Meng Guo
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View article: Synergistic Effect of Nitrogen Fertilizer Management on Rice Productivity and Quality
Synergistic Effect of Nitrogen Fertilizer Management on Rice Productivity and Quality Open
This study investigated how nitrogen fertilizer management influences the yield and grain quality of two rice cultivars, Nanjing 9108 (a late-maturing medium japonica) and Ming 1 Youzhenzhan (a three-line indica hybrid). Three field experi…
View article: Growth differentiation factor-15 may be a novel biomarker in pancreatic cancer: A review
Growth differentiation factor-15 may be a novel biomarker in pancreatic cancer: A review Open
Pancreatic cancer is a highly malignant and invasive gastrointestinal tumor that is often diagnosed at an advanced stage with a poor prognosis and high mortality. Currently, carbohydrate antigen199(CA199) is the only biomarker approved by …
View article: Lactobacillus paracasei ET-22 Suppresses Dental Caries by Regulating Microbiota of Dental Plaques and Inhibiting Biofilm Formation
Lactobacillus paracasei ET-22 Suppresses Dental Caries by Regulating Microbiota of Dental Plaques and Inhibiting Biofilm Formation Open
Dental caries is a common and multifactorial biofilm disease that is associated with dietary habits and microbiota. Among the various pathogens inducing caries, S. mutans is the most extensively studied. Promoting oral health with probioti…
View article: Comprehensive Characterization of B-Box Zinc Finger Genes in Citrullus lanatus and Their Response to Hormone and Abiotic Stresses
Comprehensive Characterization of B-Box Zinc Finger Genes in Citrullus lanatus and Their Response to Hormone and Abiotic Stresses Open
Plant B-BOX (BBX) zinc finger transcription factors play crucial roles in growth and development and the stress response. Although the BBX family has been characterized in various plants, systematic analysis in watermelon is still lacking.…
View article: Characterization of HSP70 family in watermelon (Citrullus lanatus): identification, structure, evolution, and potential function in response to ABA, cold and drought stress
Characterization of HSP70 family in watermelon (Citrullus lanatus): identification, structure, evolution, and potential function in response to ABA, cold and drought stress Open
Watermelon ( Citrullus lanatus ) as a crop with important economic value, is widely cultivated around the world. The heat shock protein 70 (HSP70) family in plant is indispensable under stress conditions. However, no comprehensive analysis…
View article: Autologous <i>ex vivo</i> expanded NK cells combined with PD-1 inhibitor improved ascitic fluid immune microenvironment of peritoneal metastatic pancreatic cancer: a case study.
Autologous <i>ex vivo</i> expanded NK cells combined with PD-1 inhibitor improved ascitic fluid immune microenvironment of peritoneal metastatic pancreatic cancer: a case study. Open
The presence of peritoneal metastasis in patients with pancreatic cancer is associated with poor prognosis. Chemotherapy and radiotherapy may result in poor prognosis in patients with pancreatic cancer. However, immunotherapy improves prog…
View article: Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway
Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway Open
Aberrant activation of the Wnt/β-catenin signaling pathway is implicated in most malignant cancers, especially in the initiation and progression of colorectal cancer (CRC). DKK4 is a classical inhibitory molecule of the Wnt/β-catenin pathw…
View article: Tomato salt tolerance mechanisms and their potential applications for fighting salinity: A review
Tomato salt tolerance mechanisms and their potential applications for fighting salinity: A review Open
One of the most significant environmental factors affecting plant growth, development and productivity is salt stress. The damage caused by salt to plants mainly includes ionic, osmotic and secondary stresses, while the plants adapt to sal…
View article: ADIRF expression reversely correlates with stage progression and involves keratinocyte differentiation in esophageal squamous cell carcinoma
ADIRF expression reversely correlates with stage progression and involves keratinocyte differentiation in esophageal squamous cell carcinoma Open
Background: Aberrant differentiation in esophageal mucosa was crucial for the carcinogenesis and development of esophageal squamous cell carcinoma (ESCC). However, few evidences elucidated the regulatory molecule during ESCC differentiatio…
View article: Large-Section Histopathology Can Better Indicate the Immune Microenvironment and Predict the Prognosis of Pancreatic Ductal Adenocarcinoma Than Small-Section Histopathology
