Manju Mohanty
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View article: Comparison of FDOPA and FDG PET in Parkinson’s Disease Patients with and without Freezing of Gait
Comparison of FDOPA and FDG PET in Parkinson’s Disease Patients with and without Freezing of Gait Open
Purpose of the Study: This study compared striatal dopamine metabolism and cerebral glucose metabolism in Parkinson’s disease patients with and without freezing of gait (FOG) using Fluorodeoxyglucose positron emission tomography (FDG-PET) …
View article: Comparison of propofol and desflurane for postoperative neurocognitive function in patients with aneurysmal subarachnoid hemorrhage: A prospective randomized trial
Comparison of propofol and desflurane for postoperative neurocognitive function in patients with aneurysmal subarachnoid hemorrhage: A prospective randomized trial Open
Background: Following aneurysmal subarachnoid hemorrhage, 40–50% of survivors experience cognitive dysfunction, which affects their quality of life. Anesthetic agents play a pivotal role in aneurysm surgeries. However, substantial evidence…
View article: 6 A Study to Assess the Impact of Injury Severity on Disease Specific Quality of Life After Traumatic Brain Injury (TBI)
6 A Study to Assess the Impact of Injury Severity on Disease Specific Quality of Life After Traumatic Brain Injury (TBI) Open
Objective: To assess the impact of injury severity on disease specific quality of life after Traumatic Brain Injury Participants and Methods: The study was carried out in Department of Neurosurgery, Post Graduate Institute of Medical Educa…
View article: 30 A Study to Assess Functional and Psychological Outcome After 6 Months of Moderate and Severe Traumatic Brain Injury (TBI)
30 A Study to Assess Functional and Psychological Outcome After 6 Months of Moderate and Severe Traumatic Brain Injury (TBI) Open
Objective: Assessment of clinical, functional and psychological outcome after 6 months of moderate and severe TBI Participants and Methods: Sixty consecutive participants aged 18 and above with moderate to severe TBI (GCS score of 3-12 at …
View article: Outcomes in pituitary adenoma causing acromegaly following endoscopic endonasal transsphenoidal surgery
Outcomes in pituitary adenoma causing acromegaly following endoscopic endonasal transsphenoidal surgery Open
Objectives: The objectives of the study were to study the analysis of outcomes after endoscopic endonasal transsphenoidal surgery (EETSS) in acromegaly in terms of surgical complications, clinical improvement, endocrinological remission, a…
View article: Outcomes in Pituitary Adenoma Causing Acromegaly Following Endoscopic Endonasal Transsphenoidal Surgery
Outcomes in Pituitary Adenoma Causing Acromegaly Following Endoscopic Endonasal Transsphenoidal Surgery Open
Objectives The objective of this study was the analysis of outcomes after endoscopic endonasal transsphenoidal surgery (EETSS) in acromegaly in terms of surgical complications, clinical improvement, endocrinological remission, achievement …
View article: Yoga as a Preventive Intervention for Cardiovascular Diseases and Associated Comorbidities: Open-Label Single Arm Study
Yoga as a Preventive Intervention for Cardiovascular Diseases and Associated Comorbidities: Open-Label Single Arm Study Open
Aim Common Yoga Protocol (CYP) is a standardized yoga protocol authored by experts from all over the world under the aegis of the Ministry of AYUSH, Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa Rigpa and Homeopathy (AYUSH). The pote…
View article: Supplementary Material for: Neuro-Psychological differences between the unilateral and bilateral tinnitus participants with normal hearing.
