Suresh T. Chari
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View article: Heuriskance: a novel paradigm for systematic earlier detection of sporadic pancreatic cancer
Heuriskance: a novel paradigm for systematic earlier detection of sporadic pancreatic cancer Open
Early detection is key to improving survival and mortality from pancreatic cancer. Traditional periodic screening for cancer in an asymptomatic population is infeasible and not recommended for this low-incidence disease. We describe a nove…
View article: Designing Rigorous and Efficient Clinical Utility Studies for Early Detection Biomarkers
Designing Rigorous and Efficient Clinical Utility Studies for Early Detection Biomarkers Open
Before implementing a biomarker in routine clinical care, it must demonstrate clinical utility by leading to clinical actions that positively affect patient-relevant outcomes. Randomly controlled early detection utility trials, especially …
View article: Proteomic profiling of small extracellular vesicles derived from mouse pancreatic cancer and stellate cells: Role in pancreatic cancer
Proteomic profiling of small extracellular vesicles derived from mouse pancreatic cancer and stellate cells: Role in pancreatic cancer Open
Small extracellular vesicles (sEVs) are cell‐derived vesicles evolving as important elements involved in all stages of cancers. sEVs bear unique protein signatures that may serve as biomarkers. Pancreatic cancer (PC) records a very poor su…
View article: New-onset diabetes is a predictive risk factor for pancreatic lesions in high-risk individuals: An observational cohort study
New-onset diabetes is a predictive risk factor for pancreatic lesions in high-risk individuals: An observational cohort study Open
Background and Objectives Pancreatic cancer (PC) is the third cause of cancer-related deaths. Early detection and interception of premalignant pancreatic lesions represent a promising strategy to improve outcomes. We evaluated risk factors…
View article: Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design
Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design Open
View article: Table of Contents
Table of Contents Open
View article: Validation of the Distinct Entity “Chronic Pancreatitis Without Prior Acute Pancreatitis”: Complementary Role of Population- and Clinic-Based Studies
Validation of the Distinct Entity “Chronic Pancreatitis Without Prior Acute Pancreatitis”: Complementary Role of Population- and Clinic-Based Studies Open
View article: Long-Term Outcomes and Risk of Pancreatic Cancer in Intraductal Papillary Mucinous Neoplasms
Long-Term Outcomes and Risk of Pancreatic Cancer in Intraductal Papillary Mucinous Neoplasms Open
Importance Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cysts that can give rise to pancreatic cancer (PC). Limited population data exist on their prevalence, natural history, or risk of malignant transformation (IPMN-PC…
View article: Automated Artificial Intelligence Model Trained on a Large Data Set Can Detect Pancreas Cancer on Diagnostic Computed Tomography Scans As Well As Visually Occult Preinvasive Cancer on Prediagnostic Computed Tomography Scans
Automated Artificial Intelligence Model Trained on a Large Data Set Can Detect Pancreas Cancer on Diagnostic Computed Tomography Scans As Well As Visually Occult Preinvasive Cancer on Prediagnostic Computed Tomography Scans Open
View article: Medical Management of Autoimmune Pancreatitis
Medical Management of Autoimmune Pancreatitis Open
Corticosteroids are the cornerstone of medical management of both type 1 and type 2 autoimmune pancreatitis (AIP). The disease is universally steroid responsive and lack of response to corticosteroids should prompt reverification of the di…
View article: Epidemiology of Cystic Neoplasms of the Pancreas
Epidemiology of Cystic Neoplasms of the Pancreas Open
Pancreatic cystic lesions (PCL), which can be neoplastic or non-neoplastic, are being increasingly identified in asymptomatic patients on routine imaging studies, their prevalence increasing with age. Based on review of such studies the pr…
View article: Bounding box-based 3D AI model for user-guided volumetric segmentation of pancreatic ductal adenocarcinoma on standard-of-care CTs
Bounding box-based 3D AI model for user-guided volumetric segmentation of pancreatic ductal adenocarcinoma on standard-of-care CTs Open
View article: Management of Patients With Pancreatic Cancer Using the “Right Track” Model
Management of Patients With Pancreatic Cancer Using the “Right Track” Model Open
Pancreatic cancer is one of the few cancer types in the US with incidence and death rates continuing to rise. As the disease threatens to become the second leading cause of cancer-related deaths in the country, it is imperative to review t…
View article: Supplementary Figure Legends from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Supplementary Figure Legends from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Supplementary Figure Legends
View article: Figure S1 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9
Figure S1 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9 Open
