Manman Su
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View article: Amniotic mesenchymal stem cells attenuate diabetic cardiomyopathy by inhibiting pyroptosis via modulation of the TLR4/NF-κb/NLRP3 pathway
Amniotic mesenchymal stem cells attenuate diabetic cardiomyopathy by inhibiting pyroptosis via modulation of the TLR4/NF-κb/NLRP3 pathway Open
Diabetic cardiomyopathy (DCM) is a specific type of cardiac dysfunction in diabetic patients, currently has no effective therapies. The TLR4 signaling pathway, activated through MyD88 and NF-κB, plays a critical role in DCM by triggering t…
View article: Correlation between sleep and multimorbidity in community-dwelling older adults in Hunan Province: a cross-sectional study
Correlation between sleep and multimorbidity in community-dwelling older adults in Hunan Province: a cross-sectional study Open
Background The aim of this study was to provide global estimates of the prevalence of sleep quality and chronic diseases and to analyze the correlation between sleep and multimorbidity in community-dwelling older adults (≥65 years) in Chin…
View article: Targeting Lung Damage: Amniotic Mesenchymal Stem Cells Mitigate Lipopolysaccharide-Induced Acute Lung Injury via Multiple Signaling Pathways
Targeting Lung Damage: Amniotic Mesenchymal Stem Cells Mitigate Lipopolysaccharide-Induced Acute Lung Injury via Multiple Signaling Pathways Open
Acute lung injury (ALI) is a life-threatening condition triggered by pneumonia, viral infections, or physical trauma. It manifests clinically as progressive respiratory failure and refractory hypoxemia. Using a lipopolysaccharide (LPS)-ind…
View article: Research Progress of Bioactive Components in Sanghuangporus spp.
Research Progress of Bioactive Components in Sanghuangporus spp. Open
The species in Sanghuangporus are a group of edible mushrooms with a long history of oral use in East Asia as a health-improvement method. They should be classified under the genus Sanghuangporus rather than mistakenly in Phellinus or Inon…
View article: CD36: The Bridge between Lipids and Tumors
CD36: The Bridge between Lipids and Tumors Open
It has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs…
View article: Silencing LY6D Expression Inhibits Colon Cancer in Xenograft Mice and Regulates Colon Cancer Stem Cells’ Proliferation, Stemness, Invasion, and Apoptosis via the MAPK Pathway
Silencing LY6D Expression Inhibits Colon Cancer in Xenograft Mice and Regulates Colon Cancer Stem Cells’ Proliferation, Stemness, Invasion, and Apoptosis via the MAPK Pathway Open
This study explored the role of lymphocyte antigen 6 family member D (LY6D) in colon cancer stem cells’ (CCSCs) proliferation and invasion. LY6D was knocked down using siRNA, and the down-regulation of LY6D was verified using Western blott…
View article: Association between Sleep and Multimorbidity in Community-Dwelling Older Adults in Hunan Province: A Cross-sectional Study
Association between Sleep and Multimorbidity in Community-Dwelling Older Adults in Hunan Province: A Cross-sectional Study Open
Background The purpose of this study was to estimate the prevalence of sleep quality and chronic disease conditions, and to analyze the association between sleep and multimorbidity among community-dwelling older adults in China. Methods Th…
View article: Current status and influencing factors of self-management in knee joint discomfort among middle-aged and elderly people: a cross-sectional study
Current status and influencing factors of self-management in knee joint discomfort among middle-aged and elderly people: a cross-sectional study Open
View article: Relationship between knee joint discomfort, self-management behavior, and quality of life in the middle-aged and elderly people in China: A cross-sectional study
Relationship between knee joint discomfort, self-management behavior, and quality of life in the middle-aged and elderly people in China: A cross-sectional study Open
Background The aim of this study was to describe the knee joint discomfort, self-management behavior, and quality of life (QoL) in the middle-aged and elderly people in China and to clarify the relationship between the knee joint discomfor…
View article: Non-pharmacological interventions for the elderly with psychogenic insomnia: A Scoping Review Protocol
Non-pharmacological interventions for the elderly with psychogenic insomnia: A Scoping Review Protocol Open
Background: The elderly grow as age, sleep quality becomes worse, and psychogenic insomnia occupies a large proportion, which can lead to cognitive impairment and an increased risk of cardiovascular disease, even leading to suicide. It als…
View article: Correlation between PTSD and sleep quality in community-dwelling elderly adults in Hunan province of China
Correlation between PTSD and sleep quality in community-dwelling elderly adults in Hunan province of China Open
Background To understand the occurrence of post-traumatic stress disorder (PTSD) and the current status of sleep quality among community-dwelling elderly adults in Hunan Province of China, to explore the correlation between the two, and to…
View article: Salinomycin-Loaded High-Density Lipoprotein Exerts Promising Anti-Ovarian Cancer Effects by Inhibiting Epithelial–Mesenchymal Transition
Salinomycin-Loaded High-Density Lipoprotein Exerts Promising Anti-Ovarian Cancer Effects by Inhibiting Epithelial–Mesenchymal Transition Open
S-HDL had stronger anti-ovarian cancer effects than unencapsulated Sal. Thus, it may be a potential agent for ovarian cancer treatment in the future.