Large-Section Histopathology Can Better Indicate the Immune Microenvironment and Predict the Prognosis of Pancreatic Ductal Adenocarcinoma Than Small-Section Histopathology Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor and is insensitive to radiotherapy and chemotherapy, as it is highly correlated with its complex tumor microenvironment (TME). A comprehensive description of PDAC’s immune…
View article: Silencing of ER-resident oxidoreductase PDIA3 inhibits malignant biological behaviors of multidrug-resistant gastric cancer
Silencing of ER-resident oxidoreductase PDIA3 inhibits malignant biological behaviors of multidrug-resistant gastric cancer Open
Glycosylation is a common posttranslational modification of proteins, which plays a role in the malignant transformation, growth, progression, chemoresistance, and immune response of tumors. Disulfide isomerase family A3 (PDIA3) specifical…
View article: Adaptive immunity-related gene expression profile is correlated with clinical phenotype in patients with acute myeloid leukemia
Adaptive immunity-related gene expression profile is correlated with clinical phenotype in patients with acute myeloid leukemia Open
This study has uncovered the expression profile of adaptive immunity-related genes in AML. The different gene expression patterns are not associated with survival, but are significantly correlated the FAB types. CLEC2B expression is low in…
View article: Adaptive immunity profiling associated with histological subtypes and postoperative survival in gastric cancer
Adaptive immunity profiling associated with histological subtypes and postoperative survival in gastric cancer Open
This study showed that the expressional patterns of adaptive immunity-related genes are closely related to the histological type of GC, and demonstrated that the expression of immune molecules is correlated to the prognosis. Our results ar…
View article: Angiogenesis related gene expression significantly associated with the prognostic role of an urothelial bladder carcinoma
Angiogenesis related gene expression significantly associated with the prognostic role of an urothelial bladder carcinoma Open
This study showed an integrated profile of angiogenesis-related genes and identified the different BLCA subgroups with favorable prognosis and poor prognosis depended on the expression pattern of angiogenesis-related genes. Furthermore, th…
View article: The Discovery of Breast Cancer Risk Gene and Establishment of Prediction Model Based on Estrogen Metabolism Regulation
The Discovery of Breast Cancer Risk Gene and Establishment of Prediction Model Based on Estrogen Metabolism Regulation Open
Background In this study, we aim to uncover the relationship between estrogen levels and the genetic polymorphism of estrogen metabolism-related enzymes with breast cancer (BC) and establish a risk prediction model based on polygenic risk …
View article: Prognosis of distal pancreatic cancers controlled by stage
Prognosis of distal pancreatic cancers controlled by stage Open
Patients with distal (body/tail) pancreatic cancer have been found to present worse outcome than patients with head cancer, which is generally attributed to the great proportion of advanced stages for body/tail cancers upon detection. Howe…
View article: Progress in Animal Models of Pancreatic Ductal Adenocarcinoma
Progress in Animal Models of Pancreatic Ductal Adenocarcinoma Open
As a common gastrointestinal tumor, the incidence of pancreatic cancer has been increasing in recent years. The disease shows multi-gene, multi-step complex evolution from occurrence to dissemination. Furthermore, pancreatic cancer has an …
View article: Prognostic Roles of Central Carbon Metabolism–Associated Genes in Patients With Low-Grade Glioma
Prognostic Roles of Central Carbon Metabolism–Associated Genes in Patients With Low-Grade Glioma Open
Purpose: Metabolic alterations are crucial for tumor progression and response to therapy. The comprehensive model of combined central carbon metabolism-associated genes that contribute to the outcomes of glioma and astrocytoma is not well …
Identification of serum microRNAs as diagnostic biomarkers for schizophrenia Open
The study concludes that the two miRNAs combinations have the potential to be used as biomarkers for schizophrenia diagnoses. The finding may be conducive to overcoming the dilemmas faced by current schizophrenia diagnosis.
View article: A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer
A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer Open
The anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase, is responsible for the transition from metaphase to anaphase and the exit from mitosis. The anaphase promoting complex subunit 10 (APC10), a subu…
TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 Open
Macroautophagy/autophagy is a multistep cellular process that sequesters cytoplasmic components for lysosomal degradation. BECN1/Beclin1 is a central protein that assembles cofactors for the formation of a BECN1-PIK3C3-PIK3R4 complex to tr…