distinct Pathogenomic Subsets with Differential Sensitivity to MET-Targeted Therapy Open

Christopher A. Febres‐Aldana, Morana Vojnic, Igor Odintsov, Tom Zhang, Ryan Cheng , et al. · 2025

Supplementary Figure S1. Features of intergenic MET structural variants (SV) classified as SV of unknown significance Supplementary Figure S2. Clinicopathologic features and mutation signature analysis Supplementary Figure S3. Analysis of …

A high number of tumor deposits (≥ 4) is an isolated predictor of local recurrence and distant metastasis in non-metastatic colorectal cancer: a single center study Open

Ahmed Bendari, Elif Yılmazel Uçar, Alaa Bendari, Hamed Hammoud, FNU Kiran , et al. · 2025

Introduction Local recurrence and distant metastasis after curative surgery and chemotherapy for colorectal cancer (CRC) is a serious complication and is considered a failure of the therapeutic strategy. The aim of this study is to identif…

“Comprehensive Analysis of Factors Influencing Recurrence and Survival in Glioblastoma: Implications for Treatment Strategies”: A Single Center Study Open

Ahmed Bendari, Sunder Sham, Hamed Hammoud, Oana Vele, Brett Baskovich , et al. · 2024

Glioblastoma is a highly aggressive malignancy affecting the brain and central nervous system. It is the most common malignant primary brain tumor, yet its prognosis remains poor. Median survival typically ranges from around 13 months with…

7564 Adrenal Pheochromocytoma In A Clinically Inapparent Adrenal Mass Open

Luis Medina, Sheryl Thant Yu Htoo, A Sánchez Ruíz, Manju Harshan, Agustin Busta · 2024

Disclosure: L. Medina Mora: None. S. Htoo: None. A. Sanchez Ruiz: None. M. Harshan: None. A. Busta: None. Introduction: Pheochromocytomas (PCC) are rare tumors that arise from the adrenal medulla, with an estimated annual incidence of 0.8 …

6530 A Case of Lymphocytic Hypophysitis Followed by Acromegaly Open

Luis Medina, Sheryl Thant Yu Htoo, A Sánchez Ruíz, Manju Harshan, Ming Liu · 2024

Disclosure: L. Medina Mora: None. S. Htoo: None. A. Sanchez Ruiz: None. M. Harshan: None. M. Liu: None. Introduction: Acromegaly, a disorder with an estimated incidence of 0.28-0.4 cases per 100,000 individuals, is characterized by overpro…

Unraveling the Mystery of Rathke's Cleft Cyst Presenting with Hyponatremia: A Case Report with a Comprehensive Review of Literature Open

S. Huda, Souvik Singha, Ali Haidous, Phillip Bukberg, Bidyut K. Pramanik , et al. · 2024

Rathke's cleft cyst (RCC) is a benign cystic lesion that is commonly discovered incidentally and remains asymptomatic in most cases. However, its association with the syndrome of inappropriate antidiuretic hormone (SIADH) secretion leading…

Malignant Pericardial Effusion from Cervical Squamous Cell Carcinoma: A Case Study Open

Sunder Sham, Saroja Devi Geetha, Alae Kawam, Ahmed Bendari, Reham Al‐Refai , et al. · 2024

BACKGROUND Cervical cancer ranks fourth globally among women's cancers. Squamous cell carcinoma constitutes 70% of cervical cancer cases, often metastasizing to lungs and paraaortic nodes. Uncommon sites include the brain, skin, spleen, an…

Correction to: Results from a first-in-human phase I safety trial to evaluate the use of a vascularized pericranial/temporoparietal fascial flap to line the resection cavity following resection of newly diagnosed glioblastoma Open

Omer Doron, Tamika Wong, Faina Ablyazova, Souvik Singha, Julianna Cavallaro , et al. · 2024

Results from a first-in-human phase I safety trial to evaluate the use of a vascularized pericranial/temporoparietal fascial flap to line the resection cavity following resection of newly diagnosed glioblastoma Open

Omer Doron, Tamika Wong, Faina Ablyazova, Souvik Singha, Julianna Cavallaro , et al. · 2024

Purpose The efficacy of systemic therapies for glioblastoma (GBM) remains limited due to the constraints of systemic toxicity and blood–brain barrier (BBB) permeability. Temporoparietal fascial flaps (TPFFs) and vascularized peri cranial f…

Papillary Thyroid Carcinoma With Lymphoepithelial Features and Lacking Association With Epstein-Barr Virus (EBV): A Rare Case Open

Ahmed Bendari, Saroja Devi Geetha, Reham Al‐Refai, Xuelin Zhong, Sunder Sham , et al. · 2024

Primary adenoid cystic carcinoma in the lung: Reporting two cases and mini-literature review Open

Ahmed Bendari, Xuelin Zhong, Sunder Sham, Reham Al‐Refai, Aisha Abdelhafez , et al. · 2023

Primary adenoid cystic carcinoma (ACC) accounts for less than 0.2 % of all primary lung malignancies. Here we present two cases of lung ACC (ACCL), first is a 65-year-old female who was diagnosed with ACCL and surgically treated at another…

