Manne Munikumar
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View article: Naringin from Citrus maxima peel: a potential therapeutic agent for breast cancer via PKM2 inhibition
Naringin from Citrus maxima peel: a potential therapeutic agent for breast cancer via PKM2 inhibition Open
Introduction An extensive array of medicinal plants has undergone investigation, underscoring the imperative for the continued screening of natural inhibitors with the potential to target cancer metabolism. The current research endeavor wa…
View article: COVID-19 clinical outcomes and N-acetylcysteine (CoViNAC study): a GRADEcompliant meta-analysis of randomized controlled trials with molecular dockingand dynamics simulation studies with Mpro of SARS-CoV-2
COVID-19 clinical outcomes and N-acetylcysteine (CoViNAC study): a GRADEcompliant meta-analysis of randomized controlled trials with molecular dockingand dynamics simulation studies with Mpro of SARS-CoV-2 Open
N-acetylcysteine (NAC) has been proposed as an adjuvant therapy for COVID-19, but evidence from randomized controlled trials (RCTs) remains inconclusive. This systematic review and meta-analysis evaluated NAC's efficacy in improving mortal…
View article: Nutritional composition and in vitro bioaccessibility of minerals in the developed composite flours from Teff millet (Eragrostis tef) & guava leaves (Psidium guajava)
Nutritional composition and in vitro bioaccessibility of minerals in the developed composite flours from Teff millet (Eragrostis tef) & guava leaves (Psidium guajava) Open
In the present study, combination of Teff flour and powdered guava leaf was utilized to develop composite flour mixes. Effect of two different drying techniques of hot air oven and solar drying was assessed on the guava leaves for the comp…
View article: Multitargeted therapy in the convergence era: Systems pharmacology, smart delivery, and the rise of pan-biomarkers
Multitargeted therapy in the convergence era: Systems pharmacology, smart delivery, and the rise of pan-biomarkers Open
The landscape of therapeutic innovation is undergoing a profound transformation, driven by the convergence of systems pharmacology, smart drug-delivery platforms, and pan-biomarkers. This editorial explores the paradigm shift from organ-sp…
View article: Monitoring the progress and impact of a multicountry, interdisciplinary research project on childhood stunting: the UKRI GCRF Action Against Stunting Hub MEL protocol
Monitoring the progress and impact of a multicountry, interdisciplinary research project on childhood stunting: the UKRI GCRF Action Against Stunting Hub MEL protocol Open
Introduction Monitoring, Evaluation and Learning (MEL) is an integral part of research, programme and policy development and implementation. However, MEL methods used to monitor and evaluate interdisciplinary research projects are often in…
View article: Developing a data repository to support interdisciplinary research into childhood stunting: a UKRI GCRF Action Against Stunting Hub protocol paper
Developing a data repository to support interdisciplinary research into childhood stunting: a UKRI GCRF Action Against Stunting Hub protocol paper Open
Introduction As a topic of inquiry in its own right, data management for interdisciplinary research projects is in its infancy. Key issues include the inability of researchers to effectively query diverse data outputs and to identify poten…
View article: Epigenetic studies in children at risk of stunting and their parents in India, Indonesia and Senegal: a UKRI GCRF Action Against Stunting Hub protocol paper
Epigenetic studies in children at risk of stunting and their parents in India, Indonesia and Senegal: a UKRI GCRF Action Against Stunting Hub protocol paper Open
Introduction In 2020, an estimated 150 million children under the age of 5 years were stunted. Stunting results from early-life adversity and it is associated with significant physical and cognitive deficit, lifelong socioeconomic disadvan…
View article: Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines
Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines Open
Nitrogen-based heterocycles substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e, & 14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, and HCT116 cancer cell lines.
