Mannix J. Burns
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View article: Manipulating mitochondrial electron flow enhances tumor immunogenicity
Manipulating mitochondrial electron flow enhances tumor immunogenicity Open
Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow, remains unclear. In this work, we report that …
View article: BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4
BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4 Open
Significance Macrophages regulate many aspects of the innate immune response and the activation of adaptive immunity following exposure to microbial ligands. However, macrophages can also contribute to inflammation underlying diseases such…
View article: Comparison of Nodule Endophyte Composition, Diversity, and Gene Content Between <i>Medicago truncatula</i> Genotypes
Comparison of Nodule Endophyte Composition, Diversity, and Gene Content Between <i>Medicago truncatula</i> Genotypes Open
Leguminous plants form symbiotic relationships with rhizobia. These nitrogen-fixing bacteria live in specialized root organs called nodules. Although rhizobia form the most notable host relationship within root nodules, other bacterial end…
View article: Data integration of bulk and single-cell transcriptomics from cerebral organoids and post-mortem brains to identify cell types and cell type specific driver genes in autism
Data integration of bulk and single-cell transcriptomics from cerebral organoids and post-mortem brains to identify cell types and cell type specific driver genes in autism Open
Human-derived cerebral organoids demonstrate great promise for identifying cell types and cell type specific molecular processes perturbed by genetic variants associated with neuropsychiatric and neurodevelopmental disorders, which are not…
View article: Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids
Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids Open
Neuropsychiatric and neurodevelopmental disorders have been particularly challenging to study using animal models, and recently, human-derived cerebral organoids demonstrate great promise for discovering molecular processes that are import…
View article: Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases
Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases Open
Cardiovascular diseases are the leading cause of death worldwide, and as rates continue to increase, discovering mechanisms and therapeutic targets become increasingly important. An underlying cause of most cardiovascular diseases is belie…