Explanipedia

Generating active T1 transitions through mechanochemical feedback Open

Rastko Sknepnek, Ilyas Djafer-Cherif, Manli Chuai, Cornelis J. Weijer, Silke Henkes · 2023

Convergence–extension in embryos is controlled by chemical and mechanical signalling. A key cellular process is the exchange of neighbours via T1 transitions. We propose and analyse a model with positive feedback between recruitment of myo…

Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviours in the chick embryo Open

Manli Chuai, Guillermo Serrano Nájera, Mattia Serra, L. Mahadevan, Cornelis J. Weijer · 2021

The morphology of gastrulation driving the internalisation of the mesoderm and endoderm differs dramatically among vertebrate species. It ranges from involution of epithelial sheets of cells through a circular blastopore in amphibians to i…

A mechanochemical model recapitulates distinct vertebrate gastrulation modes Open

Mattia Serra, Guillermo Serrano Nájera, Manli Chuai, Vamsi Spandan, Cornelis J. Weijer , et al. · 2021

Gastrulation is a critical event in vertebrate morphogenesis driven by cellular processes, and characterized by coordinated multi-cellular movements that form the robust morphological structures. How these structures emerge in a developing…

Generating active T1 transitions through mechanochemical feedback Open

Rastko Sknepnek, Ilyas Djafer-Cherif, Manli Chuai, Cornelis J. Weijer, Silke Henkes · 2021

Convergence-extension in embryos is controlled by chemical and mechanical signalling. A key cellular process is the exchange of neighbours via T1 transitions. We propose and analyse a model with positive feedback between recruitment of myo…

Dynamic morphoskeletons in development Open

Mattia Serra, Sebastian J. Streichan, Manli Chuai, Cornelis J. Weijer, L. Mahadevan · 2020

Morphogenetic flows in developmental biology are characterized by the coordinated motion of thousands of cells that organize into tissues, naturally raising the question of how this collective organization arises. Using only the kinematics…

Zinc oxide nanoparticles exposure-induced oxidative stress restricts cranial neural crest development during chicken embryogenesis Open

Yu Yan, Wang Guang, Ju Huang, Yan Zhang, Xin Cheng , et al. · 2020

Measurement of junctional tension in epithelial cells at the onset of primitive streak formation in the chick embryo via non-destructive optical manipulation Open

Valentina Ferro, Manli Chuai, David McGloin, Cornelis J. Weijer · 2020

Directional cell intercalations of epithelial cells during gastrulation has, in several organisms, been shown to be associated with a planar cell polarity in the organisation of the actin-myosin cytoskeleton and is postulated to reflect di…

Measurement of junctional tension in epithelial cells at the onset of primitive streak formation in the chick embryo via non-destructive optical manipulation Open

Valentina Ferro, Manli Chuai, David McGloin, Cornelis J. Weijer · 2018

Oriented cell intercalations and cell shape changes are key determinants of large-scale epithelial cell sheet deformations occurring during gastrulation in many organisms. In several cases directional intercalation and cell shape changes h…

Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system Open

Guang Wang, Jianxin Liang, Lin-Rui Gao, Zhen-Peng Si, Xiao-tan Zhang , et al. · 2018

Gut microbiota‐derived endotoxin enhanced the incidence of cardia bifida during cardiogenesis Open

Jing Zhang, Guang Wang, Jia Liu, Linrui Gao, Meng Liu , et al. · 2017

Cytotoxicity and inflammation‐associated toxic responses could be induced by bacterial lipopolysaccharides (LPS) in vitro and in vivo, respectively. However, the mechanism involved in LPS‐induced cardiac malformation in prenatal fetus is s…

Ethanol exposure leads to disorder of blood island formation in early chick embryo Open

Guang Wang, Binzhen Chen, Chaojie Wang, Jing Zhang, Linrui Gao , et al. · 2017

Exposure to Excess Phenobarbital Negatively Influences the Osteogenesis of Chick Embryos Open

Yu Yan, Xin Cheng, Renhao Yang, He Li, Jianlong Chen , et al. · 2016

Phenobarbital is an antiepileptic drug that is widely used to treat epilepsy in a clinical setting. However, a long term of phenobarbital administration in pregnant women may produce side effects on embryonic skeletogenesis. In this study,…

Proper autophagy is indispensable for angiogenesis during chick embryo development Open

Wen-hui Lu, Yu-xun Shi, Zheng-lai Ma, Guang Wang, Langxia Liu , et al. · 2016

People have known that autophagy plays a very important role in many physiological and pathological events. But the role of autophagy on embryonic angiogenesis still remains obscure. In this study, we demonstrated that Atg7, Atg8 and Becli…

Dexamethasone Exposure Accelerates Endochondral Ossification of Chick Embryos<i>Via</i>Angiogenesis Open

Xin Cheng, Yu Yan, Jian-long Chen, Zheng-lai Ma, Ren-hao Yang , et al. · 2015

Dexamethasone (Dex) is widely used to treat chronic inflammatory diseases in the clinic. Increasingly, there is more attention being paid to the side effect of Dex. In this study, we investigated the involvement and mechanism of Dex exposu…

Autophagy is involved in ethanol-induced cardia bifida during chick cardiogenesis Open

Shuai Li, Guang Wang, Lin-Rui Gao, Wen-hui Lu, Xiao-yu Wang , et al. · 2015

Excess alcohol consumption during pregnancy has been acknowledged to increase the incidence of congenital disorders, especially the cardiovascular system. However, the mechanism involved in ethanol-induced cardiac malformation in prenatal …

Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation Open

Emil Rozbicki, Manli Chuai, Antti Karjalainen, Feifei Song, Helen Sang , et al. · 2015

Effects of Antitumor Drug Sorafenib on Chick Embryo Development Open

Yi-Sen Cheng, Xiaoyu Wang, Guang Wang, Yan Li, Yue‐Lei Chen , et al. · 2015

Sorafenib has been used as an oral anti‐cancer drug because of its ability to inhibit tumor growth. However, the pharmacological effect of sorafenib is still the lack of in vivo experimental evidence. Tumor and embryonic cells share some s…

Autophagy is involved in high glucose-induced heart tube malformation Open

Guang Wang, Wen-qing Huang, Shu-dan Cui, Shuai Li, Xiao-yu Wang , et al. · 2015

Both pre-gestational and gestational diabetes have an adverse impact on heart development, but little is known about the influence on the early stage of heart tube formation. Using early gastrulating chick embryos, we investigated the infl…

Autophagy is involved in high glucose-induced heart tube malformation Open

Guang Wang, Wen-Qing Huang, Shu-Dan Cui, Shuai Li, Xiaoyu Wang , et al. · 2015