Manjun Li
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View article: Comparative evaluation of hepatic-targeted knock-in strategies using viral and nonviral vector combinations in mouse inherited disease models
Comparative evaluation of hepatic-targeted knock-in strategies using viral and nonviral vector combinations in mouse inherited disease models Open
CRISPR-Cas9-mediated gene knock-in has emerged as a promising strategy for early-onset genetic disease intervention. However, the therapeutic efficacy and editing outcomes of different knock-in strategies remain incompletely understood. He…
View article: Shear Behavior of Curved Concrete Structures Repaired with Sustainability-Oriented Trenchless Polymer Grouting
Shear Behavior of Curved Concrete Structures Repaired with Sustainability-Oriented Trenchless Polymer Grouting Open
Urban underground infrastructure is increasingly challenged by material aging, environmental degradation, and structural deterioration. In response, trenchless polymer grouting technologies employing sustainability-oriented two-component f…
View article: <i>iMeta</i> Conference 2025: Creating high‐impact international journals
<i>iMeta</i> Conference 2025: Creating high‐impact international journals Open
View article: Large Language Models as End-to-end Combinatorial Optimization Solvers
Large Language Models as End-to-end Combinatorial Optimization Solvers Open
Combinatorial optimization (CO) problems, central to decision-making scenarios like logistics and manufacturing, are traditionally solved using problem-specific algorithms requiring significant domain expertise. While large language models…
View article: Proteomics and cytokine array jointly reveal the role of macrophage proinflammatory shift in liver fibrosis in dairy cows with ketosis
Proteomics and cytokine array jointly reveal the role of macrophage proinflammatory shift in liver fibrosis in dairy cows with ketosis Open
View article: Case Report: Summary of multiple CAR-T expansions in anti-BCMA/GPRC5D bispecific CAR-T cell therapy for multiple myeloma
Case Report: Summary of multiple CAR-T expansions in anti-BCMA/GPRC5D bispecific CAR-T cell therapy for multiple myeloma Open
Chimeric antigen receptor (CAR) -T cell therapy targeting B-cell maturation antigen (BCMA) has demonstrated significant efficacy and is considered an ideal target for the treatment of relapsed or refractory multiple myeloma (R/R MM). Howev…
View article: The characteristics of tissue microbiota in different anatomical locations and different tissue types of the colorectum in patients with colorectal cancer
The characteristics of tissue microbiota in different anatomical locations and different tissue types of the colorectum in patients with colorectal cancer Open
The gut microbiota is intricately associated with the onset and progression of colorectal cancer (CRC), leading to significant interest in developing prevention and treatment strategies that leverage gut microbiota. In this study, we colle…
View article: An orthotopic syngeneic mouse model of bortezomib‐resistant multiple myeloma
An orthotopic syngeneic mouse model of bortezomib‐resistant multiple myeloma Open
Summary While bortezomib has significant benefits in multiple myeloma (MM) therapy, the disease remains incurable due to the invariable development of bortezomib resistance. This emphasises the need for advanced models for preclinical eval…
View article: Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia
Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia Open
Inducing cell death by the sphingolipid ceramide is a potential anticancer strategy, but the underlying mechanisms remain poorly defined. In this study, triggering an accumulation of ceramide in acute myeloid leukemia (AML) cells by inhibi…
View article: An Orally Bioavailable and Highly Efficacious Inhibitor of CDK9/FLT3 for the Treatment of Acute Myeloid Leukemia
An Orally Bioavailable and Highly Efficacious Inhibitor of CDK9/FLT3 for the Treatment of Acute Myeloid Leukemia Open
Mutations in FMS-like tyrosine kinase 3 (FLT3) occur in approximately one-third of AML patients and are associated with a particularly poor prognosis. The most common mutation, FLT3-ITD, is a self-activating internal tandem duplication (IT…
View article: Statistical damage constitutive model for the two-component foaming polymer grouting material
Statistical damage constitutive model for the two-component foaming polymer grouting material Open
Two-component foaming polymer (TFPU) grouting material is increasingly used in civil engineering. Its compressive strength is key to achieving the desired enhancing effect. The constitutive model of TFPU grouting material is a theoretical …
View article: Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition
Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition Open
The introduction of the proteasome inhibitor bortezomib into treatment regimens for myeloma has led to substantial improvement in patient survival. However, whilst bortezomib elicits initial responses in many myeloma patients, this haemato…
View article: Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation
Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation Open
View article: Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation
Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation Open
View article: Vincristine upregulates PD-L1 and increases the efficacy of PD-L1 blockade therapy in diffuse large B-cell lymphoma
Vincristine upregulates PD-L1 and increases the efficacy of PD-L1 blockade therapy in diffuse large B-cell lymphoma Open
View article: Quadratus lumborum block versus transversus abdominis plane block for postoperative pain management after laparoscopic colorectal surgery
Quadratus lumborum block versus transversus abdominis plane block for postoperative pain management after laparoscopic colorectal surgery Open
Background: This study aimed to compare the quadratus lumborum block (QLB) method with transversus abdominis plane block (TAPB) for postoperative pain management in patients undergoing laparoscopic colorectal surgery. Methods: Seventy-four…
View article: Isoprenaline protects intestinal stem cells from chemotherapy‐induced damage
Isoprenaline protects intestinal stem cells from chemotherapy‐induced damage Open
Background and Purpose Damage to intestinal epithelial cells and mucosa limits the effectiveness of several anti‐cancer chemotherapeutic agents but the underlying mechanism (s) remain unknown. Little is known of how enteric nervous system …
View article: Synthesis and evaluation of 2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione derivatives as Mnk inhibitors
Synthesis and evaluation of 2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione derivatives as Mnk inhibitors Open
View article: Discovery of CDK5 Inhibitors through Structure-Guided Approach
Discovery of CDK5 Inhibitors through Structure-Guided Approach Open
Specific abrogation of cyclin-dependent kinase 5 (CDK5) activity has been validated as a viable approach for the development of anticancer agents. However, no selective CDK5 inhibitor has been reported to date. Herein, a structure-based
View article: Ceritinib Enhances the Efficacy of Substrate Chemotherapeutic Agent in Human ABCB1-Overexpressing Leukemia Cells In Vitro, In Vivo and Ex-Vivo
Ceritinib Enhances the Efficacy of Substrate Chemotherapeutic Agent in Human ABCB1-Overexpressing Leukemia Cells In Vitro, In Vivo and Ex-Vivo Open
Background/Aims: Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporters, such as ABCB1, ABCC1, and ABCG2, is a key obstacle for successful cancer chemotherapy. There is currently no FDA-approved MDR modulator that …