Explanipedia

Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma 4365 Open

Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Emma Goddery, Peter R. Strege , et al. · 2025

Description In the tumor microenvironment of glioblastoma, myeloid cells act as a double-edged sword—they are a major cellular component suppressing the immune response while serving as a promising therapeutic target. Our study sheds light…

Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration Open

Manling Xie, Yue Liang, Alessandra S. Miller, Praveen N. Pallegar, Anthony D. Umpierre , et al. · 2025

Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma Open

Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Katayoun Ayasoufi, Emma Goddery , et al. · 2024

In the tumor microenvironment of glioblastoma, myeloid cells act as a double-edged sword—they are a major cellular component modulating the immune response while presenting a potential therapeutic target. Our study highlights the voltage-g…

Rod-shaped microglia interact with neuronal dendrites to regulate cortical excitability in TDP-43 related neurodegeneration Open

Manling Xie, Alessandra S. Miller, Praveen N. Pallegar, Anthony D. Umpierre, Yue Liang , et al. · 2024

Motor cortical hyperexcitability is well-documented in the presymptomatic stage of amyotrophic lateral sclerosis (ALS). However, the mechanisms underlying this early dysregulation are not fully understood. Microglia, as the principal immun…

Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis Open

Anthony D. Umpierre, Bohan Li, Katayoun Ayasoufi, Whitney L. Simon, Shunyi Zhao , et al. · 2024

Impaired microglial phagocytosis promotes seizure development Open

Dale B. Bosco, Václav Křemen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang , et al. · 2024

In the central nervous system, triggering receptor expressed on myeloid cells 2 (TREM2) is exclusively expressed by microglia and is critical for microglial proliferation, migration, and phagocytosis. TREM2 plays an important role in neuro…

TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas Open

Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Wenjing Zhang, Yuzhou Chang , et al. · 2023

Background Myeloid cells comprise up to 50% of the total tumor mass in glioblastoma (GBM) and have been implicated in promoting tumor progression and immunosuppression. Modulating the response of myeloid cells to the tumor has emerged as a…

Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms Open

Manling Xie, Praveen N. Pallegar, Sebastian Parusel, Aivi T. Nguyen, Long‐Jun Wu · 2023

Chemogenetic manipulation of CX3CR1+ cells transiently induces hypolocomotion independent of microglia Open

Shunyi Zhao, Jiaying Zheng, Lingxiao Wang, Anthony D. Umpierre, Sebastian Parusel , et al. · 2023

Microglial P2Y6calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis Open

Anthony D. Umpierre, Bohan Li, Katayoun Ayasoufi, Shunyi Zhao, Manling Xie , et al. · 2023

SUMMARY Microglial calcium signaling is rare in a baseline state but shows strong engagement during early epilepsy development. The mechanism and purpose behind microglial calcium signaling is not known. By developing an in vivo UDP fluore…

TREM2 mediates MHCII-associated CD4+T cell response against gliomas Open

Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Wenjing Zhang, Yuzhou Chang , et al. · 2023

Triggering receptor expressed on myeloid cells 2 (TREM2) was recently highlighted as a novel immune suppressive marker in peripheral tumors. The aim of this study was to characterize TREM2 expression in gliomas and investigate its contribu…

APOE2 Exacerbates TDP‐43 Related Toxicity in the Absence of Alzheimer Pathology Open

Axel Meneses, Shunsuke Koga, Zonghua Li, Justin O’Leary, Fuyao Li , et al. · 2022

Objective Recent evidence supports a link between increased TDP‐43 burden and the presence of an APOE4 gene allele in Alzheimer's disease (AD); however, it is difficult to conclude the direct effect of APOE on TDP‐43 pathology due to the p…

Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity Open

Nan Gu, Min‐Hee Yi, Madhuvika Murugan, Manling Xie, Sebastian Parusel , et al. · 2022

Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia Open

Na Zhao, Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng , et al. · 2022

TREM2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for Alzheimer’s disease (AD). As microglial responses modulated by TREM2 are central to AD pathogenesis, enhancing TREM2 signaling has been explore…

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration Open

Manling Xie, Yong Liu, Shunyi Zhao, Lingxin Zhang, Dale B. Bosco , et al. · 2021

Microglial TREM2 in amyotrophic lateral sclerosis Open

Manling Xie, Shunyi Zhao, Dale B. Bosco, Aivi T. Nguyen, Long‐Jun Wu · 2021

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is an aggressive motor neuron degenerative disease characterized by selective loss of both upper and lower motor neurons. The mechanisms underlying disease initiation…

