Explanipedia

A genome-wide CRISPR screen identifies the TNRC18 gene locus as a regulator of inflammatory signaling Open

Fedik Rahimov, Sujana Ghosh, Manman Shi, Daniel Verduzco, Sanjana Singh , et al. · 2025

Interleukin-1β (IL-1β) is dysregulated in chronic inflammatory diseases, yet the genetic factors influencing IL-1β production remain largely unknown. Myeloid-derived cells are the primary producers of IL-1β, which prompted a genome-wide CR…

Astragaloside IV relieves passive heymann nephritis and podocyte injury by suppressing the TRAF6/NF-κb axis Open

Yuhua Ma, Yu‐Wen Hu, Yilin Ruan, Xiaocheng Jiang, Min Zhao , et al. · 2024

The pathogenesis of membranous nephropathy (MN) involves podocyte injury that is attributed to inflammatory responses induced by local immune deposits. Astragaloside IV (AS-IV) is known for its robust anti-inflammatory properties. Here, we…

Manipulating the electronic structure of platinum via alloying with ruthenium to boost photocatalytic selective hydrogenation with water as a proton source Open

Manman Shi, Dian Luo, Peng Wu, Yarong Shen, Jieding Wei , et al. · 2024

Insight into the Correlation between Total Ginkgotoxin and Tree Ages, Geographical Locations, and Climatic Factors Open

Wen Zhang, Manman Shi, Guobin Jiang, Fuliang Cao, Erzheng Su · 2024

Single-cell RNA sequencing shows the immune cell landscape in the kidneys of patients with idiopathic membranous nephropathy Open

Manman Shi, Yuxin Wang, Huan Zhang, Zicheng Ling, Xue Chen , et al. · 2023

Idiopathic membranous nephropathy (IMN) is a leading pathological type of the adult primary nephrotic syndrome. Some patients develop end-stage renal disease due to poor response to treatment with steroid and immunosuppressive agents. In o…

A systematic review of the applicability of emergency department assessment of chest pain score‐accelerated diagnostic protocol for risk stratification of patients with chest pain Open

Minghu Wang, Zhiwei Hu, Lihui Miao, Manman Shi, Qiang Gao · 2023

The emergency department assessment of chest pain score‐accelerated diagnostic protocol (EDACS‐ADP) are commonly used for risk stratification in undifferentiated patients with acute chest pain. This systematic review aimed to investigate E…

Species-Level Characterization of the Microbiome in Breast Tissues with Different Malignancy and Hormone-Receptor Statuses Using Nanopore Sequencing Open

Lan Luo, Aisi Fu, Manman Shi, Jiawei Hu, Deguang Kong , et al. · 2023

Unambiguous evidence indicates that microbes are closely linked to various human diseases, including cancer. Most prior work investigating the microbiome of breast tissue describes an association between compositional differences of microb…

Fangji Huangqi Decoction Ameliorates Membranous Nephropathy Through the Upregulation of Bnip3-Mediated Mitophagy Open

Yuxin Wang, Yuhua Ma, Yanrong Ke, Xiaocheng Jiang, Jian Liu , et al. · 2023

Assessing the Impact of Continuous Vaccination and Voluntary Isolation on the Dynamics of COVID-19: A Mathematical Optimal Control of SEIR Epidemic Model Open

Yue Yu, Manman Shi, Manfeng Hu, Jingxiang Zhang · 2022

In order to study the impact of continuous vaccination and voluntary isolation for the COVID-19, a susceptible-exposed-infected-recovered-quarantine-vaccines (SEIR-QV) model is proposed. A basic regeneration number R 0 is defined t…

A Validation Study Comparing Risk Prediction Models of IgA Nephropathy Open

Yan Ouyang, Zhanzheng Zhao, Guisen Li, Huimin Luo, Feifei Xu , et al. · 2021

We aimed to validate three IgAN risk models proposed by an international collaborative study and another CKD risk model generated by an extended CKD cohort with our multicenter Chinese IgAN cohort. Biopsy-proven IgAN patients with an eGFR …

Corrigendum to Shi M, Yu S, Ouyang Y, et al. Increased lifetime risk of ESRD in familial IgA nephropathy. Kidney Int Rep. 2021;6:91-100. Open

Manman Shi, Shuwen Yu, Yan Ouyang, Yuanmeng Jin, Zijin Chen , et al. · 2021

[This corrects the article DOI: 10.1016/j.ekir.2020.10.015.].

Increased Lifetime Risk of ESRD in Familial IgA Nephropathy Open

Manman Shi, Shuwen Yu, Yan Ouyang, Yuanmeng Jin, Zijin Chen , et al. · 2020

Familial IgAN cases had poorer renal outcomes and less gender differences compared with sporadic cases. These findings provide evidence that familial disease represent a distinct subtype of more progressive IgAN. Early diagnosis could impr…

PPARγ and Its Agonists in Chronic Kidney Disease Open

Yuhua Ma, Manman Shi, Yuxin Wang, Jian Liu · 2020

Chronic kidney disease (CKD) has become a global healthcare issue. CKD can progress to irreversible end-stage renal diseases (ESRD) or renal failure. The major risk factors for CKD include obesity, diabetes, and cardiovascular diseases. Un…

A Rare Genetic Defect of MBL2 Increased the Risk for Progression of IgA Nephropathy Open

Yan Ouyang, Li Zhu, Manman Shi, Shuwen Yu, Yuanmeng Jin , et al. · 2019

The aim of this study was to investigate the association between lectin pathway-related genetic variations and progression in IgA nephropathy. Biopsy-proven IgAN patients with eGFR ≥15 ml/min/1.73 m² at baseline and a minimum fo…