View article: Covid-19 Clinical Outcomes and N-Acetylcysteine (Covinac Study): A Grade Compliant Meta-Analysis of Randomized Controlled Trials, Molecular Docking, and Dynamics Simulations with Mpro of Sars-Cov-2
Covid-19 Clinical Outcomes and N-Acetylcysteine (Covinac Study): A Grade Compliant Meta-Analysis of Randomized Controlled Trials, Molecular Docking, and Dynamics Simulations with Mpro of Sars-Cov-2 Open
View article: Comprehensive structural and functional analysis of hVEGFR1: Insights into phosphorylation, molecular interactions, and potential inhibitors through docking and dynamics simulations
Comprehensive structural and functional analysis of hVEGFR1: Insights into phosphorylation, molecular interactions, and potential inhibitors through docking and dynamics simulations Open
Vascular Endothelial Growth Factor Receptor 1 (VEGFR1), is an enzyme with tyrosine kinase activity that plays a pivotal role in angiogenesis, the process of new blood vessel formation. This receptor is of significant clinical importance as…
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Contents list Open
View article: AI-Based Homology Modelling of Fatty Acid Transport Protein 1 Using AlphaFold: Structural Elucidation and Molecular Dynamics Exploration
AI-Based Homology Modelling of Fatty Acid Transport Protein 1 Using AlphaFold: Structural Elucidation and Molecular Dynamics Exploration Open
Fatty acid transport protein 1 (FATP1) is an integral transmembrane protein that is involved in facilitating the translocation of long-chain fatty acids (LCFA) across the plasma membrane, thereby orchestrating the importation of LCFA into …
View article: Seroprevalence of IgG and IgM Antibodies against SARS-CoV-2 Infection in Inhabitants of Itanagar Capital Region, Arunachal Pradesh, India
Seroprevalence of IgG and IgM Antibodies against SARS-CoV-2 Infection in Inhabitants of Itanagar Capital Region, Arunachal Pradesh, India Open
Objective:The assessment of novel coronavirus disease 2019 (COVID-19) antibodies is essential to understand the transmission dynamics of contagious disease. The proportion of the population who developed antibodies against the COVID…
View article: Childhood abuse and anxiety, depression – An interprofessional approach to optimize knowledge and awareness among young adult health professions students of Arunachal Pradesh, India
Childhood abuse and anxiety, depression – An interprofessional approach to optimize knowledge and awareness among young adult health professions students of Arunachal Pradesh, India Open
The interprofessional interactive sessions exhibited significant improvement in the knowledge and awareness in terms of child abuse and policies in all domains. Utmost need and necessity of including implementation of interprofessional int…
View article: Preliminary hypothetical assessment and in silico molecular docking of statin to VEGFR2 and VEGFR3 protein complex associated with angiogenesis and lymphangiogenesis in diabetic wounds
Preliminary hypothetical assessment and in silico molecular docking of statin to VEGFR2 and VEGFR3 protein complex associated with angiogenesis and lymphangiogenesis in diabetic wounds Open
In silico analysis of phytochemical compounds for optimizing the inhibitors of HMG CoA reductaseJ. Mercy Jasmine and R. Vanaja
View article: 3-deazaadenosine: A promising novel p38γ antagonist with potential as a breast cancer therapeutic agent
3-deazaadenosine: A promising novel p38γ antagonist with potential as a breast cancer therapeutic agent Open
Human p38γ protein kinase, or MAPK12, is a crucial signaling protein that is important in channelizing membrane signals to the nucleus in the MAPK cascade pathway, associated with breast and colorectal cancer, besides other forms of malign…
View article: Phenolic, nutritional and molecular interaction study among different millet varieties
Phenolic, nutritional and molecular interaction study among different millet varieties Open
View article: Assessment of Antioxidant, Immunomodulatory Activity of Oxidised Epigallocatechin-3-Gallate (Green Tea Polyphenol) and Its Action on the Main Protease of SARS-CoV-2—An In Vitro and In Silico Approach
Assessment of Antioxidant, Immunomodulatory Activity of Oxidised Epigallocatechin-3-Gallate (Green Tea Polyphenol) and Its Action on the Main Protease of SARS-CoV-2—An In Vitro and In Silico Approach Open
Owing to the instability of Epigallocatechin Gallate (EGCG), it may undergo auto-oxidation and form oxidised products or dimers. In the present study, we aimed to evaluate the therapeutic effects, including antioxidation and immunomodulato…