Supplementary Material for: Neuro-Psychological differences between the unilateral and bilateral tinnitus participants with normal hearing. Open
Objective: This paper attempts to describe the neuropsychological differences between subgroups of tinnitus with normal hearing. Materials and Methods: The study compared 150 normal-hearing participants with and without tinnitus in the 18-…
View article: Evaluation of Plasma Amyloid Peptides Aβ1-40 and Aβ1-42 as Diagnostic Biomarker of Alzheimer's Disease, its Association with Different Grades of Clinical Severity and 18F-Fluorodeoxyglucose Positron Emission Tomography Z score in the Indian Population
Evaluation of Plasma Amyloid Peptides Aβ1-40 and Aβ1-42 as Diagnostic Biomarker of Alzheimer's Disease, its Association with Different Grades of Clinical Severity and 18F-Fluorodeoxyglucose Positron Emission Tomography Z score in the Indian Population Open
Background: We estimated plasma amyloid-peptides levels (Aβ 1-42 and Aβ 1-40 ) as diagnostic biomarker of Alzheimer's disease (AD) and evaluated its association with clinical severity and 18F-fluorodeoxyglucose positron emission tomography…
View article: Head injury care in a low- and middle-income country tertiary trauma center: epidemiology, systemic lacunae, and possible leads
Head injury care in a low- and middle-income country tertiary trauma center: epidemiology, systemic lacunae, and possible leads Open
The study represents the much-needed, large-volume, epidemiological profile of HI from an LMIC, highlighting the suboptimal utilization of peripheral healthcare systems. Strengthening and integrating these facilities with the tertiary cent…
View article: Working Memory Alterations Plays an Essential Role in Developing Global Neuropsychological Impairment in Duchenne Muscular Dystrophy
Working Memory Alterations Plays an Essential Role in Developing Global Neuropsychological Impairment in Duchenne Muscular Dystrophy Open
Background Neuropsychological profile of Indian Duchenne muscular dystrophy (DMD) subjects remains unidentified and needs to be evaluated. Methods A total of 69 DMD and 66 controls were subjected to detailed intelligence and neuropsycholog…
View article: COVID-19: changing patterns among neurosurgical patients from North India, efficacy of repeat testing, and inpatient prevalence
COVID-19: changing patterns among neurosurgical patients from North India, efficacy of repeat testing, and inpatient prevalence Open
OBJECTIVE COVID-19 has affected surgical practice globally. Treating neurosurgical patients with the restrictions imposed by the pandemic is challenging in institutions with shared patient areas. The present study was performed to assess t…
View article: Computational cognitive modeling and validation of Dp140 induced alteration of working memory in Duchenne Muscular Dystrophy
Computational cognitive modeling and validation of Dp140 induced alteration of working memory in Duchenne Muscular Dystrophy Open
View article: Comparison of postoperative cognitive dysfunction with the use of propofol versus desflurane in patients undergoing surgery for clipping of aneurysm after subarachnoid hemorrhage
Comparison of postoperative cognitive dysfunction with the use of propofol versus desflurane in patients undergoing surgery for clipping of aneurysm after subarachnoid hemorrhage Open
Background: Cerebral aneurysm rupture is a distinct entity among various causes of cerebrovascular accident. Despite the current concept of early surgical clipping to prevent consequences of ruptured aneurysm in good grade subarachnoid hem…
View article: Assessment of behavioral symptoms of post-operative patients with intracranial tumor and distress among their caregivers
Assessment of behavioral symptoms of post-operative patients with intracranial tumor and distress among their caregivers Open
View article: Efficacy of bacopa monnieri (Brahmi) and Donepezil in Alzheimer's Disease and mild cognitive impairment: A randomized double-blind parallel Phase 2b study
Efficacy of bacopa monnieri (Brahmi) and Donepezil in Alzheimer's Disease and mild cognitive impairment: A randomized double-blind parallel Phase 2b study Open
This phase-2 RCT on the efficacy of brahmi vs. donepezil showed no significant difference between them after 1 year of treatment. Larger phase-3 trials, preferably multicentric, are required to find the superiority of brahmi over donepezil.
View article: Does Type-D Personality Impact Risk of Adverse Behavioural Changes in Patients with Intracranial Tumours?