IgA Nephropathy Susceptibility Loci and Disease Progression Open

Manman Shi, Yan Ouyang, Mingxin Yang, Meng Yang, Xiaoyan Zhang , et al. · 2018

Background and objectives At least 20 susceptibility loci of IgA nephropathy have been identified by genome-wide association studies to date. Whether these loci were associated with disease progression is unclear. Design, setting, particip…

A validation study of crescents in predicting ESRD in patients with IgA nephropathy Open

Xiaoyan Zhang, Sufang Shi, Yan Ouyang, Meng Yang, Manman Shi , et al. · 2018

SP096STUDY ON MUTATIONS OF CHINESE PATIENTS WITH LIPOPROTEIN GLOMERULOPATHY Open

Mingxin Yang, Xiaoxia Pan, Yunzi Liu, Manman Shi, Xialian Yu , et al. · 2018

INTRODUCTION AND AIMS: Lipoprotein glomerulopathy(LPG)is a unique and rare disorder of renal lipidosis.It is characterized by lipoprotein thrombi in glomeruli.LPG was found to be due to mutations of the APOE gene.15novel APOE variants have…

SaO019COMBINED VARIATIONS IN COMPLEMENT LECTIN PATHWAY SYNERGISTICALLY ACCELERATE PROGRESSION IN IGA NEPHROPATHY Open

Yan Ouyang, Meng Yang, Xiaoyan Zhang, Manman Shi, Xiaoxia Pan , et al. · 2018

INTRODUCTION AND AIMS: Conflicting data exists on the role of complement lectin pathway and its recognition molecules in the disease progression of IgA nephropathy (IgAN), and the underlying mechanism is not elucidated.The aim of this stud…

SP404RISK EQUATIONS FOR PREDICTING ESRD IN IGA NEPHROPATHY:MULTI-CENTER RISK ASSESSMENT STUDY IN CHINESE Open

Jingyuan Xie, Lv Jicheng, Weiming Wang, LI Gui-sen, Zhangsuo Liu , et al. · 2018

FP156COMBINED EFFECT OF ESTABLISHED IGA NEPHROPATHY SUSCEPTIBILITY LOCI ON DISEASE PROGRESSION Open

Manman Shi, Yan Ouyang, Mingxin Yang, Meng Yang, Xiaoyan Zhang , et al. · 2018

cohort.

High-quality-draft genomic sequence of Paenibacillus ferrarius CY1T with the potential to bioremediate Cd, Cr and Se contamination Open

Jingxin Li, Wei Guo, Manman Shi, Yajing Cao, Gejiao Wang · 2017

Paenibacillus ferrarius CY1 T (= KCTC 33419 T = CCTCC AB2013369 T ) is a Gram-positive, aerobic, endospore-forming, motile and rod-shaped bacterium isolated from iron mineral soil. This bacterium reduces sulfate (SO 4 2− ) to S 2− , which …

ABO blood type is associated with renal outcomes in patients with IgA nephropathy Open

Meng Yang, Jingyuan Xie, Yan Ouyang, Xiaoyan Zhang, Manman Shi , et al. · 2017

ABO blood group antigens have been reported to be associated with inflammation and infections which have been largely implicated in the onset and progression of immune-mediated diseases. This study aimed to evaluate the association between…

Abiotic and biotic factors responsible for antimonite oxidation in Agrobacterium tumefaciens GW4 Open

Jingxin Li, Yang Birong, Manman Shi, Kai Yuan, Wei Guo , et al. · 2017

Antimonite [Sb(III)]-oxidizing bacteria can transform the toxic Sb(III) into the less toxic antimonate [Sb(V)]. Recently, the cytoplasmic Sb(III)-oxidase AnoA and the periplasmic arsenite [As(III)] oxidase AioAB were shown to responsible f…

The metabolic pathways for carbohydrates, phosphonate and phosphinate, nucleotide and amino acids influenced by Sb(III) in A. tumefaciens GW4. Open

Jingxin Li, Yang Birong, Manman Shi, Kai Yuan, Wei Guo , et al. · 2017

Red text indicates the up-regulated genes, green text indicates the down-regulated genes. The dashed vector arrows indicate potential pathways that involve more than one intermediates and genes but none of which could be identified in the …

A proposed model of bacterial energy metabolism in response to Sb(III) in A. tumefaciens GW4. Open

Jingxin Li, Yang Birong, Manman Shi, Kai Yuan, Wei Guo , et al. · 2017

The energy generated from the process of Sb(III) oxidation was used to (1) Sb(III) efflux; (2) Pi or Sb(V) transportation; (3) G3P transportation; (4) protein refolding; (5) phosphonate metabolism; (6) DNA repair; (7) flagellum assemblage …

Information of the proteins/genes with different expression ratio in proteomics and qRT-PCR. Open

Jingxin Li, Yang Birong, Manman Shi, Kai Yuan, Guo Wei , et al. · 2017

Information of the proteins/genes with different expression ratio in proteomics and qRT-PCR.

Effects upon metabolic pathways and energy production by Sb(III) and As(III)/Sb(III)-oxidase gene aioA in Agrobacterium tumefaciens GW4 Open

Jingxin Li, Yang Birong, Manman Shi, Kai Yuan, Wei Guo , et al. · 2017

Agrobacterium tumefaciens GW4 is a heterotrophic arsenite [As(III)]/antimonite [Sb(III)]-oxidizing strain. The As(III) oxidase AioAB is responsible for As(III) oxidation in the periplasm and it is also involved in Sb(III) oxidation in Agro…

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