View article: COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials
COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials Open
A total of 6 RCTs with 551 COVID-19 patients were included. The overall collective evidence pooling all the outcomes across all RCTs indicated the beneficial use of vitamin D intervention in COVID-19 (relative risk, RR = 0.60, 95% CI 0.40 …
View article: D-dimer, disease severity, and deaths (3D-study) in patients with COVID-19: a systematic review and meta-analysis of 100 studies
D-dimer, disease severity, and deaths (3D-study) in patients with COVID-19: a systematic review and meta-analysis of 100 studies Open
Hypercoagulability and the need for prioritizing coagulation markers for prognostic abilities have been highlighted in COVID-19. We aimed to quantify the associations of D-dimer with disease progression in patients with COVID-19. This syst…
View article: Protective effects of a small molecule inhibitor ligand against hyperphosphorylated tau-induced mitochondrial and synaptic toxicities in Alzheimer disease
Protective effects of a small molecule inhibitor ligand against hyperphosphorylated tau-induced mitochondrial and synaptic toxicities in Alzheimer disease Open
The purpose of our study is to understand the protective effects of small molecule ligands for phosphorylated tau (p-tau) in Alzheimer’s disease (AD) progression. Many reports show evidence that phosphorylated tau is reported to be an impo…
View article: In silico evaluation of the compounds of the ayurvedic drug, AYUSH-64, for the action against the SARS-CoV-2 main protease
In silico evaluation of the compounds of the ayurvedic drug, AYUSH-64, for the action against the SARS-CoV-2 main protease Open
The results provide lead that, the presence of Mpro- Akuammicine N-Oxide with highest Mpro binding energy along with other 34 chemical compounds having similar activity as part of AYUSH-64 make it a suitable candidate…
View article: Cordifolioside: potent inhibitor against Mpro of SARS-CoV-2 and immunomodulatory through human TGF-β and TNF-α
Cordifolioside: potent inhibitor against Mpro of SARS-CoV-2 and immunomodulatory through human TGF-β and TNF-α Open
View article: Remdesivir (GS-5734) as a therapeutic option of 2019-nCOV main protease – <i>in silico</i> approach
Remdesivir (GS-5734) as a therapeutic option of 2019-nCOV main protease – <i>in silico</i> approach Open
2019 - Novel Coronavirus (2019-nCOV), enclosed large genome positive-sense RNA virus characterized by crown-like spikes that protrude from their surface, and have a distinctive replication strategy. The 2019-nCOV belongs to the Coronavirid…
View article: D-Dimer, Disease Severity, and Deaths (3D-Study) in Patients with COVID-19: A Systematic Review and Meta-Analysis
D-Dimer, Disease Severity, and Deaths (3D-Study) in Patients with COVID-19: A Systematic Review and Meta-Analysis Open
View article: Discovery of potential lumazine synthase antagonists for pathogens involved in bacterial meningitis: In silico study
Discovery of potential lumazine synthase antagonists for pathogens involved in bacterial meningitis: In silico study Open
Bacterial meningitis, an infection of the membranes (meninges) and cerebrospinal fluid (CSF) surrounding the brain and spinal cord, is a major cause of death and disability worldwide. Streptococcus pneumonia, Neisseria meningitidis, Haemop…
View article: α-lipoic acid inhibits oxidative stress in testis and attenuates testicular toxicity in rats exposed to carbimazole during embryonic period
α-lipoic acid inhibits oxidative stress in testis and attenuates testicular toxicity in rats exposed to carbimazole during embryonic period Open
View article: A meta-analysis of the association of serum ischaemia-modified albumin levels with human hypothyroidism and hyperthyroidism
A meta-analysis of the association of serum ischaemia-modified albumin levels with human hypothyroidism and hyperthyroidism Open
Serum levels of ischaemia-modified albumin (IMA) have been studied as a novel and simple measure of oxidative stress (OXS) in different thyroid pathologies. However, results of available studies in the literature were not consistent. This …
View article: 197 Combination of e-pharmacophore modeling, multiple docking strategies and molecular dynamic simulations to discover of novel antagonists of BACE1
197 Combination of e-pharmacophore modeling, multiple docking strategies and molecular dynamic simulations to discover of novel antagonists of BACE1 Open