Supplemental Figure 1 shows the predicted probability of cancer from the cross-validated MDM rForest model, demonstrating no significant difference in model performance based on tumor size, tumor location, presence of symptoms at the time …
View article: Supplementary Table 1 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Supplementary Table 1 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Supplementary Table 1. Pharmacological Inhibitors of Endocytic Pathways
View article: Data from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9
Data from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9 Open
Purpose:We have previously identified tissue methylated DNA markers (MDMs) associated with pancreatic ductal adenocarcinoma (PDAC). In this case–control study, we aimed to assess the diagnostic performance of plasma MDMs for PDAC.Experimen…
View article: Supplementary Fig. 1 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Supplementary Fig. 1 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Supplementary Fig. 1. NanoTracker results of PC-Exosome isolated from PC patient-derived cell lines and patient plasma. (A-B) PC-Exo isolated from a PC patient-derived cell line show the majority of microparticles are of exosomal size ([A]…
View article: Figure S2 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9
Figure S2 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9 Open
Supplemental Figure 2 shows the correlation between CA 19-9 values derived using study protocol and clinical laboratory values derived at Mayo Clinic.
View article: Data from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Data from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Purpose: Pancreatic cancer frequently causes diabetes. We recently proposed adrenomedullin as a candidate mediator of pancreatic β-cell dysfunction in pancreatic cancer. How pancreatic cancer–derived adrenomedullin reaches β cells r…
View article: Supplementary Fig. 3 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Supplementary Fig. 3 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Supplementary Fig. 3. Chlorpromazine and Nocodazole do not inhibit exosome internalization. INS-1 cells were treated with varying concentrations of chlorpromazine (A) or Nocodazole (C) for 30 minutes and 10 minutes, respectively. PKH67-dye…
View article: Supplementary Table 1 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Supplementary Table 1 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Supplementary Table 1. Pharmacological Inhibitors of Endocytic Pathways
View article: Figure S3 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9
Figure S3 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9 Open
Supplemental Figure 3 shows the distributions in plasma from controls and PDAC patients by stage of disease and standardized copy numbers of all MDMs other than HOXA1 and PRKCB.
View article: Figure S2 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9
Figure S2 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9 Open
Supplemental Figure 2 shows the correlation between CA 19-9 values derived using study protocol and clinical laboratory values derived at Mayo Clinic.
View article: Supplementary Figure Legends from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Supplementary Figure Legends from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Supplementary Figure Legends
View article: Supplementary Fig. 3 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Supplementary Fig. 3 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Supplementary Fig. 3. Chlorpromazine and Nocodazole do not inhibit exosome internalization. INS-1 cells were treated with varying concentrations of chlorpromazine (A) or Nocodazole (C) for 30 minutes and 10 minutes, respectively. PKH67-dye…
View article: Data from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Data from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Purpose: Pancreatic cancer frequently causes diabetes. We recently proposed adrenomedullin as a candidate mediator of pancreatic β-cell dysfunction in pancreatic cancer. How pancreatic cancer–derived adrenomedullin reaches β cells r…
View article: Figure S3 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9
Figure S3 from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9 Open
Supplemental Figure 3 shows the distributions in plasma from controls and PDAC patients by stage of disease and standardized copy numbers of all MDMs other than HOXA1 and PRKCB.
View article: Supplementary Fig. 1 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Supplementary Fig. 1 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction Open
Supplementary Fig. 1. NanoTracker results of PC-Exosome isolated from PC patient-derived cell lines and patient plasma. (A-B) PC-Exo isolated from a PC patient-derived cell line show the majority of microparticles are of exosomal size ([A]…
View article: Supplementary Data from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9
Supplementary Data from High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9 Open
Supplementary Tables and Figure Legends