View article: The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b
The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b Open
Coronavirus disease 2019 (COVID-19) is a current global health threat caused by SARS-CoV-2. The innate immune response such as type I IFN (IFN-I) is the first line of host defense against viral infections, whereas SARS-CoV-2 proteins antag…
View article: Synthesis and Characterization of Salinomycin-Loaded High-Density Lipoprotein and Its Effects on Cervical Cancer Cells and Cervical Cancer Stem Cells
Synthesis and Characterization of Salinomycin-Loaded High-Density Lipoprotein and Its Effects on Cervical Cancer Cells and Cervical Cancer Stem Cells Open
S-HDL can effectively target and eliminate CCCs and CCSCs, which is a potential drug for the treatment of cervical cancer.
View article: The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis
The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis Open
Coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus that has spread rapidly around the world, leading to high mortality because of multiple organ dysfunction; however, its underlying molecular mechanism is unkno…
View article: <i>MicroRNA-183</i>attenuates osteoarthritic pain by inhibiting the<i>TGFα</i>-mediated<i>CCL2</i>/<i>CCR2</i>signalling axis
<i>MicroRNA-183</i>attenuates osteoarthritic pain by inhibiting the<i>TGFα</i>-mediated<i>CCL2</i>/<i>CCR2</i>signalling axis Open
Aims MicroRNA-183 ( miR-183) is known to play important roles in osteoarthritis (OA) pain. The aims of this study were to explore the specific functions of miR-183 in OA pain and to investigate the underlying mechanisms. Methods Clinical s…
View article: Enhanced anticancer effect of oncostatin M combined with salinomycin in CD133+ HepG2 liver cancer cells
Enhanced anticancer effect of oncostatin M combined with salinomycin in CD133+ HepG2 liver cancer cells Open
Oncostatin M (OSM) induces the differentiation of liver cancer stem cells (LCSCs) and increases sensitivity to the chemotherapeutic agent 5-fluorouracil, whereas salinomycin (Sal) induces apoptosis in cancer stem cells and inhibits the pro…
View article: Long non-coding RNAs on the stage of cervical cancer
Long non-coding RNAs on the stage of cervical cancer Open
Cervical cancer is one of most malignant gynecological tumors. However, effective means for diagnosing and treating cervical cancer have yet to be identified. A few decades ago, long non-coding RNAs (lncRNAs) were regarded as useless parts…
View article: Expression and purification of recombinant ATF-mellitin, a new type fusion protein targeting ovarian cancer cells, in P. pastoris
Expression and purification of recombinant ATF-mellitin, a new type fusion protein targeting ovarian cancer cells, in P. pastoris Open
Melittin is well known to possess cytolytic activity with wide-spectrum lytic properties and its potential use as an agent to treat several types of cancer has been tested. Due to the non-specific toxicity, melittin can impair not only can…
View article: Preparation and functional characterization of human vascular endothelial growth factor-melittin fusion protein with analysis of the antitumor activity in vitro and in vivo
Preparation and functional characterization of human vascular endothelial growth factor-melittin fusion protein with analysis of the antitumor activity in vitro and in vivo Open
Vascular endothelial growth factor and its tyrosine kinase receptors have been identified as key mediators of the regulation of pathologic blood vessel growth and maintenance in the promotion of angiogenesis and tumor growth. Therefore, an…
View article: Expression and activity analysis of a new fusion protein targeting ovarian cancer cells
Expression and activity analysis of a new fusion protein targeting ovarian cancer cells Open
The aim of the present study was to develop a new therapeutic drug to improve the prognosis of ovarian cancer patients. Human urokinase-type plasminogen activator (uPA)17-34-kunitz-type protease inhibitor (KPI) eukaryotic expression vector…