Does Type-D Personality Impact Risk of Adverse Behavioural Changes in Patients with Intracranial Tumours? Open
In this study, conducted to assess the in uence of the type-D personality of patients with intracranial tumours on their behavioural changes, a prospective design was undertaken. Patients were enrolled before surgery or any de nitive treat…
View article: Comparison of postoperative delirium in patients anesthetized with isoflurane versus desflurane during spinal surgery: A prospective randomized controlled trial
Comparison of postoperative delirium in patients anesthetized with isoflurane versus desflurane during spinal surgery: A prospective randomized controlled trial Open
Background: Following spine surgery, different types of inhalational anesthetic agents can result in postoperative delirium (POD) that can increase perioperative/postoperative morbidity. Here, we compared the incidence of POD in adults und…
View article: Repurposing Pathogenic Variants of <i>DMD</i> Gene and its Isoforms for DMD Exon Skipping Intervention
Repurposing Pathogenic Variants of <i>DMD</i> Gene and its Isoforms for DMD Exon Skipping Intervention Open
Background: Duchenne Muscular Dystrophy (DMD) is a progressive, fatal neuromuscular disorder caused by mutations in the DMD gene. Emerging antisense oligomer based exon skipping therapy provides hope for the restoration of the reading fram…
View article: PCN427 ASSESSING THE PERFORMANCE OF PARAMETRIC SURVIVAL MODELS USING REAL WORLD EVIDENCE IN CML, LUNG AND PROSTATE CANCER
PCN427 ASSESSING THE PERFORMANCE OF PARAMETRIC SURVIVAL MODELS USING REAL WORLD EVIDENCE IN CML, LUNG AND PROSTATE CANCER Open
View article: The Role of <i>Dystrophin</i> Gene Mutations in Neuropsychological Domains of DMD Boys: A Longitudinal Study
The Role of <i>Dystrophin</i> Gene Mutations in Neuropsychological Domains of DMD Boys: A Longitudinal Study Open
Background: Duchenne Muscular Dystrophy (DMD) is a fatal muscular dystrophy of pediatric population coupled with other secondary comorbidities including mental retardation and neuropsychological impairments. Mutation location in the dystro…
View article: Assessment of behavioral symptoms of post-operative patients with intracranial tumor and distress among their caregiver
Assessment of behavioral symptoms of post-operative patients with intracranial tumor and distress among their caregiver Open
View article: Functional MRI in epilepsy – Comparison of Lateralization index and language scoring
Functional MRI in epilepsy – Comparison of Lateralization index and language scoring Open
Aims: To evaluate the role of functional magnetic resonance imaging (fMRI) in epilepsy management and to ascertain whether laterality index (LI) derived from fMRI data, using routinely utilized paradigms, can serve as an adjunct to/or repl…
View article: Effect of Extent of Hippocampal and Amygdala Resection on Seizure Outcome in Patients with Refractory Epilepsy Secondary to Medial Temporal Sclerosis
Effect of Extent of Hippocampal and Amygdala Resection on Seizure Outcome in Patients with Refractory Epilepsy Secondary to Medial Temporal Sclerosis Open
Introduction:Anterior temporal lobectomy with amygdalohippocampectomy is the most common surgical procedure for refractory epilepsy secondary to mesial temporal sclerosis.There is no consensus on whether the degree of hippocampal or amygda…
View article: Effect of Anesthetic Agents on Cognitive Function and Peripheral Inflammatory Biomarkers in Young Patients Undergoing Surgery for Spine Disorders
Effect of Anesthetic Agents on Cognitive Function and Peripheral Inflammatory Biomarkers in Young Patients Undergoing Surgery for Spine Disorders Open
Methodology/
View article: Comparison of pharmacological neuroprotection provided by propofol versus desflurane for long term postoperative cognitive dysfunction in patients undergoing surgery for aneurysmal subarachnoid hemorrhage
Comparison of pharmacological neuroprotection provided by propofol versus desflurane for long term postoperative cognitive dysfunction in patients undergoing surgery for aneurysmal subarachnoid hemorrhage Open
Introduction: Aneurysmal subarachnoid hemorrhage (aSAH) is an acute life threatening condition with 30-40% mortality rate. Amongst the survivors, 40-50% suffers disability due to cognitive decline affecting quality of life on long term bas…
View article: Pre-operative anxiety in intracranial neoplasm patients undergoing surgery and assessment of its predictors
Pre-operative anxiety in intracranial neoplasm patients undergoing surgery and assessment of its predictors Open
Introduction: Pre-operative anxiety in intracranial neoplasm is very important aspect of peri-operative care. The primary aim of the present study is to find out prospectively levels of anxiety in these patients and assessment of factors a…
View article: Clinical, molecular imaging and biomarker concordance in the diagnosis of Alzheimer’s disease and vascular dementia
Clinical, molecular imaging and biomarker concordance in the diagnosis of Alzheimer’s disease and vascular dementia Open
View article: Prevalence and Trends in the Neuropsychological Burden of Patients having Intracranial Tumors with Respect to Neurosurgical Intervention
Prevalence and Trends in the Neuropsychological Burden of Patients having Intracranial Tumors with Respect to Neurosurgical Intervention Open
There is substantial neuropsychological burden among patients with intracranial tumors. The severity score improved immediately after surgery, while the symptom score improved gradually. The variable spectrum of improvement in neuropsychol…
View article: Role of Plasma Clusterin in Alzheimer’s Disease—A Pilot Study in a Tertiary Hospital in Northern India
Role of Plasma Clusterin in Alzheimer’s Disease—A Pilot Study in a Tertiary Hospital in Northern India Open
Our pilot study shows that plasma clusterin is lower in Alzheimer's disease with respect to control population. Plasma clusterin levels and severity of Alzheimer's disease had no significant correlation. There was no difference in plasma c…