Manjunatha M. Venkataswamy
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View article: Higher proportions of circulating CXCR3+ CCR6− Tfh cells as a hallmark of impaired CD4+ T-cell recovery in HIV-1-infected immunological non-responders
Higher proportions of circulating CXCR3+ CCR6− Tfh cells as a hallmark of impaired CD4+ T-cell recovery in HIV-1-infected immunological non-responders Open
Despite long-term suppressive antiretroviral therapy (ART), immune dysregulation due to impaired reconstitution of CD4+ T cells is a major hurdle for reducing morbidity and mortality in HIV-1-infected immunological non-responders (INRs, CD…
View article: Generation of induced pluripotent stem cell line, NIMHi013-A, from PBMCs of a female child with epilepsy carrying a novel SCN1A variant
Generation of induced pluripotent stem cell line, NIMHi013-A, from PBMCs of a female child with epilepsy carrying a novel SCN1A variant Open
The iPSC line NIMHi013-A was generated from peripheral blood mononuclear cells of a paediatric patient with drug resistant epilepsy. The proband was found to have a likely pathogenic missense variant in the SCN1A gene in heterozygous state…
View article: An ultrastructural and genomic study on the SARS-CoV-2 variant B.1.210 circulating during the first wave of COVID-19 pandemic in India
An ultrastructural and genomic study on the SARS-CoV-2 variant B.1.210 circulating during the first wave of COVID-19 pandemic in India Open
The SARS-CoV-2 variant B.1.210 virus isolated here showed ultrastructural features and cytopathogenesis similar to that of the virus reported during early phase of pandemic. Phylogenetic analysis showed that the isolated virus is closely r…
View article: Identification and Quantification of “Cancer Stem Cells” in Potentially Malignant and Malignant Disorders of Head and Neck Region: A Flow-Cytometric Study
Identification and Quantification of “Cancer Stem Cells” in Potentially Malignant and Malignant Disorders of Head and Neck Region: A Flow-Cytometric Study Open
Background: Cancer stem cells (CSCs) are subpopulation of cells existent in a cancerous mass of cells. These CSCs hijack the properties of stem cells like self-renewal as well as being resistant to any conventional cancer therapies. The ob…
View article: Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka
Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka Open
Karnataka, a state in south India, reported its first case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on March 8, 2020, more than a month after the first case was reported in India. We used a combination of c…
View article: Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis
Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis Open
The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in Mycobacterium tuberculosis, which encodes a component of a virulen…
View article: Epidemiology of SARS-CoV-2 infection in Karnataka State, South India: Transmission dynamics of symptomatic vs. asymptomatic infections
Epidemiology of SARS-CoV-2 infection in Karnataka State, South India: Transmission dynamics of symptomatic vs. asymptomatic infections Open
Background In this report, we describe the epidemiology of SARS-CoV-2 infection, specifically examining how the symptomatic persons drove the transmission in the state of Karnataka, India, during the lockdown phase. Methods The study inclu…
View article: Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka
Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka Open
An earlier version of this manuscript was removed owing to inclusion of confidential information relating to an individual
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Issue Information Open
dye (green).
View article: Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures
Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures Open
Comparing immune mechanisms prevailing in DENV-patients and virus-exposed healthy subjects in the Indian population to define critical elements of anti-viral immunity.
View article: An Arthropod Virus: Chikungunya its Pathophysiology and Herbal Treatment
An Arthropod Virus: Chikungunya its Pathophysiology and Herbal Treatment Open
Chikungunya is an infection caused by the chikungunya virus (CHIKV). The virus is spread between people by two types of mosquitos. Aedes albopictus and Aedes aegypti. They mainly bite during the day. CHIKV likely originated in Central/East…
View article: Alteration of T Cell Phenotypes in HIV‐Neurotuberculosis Coinfection
Alteration of T Cell Phenotypes in HIV‐Neurotuberculosis Coinfection Open
Background Neurotuberculosis is one of the commonest HIV associated opportunistic infections of the central nervous system in India. HIV‐TB coinfection may lead to altered frequencies of T cells, thereby influencing the course and progress…
View article: The Insidious Disease from Insects: Lyme Disease
The Insidious Disease from Insects: Lyme Disease Open
Lyme disease is medically described as occurring in three phases, each with distinctive symptoms. The first phase is early localized disease, which occurs three to 30 days after the tick bite that transmitted the infection. This stage is c…
View article: Spreading of Swine flu disease: Past and Present
Spreading of Swine flu disease: Past and Present Open
Swine Flu or the Influenza A (H1N1) flu, an highly contagious acute respiratory disease of the pigs, is caused by one of the numerous swine influenza A strains and is highly contagious. The transmission of the virus is from person-to-perso…
View article: Exploring Single-Cell Data with Deep Multitasking Neural Networks
Exploring Single-Cell Data with Deep Multitasking Neural Networks Open
Biomedical researchers are generating high-throughput, high-dimensional single-cell data at a staggering rate. As costs of data generation decrease, experimental design is moving towards measurement of many different single-cell samples in…
View article: Comparative sperm protein profiling in bulls differing in fertility and identification of phosphatidylethanolamine‐binding protein 4, a potential fertility marker
Comparative sperm protein profiling in bulls differing in fertility and identification of phosphatidylethanolamine‐binding protein 4, a potential fertility marker Open
Summary This study aimed to identify sperm proteomic signatures regulating sperm functions and fertility by: (i) comparing the sperm electrophoretic protein profiles and identifying the differentially abundant proteins among breeding bulls…
View article: Genotypic Characterisation of Mycobacterium tuberculosis Isolates from Tuberculous Meningitis Patients at a Tertiary Neurocare Centre in Southern India
Genotypic Characterisation of Mycobacterium tuberculosis Isolates from Tuberculous Meningitis Patients at a Tertiary Neurocare Centre in Southern India Open
We conclude that there is no apparent association between genotypes of MTB and propensity to infect CNS tissue.
View article: Cellular Immune Responses to Live Attenuated Japanese Encephalitis (JE) Vaccine SA14-14-2 in Adults in a JE/Dengue Co-Endemic Area
Cellular Immune Responses to Live Attenuated Japanese Encephalitis (JE) Vaccine SA14-14-2 in Adults in a JE/Dengue Co-Endemic Area Open
clinicaltrials.gov (NCT01656200).
View article: Human T cell responses to Japanese encephalitis virus in health and disease
Human T cell responses to Japanese encephalitis virus in health and disease Open
Japanese encephalitis (JE) virus (JEV) is an important cause of encephalitis in children of South and Southeast Asia. However, the majority of individuals exposed to JEV only develop mild symptoms associated with long-lasting adaptive immu…