Manmohan Singh
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View article: Quantitative comparison between optical coherence elastography, ultrasound-based shear wave elastography, and Brillouin imaging
Quantitative comparison between optical coherence elastography, ultrasound-based shear wave elastography, and Brillouin imaging Open
Optical elastography is rapidly evolving for assessing tissue biomechanical properties, and these techniques are now reaching technical maturity, resulting in large-scale clinical studies. However, a lack of extensive research on intra- an…
View article: ALK5 inhibitor impact on bleomycin-induced systemic sclerosis mouse model via multifunctional optical coherence tomography
ALK5 inhibitor impact on bleomycin-induced systemic sclerosis mouse model via multifunctional optical coherence tomography Open
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis, vascular dysfunction, and immune dysregulation, leading to significant morbidity and mortality. Noninvasive imaging techniques are critical for monitoring …
View article: Assessment of Skin in Patients With Systemic Sclerosis Using High‐Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters
Assessment of Skin in Patients With Systemic Sclerosis Using High‐Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters Open
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large‐scale comparison of US‐based assessment with histologic markers of skin fibrosis has not been reporte…
View article: Optical coherence elastography detects increased corneal stiffness in nonhuman primates with experimental glaucoma
Optical coherence elastography detects increased corneal stiffness in nonhuman primates with experimental glaucoma Open
These results show the potential of wave-based OCE methods for assessing stiffness changes in the cornea caused by remodeling due to chronic pressure elevation.
View article: Quantifying age and spatial variations of bone marrow elasticity with noncontact optical coherence elastography
Quantifying age and spatial variations of bone marrow elasticity with noncontact optical coherence elastography Open
These findings show that OCE is promising for mapping the stiffness of the intact bone marrow and could be used for minimally invasive clinical applications.
View article: In Vivo Safety Evaluation of Acoustic Radiation Force for Optical Coherence Elastography of the Crystalline Lens
In Vivo Safety Evaluation of Acoustic Radiation Force for Optical Coherence Elastography of the Crystalline Lens Open
This study is an important step toward the translation of the technology for ARF elastography of the crystalline lens, for studies on the mechanism of presbyopia, and to enable the assessment of new presbyopia treatments relying on lens so…
View article: Comparison of monopolar and bipolar stimulation protocol for mapping of motor cortex
Comparison of monopolar and bipolar stimulation protocol for mapping of motor cortex Open
Objectives: Direct electrical cortical stimulation is the gold standard technique for intraoperative mapping of the motor cortex. The stimulation can be done in monopolar or bipolar configuration and with high or low-frequency stimulation …
View article: Depth‐Resolved Attenuation Coefficient Quantification During Murine Embryonic Brain Development
Depth‐Resolved Attenuation Coefficient Quantification During Murine Embryonic Brain Development Open
Brain development is a highly regulated process with significant morphological and functional transformations during early embryogenesis. Here, we quantified the optical attenuation coefficient (OAC) during murine embryonic brain developme…
View article: Multimodal optical coherence tomography and two-photon light sheet fluorescence microscopy for embryo imaging
Multimodal optical coherence tomography and two-photon light sheet fluorescence microscopy for embryo imaging Open
The co-alignment of the OCT and 2P-LSFM systems enables simple image registration and high-throughput multimodal imaging.
View article: The use of aqueous humor cfDNA for low-pass whole genome sequencing as a clinical test to identify intraocular retinoblastoma recurrence
The use of aqueous humor cfDNA for low-pass whole genome sequencing as a clinical test to identify intraocular retinoblastoma recurrence Open
Objective: Patients with retinoblastoma (RB) require serial examinations under anesthesia (EUA) to assess for response to treatment and disease recurrence. Monitoring for disease recurrence is complicated in patients with loss of fundoscop…
View article: Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography
Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography Open
Our results indicate that OCT and its extensions effectively analyze dermal fibrosis. OCE revealed increased stiffness in fibrotic skin, OCTA showed vessel dilation, and OCT noted morphological changes in fibrosis tissue.
View article: Determinants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography
Determinants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography Open
This work demonstrates the feasibility of air-pulse stimulation for robust OCE measurements of corneal stiffness in vivo for disease detection and therapy evaluation.