A Functional Variant in SEPP1 Interacts With Plasma Selenium Concentrations on 3-Year Lipid Changes: A Prospective Cohort Study Open

Li Zhou, Xiaoling Liang, Manling Xie, Jiawei Yin, Yue Huang , et al. · 2021

Background: Excess selenium has been related with adverse lipid levels in previous epidemiological studies. Meanwhile, a functional variant in SEPP1 (encodes selenoprotein P), namely rs7579, has been suggested to modulate lipid metabolism.…

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration Open

Manling Xie, Yong Liu, Shunyi Zhao, Lingxin Zhang, Dale B. Bosco , et al. · 2021

Triggering receptor expressed on myeloid cell 2 (TREM2) is a surface receptor that, in the central nervous system, is exclusively expressed on microglia. TREM2 variants have been linked to increased risk for neurodegenerative diseases, but…

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration Open

Manling Xie, Yong Liu, Shuyi Zhao, Lingxin Zhang, Dale B. Bosco , et al. · 2021

Triggering receptor expressed on myeloid cell 2 (TREM2) is a surface receptor that, in the central nervous system, is exclusively expressed on microglia. TREM2 variants have been linked to increased risk for neurodegenerative diseases, but…

The complement C3‐C3aR pathway mediates microglia–astrocyte interaction following status epilepticus Open

Yujia Wei, Tingjun Chen, Dale B. Bosco, Manling Xie, Jiaying Zheng , et al. · 2020

Gliosis is a histopathological characteristic of epilepsy that comprises activated microglia and astrocytes. It is unclear whether or how crosstalk occurs between microglia and astrocytes in the evolution of epilepsy. Here, we report in a …

Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice Open

Min‐Hee Yi, Yong Liu, Kevin Liu, Tingjun Chen, Dale B. Bosco , et al. · 2020

Microglial depletion aggravates the severity of acute and chronic seizures in mice Open

Wen‐Ning Wu, Yujiao Li, Yujia Wei, Dale B. Bosco, Manling Xie , et al. · 2020

Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice Open

Min‐Hee Yi, Yong Liu, Kevin Liu, Tingjun Chen, Dale B. Bosco , et al. · 2020

Microglia play an important role in the central sensitization and chronic pain. However, a direct connection between microglial function and the development of neuropathic pain in vivo remains incompletely understood. To address this issue…

Two Cases of Pulmonary Enteric Adenocarcinoma in One Family Open

Manling Xie, X. Li · 2020

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components Open

Li Zhou, Cheng Luo, Jiawei Yin, Yalun Zhu, Peiyun Li , et al. · 2020

The relationship between selenium and metabolic syndrome (MetS) has been discussed controversially, and limited studies have examined the associations of single nucleotide polymorphisms in selenoproteins genes with MetS. Hence, to examine …

Chemogenetic Manipulation of Microglia Inhibits Neuroinflammation and Neuropathic Pain in Mice Open

Min‐Hee Yi, Yu Liu, Kevin Liu, Tingjun Chen, Dale B. Bosco , et al. · 2020

Spinal Microglia Contribute to Sustained Inflammatory Pain via Amplifying Neuronal Activity Open

Nan Gu, Min‐Hee Yi, Madhuvika Murugan, Manling Xie, Jiyun Peng , et al. · 2019

SUMMARY Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial processes interact with neuronal elements constantly on the order of minutes. The functional significance of this acute microglia-neuron inte…

Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections Open

Mingshu Mo, Ukpong B. Eyo, Manling Xie, Jiyun Peng, Dale B. Bosco , et al. · 2019

Seizures are common in humans with various etiologies ranging from congenital aberrations to acute injuries that alter the normal balance of brain excitation and inhibition. A notable consequence of seizures is the induction of aberrant ne…

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice Open

Jiyun Peng, Yong Liu, Anthony D. Umpierre, Manling Xie, Dai‐Shi Tian , et al. · 2019

The P2Y12 receptor (P2Y12R) is a purinoceptor that is selectively expressed in microglia in the central nervous system. As a signature receptor, microglial P2Y12R mediates process chemotaxis towards ADP/ATP gradients and is engaged in seve…

δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer’s disease Open

Zhentao Zhang, Xiaoguang Li, Zhi-Hao Wang, Mingke Song, Shan Ping Yu , et al. · 2018

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