Manisha Saini
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View article: Phenological aspects and Ecological significance of Native Plants of Aravalli range adjoining district Gurugram, Haryana
Phenological aspects and Ecological significance of Native Plants of Aravalli range adjoining district Gurugram, Haryana Open
The Aravalli range is the oldest mountain systems in India and supports a semi-arid, dry deciduous ecosystem that is vital for maintaining ecological stability in northwestern India. Rapid urbanization and ecological degradation have inten…
View article: Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals
Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals Open
Dengue viruses (DENVs) infect approximately 400 million people each year, and currently, there are no effective therapeutics available. To explore potential starting points for antiviral drug development, we conducted a large-scale crystal…
View article: Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals
Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals Open
Dengue viruses (DENV) infect approximately 400 million people each year, and there are currently no effective therapeutics available. To explore potential starting points for antiviral drug development, we conducted a large-scale crystallo…
View article: A Comprehensive Review on Application of Conventional and Mutation Approaches in Genetic Improvement of Ornamental Crops
A Comprehensive Review on Application of Conventional and Mutation Approaches in Genetic Improvement of Ornamental Crops Open
Effective mutagenic treatment techniques for different species are of tremendous interest due to the exciting potential of mutation breeding in ornamental plants. The present article addresses the mutagenesis treatments of numerous ornamen…
View article: Utility of DNA Technology in Indian Criminal Legal Justice System
Utility of DNA Technology in Indian Criminal Legal Justice System Open
The admissibility of the DNA evidence before the court always depends on its accurate and proper collection, preservation and documentation which can satisfy the court that the evidence which has been put in front it is reliable. There is …
View article: Time-Restricted Eating Regimen Differentially Affects Circulatory miRNA Expression in Older Overweight Adults
Time-Restricted Eating Regimen Differentially Affects Circulatory miRNA Expression in Older Overweight Adults Open
Time-restricted eating (TRE), a popular form of intermittent fasting, has been demonstrated to provide multiple health benefits, including an extension of healthy lifespan in preclinical models. While the specific mechanisms remain elusive…
View article: Understanding Health Related Quality of Life in Hypertensive Patients: Interrogating Effect of Psychological and Environmental Factors
Understanding Health Related Quality of Life in Hypertensive Patients: Interrogating Effect of Psychological and Environmental Factors Open
Background: Health-related quality of life has become an important aspect in the field of healthcare as an important outcome measure for chronic diseases like hypertension. Improvement in HRQoL have become a focal point in…
View article: Study of Solutions of Certain Kind of Non-Linear Differential Equations
Study of Solutions of Certain Kind of Non-Linear Differential Equations Open
In this paper we study about the existence of solutions of certain kind of non-linear differential and differential-difference equations. We give partial answer to a problem which was asked by chen et al. in [13].
View article: Repurposing the Pathogen Box compounds for identification of potent anti-malarials against blood stages of Plasmodium falciparum with PfUCHL3 inhibitory activity
Repurposing the Pathogen Box compounds for identification of potent anti-malarials against blood stages of Plasmodium falciparum with PfUCHL3 inhibitory activity Open
View article: Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review
Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review Open
Over the last few decades, substantial progress has been made towards the understanding of cardiovascular diseases. In-depth mechanistic insights have also provided opportunities to explore novel therapeutic targets and to discover new tre…
View article: SUPRAMOLECULAR DRUG CARRIERS IN CANCER THERAPEUTICS
SUPRAMOLECULAR DRUG CARRIERS IN CANCER THERAPEUTICS Open
Cancer has a significant effect on society worldwide. Statistics on cancer explain what happens in a large set of people and give a real picture of the burden on society. A number of cancer treatments are accessible nowadays and enormous n…
View article: Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis
Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis Open
The ARL15 gene (ADP ribosylation factor like protein 15) encodes for an uncharacterized small GTP-binding protein. Its exact role in human physiology remains unknown, but a number of genetic association studies have recognised different va…
View article: Suramin, Penciclovir, and Anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2
Suramin, Penciclovir, and Anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2 Open
COVID-19, for which no confirmed therapeutic agents are available, has claimed over 48,14,000 lives globally. A feasible and quicker method to resolve this problem may be ‘drug repositioning’. We investigated selected FDA and WHO-EML appro…
View article: Screening of Antihypertensive Effects of GK4: From Computers to Rats
Screening of Antihypertensive Effects of GK4: From Computers to Rats Open
Background: Despite of a large number of commercially available drugs, hypertension adversely affect humans globally at an alarming rate and still poses a global disease burden. Literature suggests that hypertension can be regulated by inh…
View article: Growth of Solutions of Second Order Linear Differential Equations
Growth of Solutions of Second Order Linear Differential Equations Open
In this paper, we will prove that all non-trivial solutions of $f''+A(z)f'+B(z)f=0$ are of infinite order, where we have some restrictions on entire functions $A(z)$ and $B(z)$.
View article: Cardiovascular manifestation in hospitalised cases of swine flu
Cardiovascular manifestation in hospitalised cases of swine flu Open
View article: Non-Existence of Finite Order Solution of Non-homogeneous Second Order\n Linear Differential Equations
Non-Existence of Finite Order Solution of Non-homogeneous Second Order\n Linear Differential Equations Open
In this paper, we have considered second order non-homogeneous linear\ndifferential equations having entire coefficients. We have established\nconditions ensuring non-existence of finite order solution of such type of\ndifferential equatio…
View article: Order and Hyper-order of Solutions of Second Order Linear Differential\n Equations
Order and Hyper-order of Solutions of Second Order Linear Differential\n Equations Open
We have discussed the problem of finding the condition on coefficients of\n$f''+A(z)f'+B(z)f=0, \\quad B(z)(\\not \\equiv 0)$ so that all non-trivial\nsolutions are of infinite order. The hyper-order of these non-trivial solutions\nof infi…
View article: Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine
Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine Open
View article: Mucoadhesive drug delivery system: an overview
Mucoadhesive drug delivery system: an overview Open
The major objective of any dosage form is to deliver an optimum therapeutic amount of active agent to the proper site in the body to attain constant & maintenance of the desired drug concentration. Mucoadhesive drug delivery systems are ef…
View article: Elevated frequencies of micronuclei and other nuclear anomalies in alcoholic subjects
Elevated frequencies of micronuclei and other nuclear anomalies in alcoholic subjects Open
The present study was aimed to investigate the frequency of micronuclei and other nuclear anomalies in alcoholic subjects. The present study included 100 subjects out of which 54 were alcoholics (23 smokers and 31 non smokers) and 46 subj…