Low-grade B-cell lymphomas in the spinal epidural space: A case series and review of the literature Open

Sandra Leskinen, Hamza Khilji, Faina Ablyazova, Avraham Zlochower, Manju Harshan , et al. · 2023

Lymphoma rarely arises within the central nervous system and occurs most commonly in association with disseminated systemic disease. Primary epidural lymphomas of the spine are infrequently encountered and are usually high-grade, diffuse l…

Application of WHO CNS Fifth Edition Criteria for Glioblastoma Multiforme Diagnosis: A single center study Open

Ahmed Bendari, Sunder Sham, H. Hammoud, Reham Al‐Refai, Amal A.A. Abd-El-Hafez , et al. · 2023

Introduction/Objective The fifth edition of the WHO classification of the tumors of the central nervous system (WHO CNS 5) published in 2021 introduced major changes that incorporate molecular diagnostics in CNS tumor classification along …

Prioritizing Radiation and Targeted Systemic Therapy in Patients with Resected Brain Metastases from Lung Cancer Primaries with Targetable Mutations: A Report from a Multi-Site Single Institution Open

Y.R. Wuu, Benedetta Gui, Mostafa Kokabee, Jacqueline Stone, Jessie Karten , et al. · 2023

A Rare Cancer in an Elderly Man with Cervical Radiculopathy: A case report Open

Sunder Sham, Hossein Hosseini, Doaa Morra, Ahmed Bendari, Reham Al‐Refai , et al. · 2023

Background: Chordomas are low-grade, locally invasive, frequently recurring, malignant bone tumor with poor prognosis. Cervical chordoma in adults is rare and often missed when patients present with cervical radiculopathy. They can mimic o…

A Rare Cancer in an Elderly Man with Cervical Radiculopathy: A Case Report Open

Sunder Sham, Hossein Hosseini, Beatriz Caraballo Bordon, Doaa Morrar, Ahmed Bendari , et al. · 2023

Chordomas are low-grade, locally invasive, frequently recurring, malignant bone tumor with poor prognosis. Cervical chordoma in adults is rare and often missed when patients present with cervical radiculopathy. They can mimic other maligna…

Intracranial Extramedullary Hematopoiesis: a Rare Entity Open

Doaa Morrar, Sunder Sham, Reham Al‐Refai, Manju Harshan · 2022

Introduction/Objective Extramedullary hematopoiesis (EMH) is characterized by ectopic proliferation and differentiation of hematopoietic precursor cells outside the bone marrow. In postnatal life, EMH occurs due to hematopoietic disorders,…

Calcifying Pseudoneoplasm of the Neuraxis in the Posterior Fossa: A Case Report and Literature Review Open

Colin A Dallimore, Mica Quelle, Likowsky L Désir, Sham Sunder, Manju Harshan , et al. · 2022

Calcifying pseudoneoplasm of the neuraxis are rare fibro-osseous lesions that can occur throughout the central nervous system. This paper reports one case of this lesion within the posterior fossa and contains a literature review of all ca…

A 33-Year-Old Man With Chest Pain Open

Matthew Ballenberger, Morana Vojnic, Madhuri Indaram, Stephen Machnicki, Manju Harshan , et al. · 2022

Sarcomatous Change of Cerebellopontine Angle Ependymoma Following Radiosurgery: A Case Report Open

Nicholas B. Dadario, Rachel Pruitt, Justin W. Silverstein, Avraham Zlochower, Sewit Teckie , et al. · 2022

Sarcomatous change in ependymal tumors is rare and has been poorly described. We report on a cerebellopontine angle lesion that demonstrated rapid progression two years after radiosurgery in a 73-year-old female patient. Histopathological …

Breast involvement in mixed connective tissue disease Open

Ross Varma, Sándor Miklós Szilágyi, Manju Harshan · 2019

To date, mammographic involvement in mixed connective tissue disease has not been described in the literature to the authors' knowledge. In addition, only 2 case reports have described panniculitis in mixed connective tissue disease. We pr…

Learning Ultrasound Guided Fine-Needle Aspiration of Thyroid and Head and Neck Lesions: A Practical Teaching Model for Pathology Residents Open

Roshan Raza, Adnan Mubasher, Manju Harshan · 2018

Mount Sinai Downtown has a unique cytopathologist-run ultrasound-guided fine-needle aspiration (FNA) clinic where residents complete a 4-week rotation and perform ultrasound-guided FNAs under direct supervision, in addition to palpable FNA…

Using Blue Phantom for Practicing Ultrasound Guided Fine-Needle Aspiration (FNA) Techniques Open

Roshan Raza, Manju Harshan · 2018

A Rare Case of Isolated Pancreatic Tuberculosis Open

Daniel J. Waintraub, Lionel DʼSouza, Emilio Madrigal, Manju Harshan, Gil Ascunce · 2016

Pancreatic tuberculosis (TB) is a rare but important entity to consider when evaluating a pancreatic mass, especially in patients from endemic areas. Its clinical and radiologic features may mimic those of a pancreatic neoplasm, making it …

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