View article: Impact of adjuvant therapy on survival in treatment of CNS hemangiopericytomas
Impact of adjuvant therapy on survival in treatment of CNS hemangiopericytomas Open
Even though CNS Hemangiopericytoma is a rare disease entity, local and distant recurrences are a cause of concern and require evaluation of role of adjuvant therapy. Our study shows that complete excision followed by adjuvant therapy in th…
View article: Non-Invasive Measurement of Elasticity in Glioblastoma Multiforme Validates Decreased TMZ Sensitivity in Astrocyte Co-Culture
Non-Invasive Measurement of Elasticity in Glioblastoma Multiforme Validates Decreased TMZ Sensitivity in Astrocyte Co-Culture Open
Goal: In this research, we investigated the changes in elasticity of in vitro glioblastoma multiforme (GBM) spheroids when treated with the gold standard chemotherapy for GBM, Temozolomide (TMZ). Additionally, we aimed to use this alternat…
View article: Acoustic Radiation Force Optical Coherence Elastography of the Crystalline Lens: Safety
Acoustic Radiation Force Optical Coherence Elastography of the Crystalline Lens: Safety Open
This work assessed the safety standards for acoustic radiation force to be used in human lens elastography according to the FDA safety limits.
View article: Generative Models Beyond GANs: Innovations in Image and Text Synthesis
Generative Models Beyond GANs: Innovations in Image and Text Synthesis Open
An evolution within generative models has taken place, going beyond Generative Adversarial Networks (GANs) into different structured approaches for both image and text generation. With the rise of advanced non-GAN-based generative models, …
View article: Dual optical elastography detects TGF-β-induced alterations in the biomechanical properties of skin scaffolds
Dual optical elastography detects TGF-β-induced alterations in the biomechanical properties of skin scaffolds Open
These findings offer valuable insights into -induced biomechanical alterations in bio-engineered skin scaffolds, highlighting the potential of OCE and Brillouin microscopy in the development of targeted therapies in conditions involvin…
View article: Dolutegravir induces FOLR1 expression during brain organoid development
Dolutegravir induces FOLR1 expression during brain organoid development Open
During the first month of pregnancy, the brain and spinal cord are formed through a process called neurulation. However, this process can be altered by low serum levels of folic acid, environmental factors, or genetic predispositions. In 2…
View article: Tunable Macroscopic Alignment of Self-Assembling Peptide Nanofibers
Tunable Macroscopic Alignment of Self-Assembling Peptide Nanofibers Open
Progress in the design and synthesis of nanostructured self-assembling systems has facilitated the realization of numerous nanoscale geometries, including fibers, ribbons, and sheets. A key challenge has been achieving control across multi…
View article: Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the <i>Mthfd1l</i> murine mutant
Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the <i>Mthfd1l</i> murine mutant Open
Neurulation is a highly synchronized biomechanical process leading to the formation of the brain and spinal cord, and its failure leads to neural tube defects (NTDs). Although we are rapidly learning the genetic mechanisms underlying NTDs,…
View article: Whole embryo biomechanics with reverberant optical coherence elastography
Whole embryo biomechanics with reverberant optical coherence elastography Open
Many morphogenesis processes during embryo development are fundamentally biomechanical processes, and disruption of these events can lead to debilitating congenital abnormalities. Imaging the biomechanical properties of embryos could provi…
View article: Tunable Macroscopic Alignment of Self-Assembling Peptide Nanofibers
Tunable Macroscopic Alignment of Self-Assembling Peptide Nanofibers Open
Fibrous proteins that comprise the extracellular matrix (ECM) guide cellular growth and tissue organization. A lack of synthetic strategies able to generate aligned, ECM-mimetic biomaterials has hampered bottom-up tissue engineering of ani…
View article: Optical coherence elastography measures the biomechanical properties of the ex vivo porcine cornea after LASIK
Optical coherence elastography measures the biomechanical properties of the ex vivo porcine cornea after LASIK Open
The results of this study suggest that LASIK may soften the cornea and that these changes are largely localized to the region where the surgery was performed.
View article: Effectiveness of Leukocyte- and Platelet-rich Fibrin in the Management of Medication-related Osteonecrosis of the Jaws – A Systematic Review
Effectiveness of Leukocyte- and Platelet-rich Fibrin in the Management of Medication-related Osteonecrosis of the Jaws – A Systematic Review Open
Background: Medication-related osteonecrosis of the jaw (MRONJ) is a rare, but significant adverse event primarily associated with the intake of antiresorptive and antiangiogenic medications. Although antiresorptive and antiangiogenic the-…
View article: Nanobomb optical coherence elastography in multilayered phantoms
Nanobomb optical coherence elastography in multilayered phantoms Open
Many tissues are composed of layered structures, and a better understanding of the changes in the layered tissue biomechanics can enable advanced guidance and monitoring of therapy. The advent of elastography using longitudinally propagati…
View article: Multifocal acoustic radiation force-based reverberant optical coherence elastography for evaluation of ocular globe biomechanical properties
Multifocal acoustic radiation force-based reverberant optical coherence elastography for evaluation of ocular globe biomechanical properties Open
The study demonstrated the effectiveness of RevOCE based on a non-invasive multifocal ARF for assessing the biomechanical properties of the whole eyeball. The findings indicate the potential to provide a comprehensive understanding of the …