Manoela Manova
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View article: Antidiabetic Medicines Utilisation During Pre-Pandemic, Pandemic and Post-Pandemic Period of COVID-19—Data for Bulgarian Population
Antidiabetic Medicines Utilisation During Pre-Pandemic, Pandemic and Post-Pandemic Period of COVID-19—Data for Bulgarian Population Open
Background: Type 2 diabetes is a chronic disease with high global prevalence and significant social and economic burden. The pandemic affected patients’ diagnostics and medicines dispensing. Diabetes was among the most-affected conditions …
View article: Real-world effectiveness of dabrafenib and trametinib in patients with BRAF-positive melanoma treated in routine Bulgarian clinical practice
Real-world effectiveness of dabrafenib and trametinib in patients with BRAF-positive melanoma treated in routine Bulgarian clinical practice Open
Malignant melanoma is among the leading forms of cancer on a global scale, accounting for 1 in 5 skin cancers. Over the past decades, the treatment of melanoma has significantly improved following the development of therapies such as MAPK …
View article: Transferability of new methods for health technology assessment in the field of diabetes between early and late adopters’ countries
Transferability of new methods for health technology assessment in the field of diabetes between early and late adopters’ countries Open
This study aimed to investigate the transferability of novel artificial intelligence (AI) methods for prediction modelling of diabetes based on real-world data (RWD) between early and late adopters of emerging health technologies from the …
View article: Recommendations for patient involvement in health technology assessment in Central and Eastern European countries
Recommendations for patient involvement in health technology assessment in Central and Eastern European countries Open
Introduction Meaningful patient involvement in health technology assessment (HTA) is essential in ensuring that the interests of the affected patient population, their families, and the general public are accurately reflected in coverage a…
View article: Recommendations to overcome barriers to the use of artificial intelligence-driven evidence in health technology assessment
Recommendations to overcome barriers to the use of artificial intelligence-driven evidence in health technology assessment Open
Background Artificial intelligence (AI) has attracted much attention because of its enormous potential in healthcare, but uptake has been slow. There are substantial barriers that challenge health technology assessment (HTA) professionals …
View article: Adequate effectiveness of ribociclib plus letrozole or fulvestrant in patients with advanced or metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer treated in routine Bulgarian clinical practice
Adequate effectiveness of ribociclib plus letrozole or fulvestrant in patients with advanced or metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer treated in routine Bulgarian clinical practice Open
Randomized controlled trials (RCTs) are typically conducted in highly selected patient populations to ideally demonstrate unconfounded clinical efficacy of a drug. In the real world, there may be confounding factors, such as comorbidities …
View article: Impact of generics competition on prices and utilization of antiepileptic medicines in Bulgaria
Impact of generics competition on prices and utilization of antiepileptic medicines in Bulgaria Open
Generic competition and drug prices in the Malaysian off-patent pharmaceutical marketOmotayo Fatokun, Mohamed Izham Mohamed Ibrahim, Mohamed Azmi Hassali
View article: Comparison of Cardiovascular Medicines Prices in Four European Countries
Comparison of Cardiovascular Medicines Prices in Four European Countries Open
The aim of the current study was to compare pricing methodologies at the manufacturer, wholesale, and retail levels, and to estimate the price differences of AT1-receptor blockers (sartans), Angiotensin-converting enzyme (ACE)-inhibitors, …
View article: Life expectancy and survival analysis of patients with diabetes compared to the non diabetic population in Bulgaria
Life expectancy and survival analysis of patients with diabetes compared to the non diabetic population in Bulgaria Open
Patients with type 2 DM have a longer life-expectancy than patients with type-1 DM and overall Diabetics life expectancy equals that of the non-diabetic population, which could suggest improved disease control and its associated complicati…
View article: Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria
Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria Open
Background This study investigates the cost-effectiveness of insulin degludec (degludec) versus biosimilar insulin glargine U100 (glargine U100) in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in Bulgaria.Methods A simpl…
View article: Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria
Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria Open
Background This study investigates the cost-effectiveness of insulin degludec (degludec) versus biosimilar insulin glargine U100 (glargine U100) in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in Bulgaria.Methods A simpl…
View article: Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria
Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria Open
Background This study investigates the cost-effectiveness of insulin degludec (degludec) versus biosimilar insulin glargine U100 (glargine U100) in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in Bulgaria.Methods A simpl…
View article: Reimbursement Legislations and Decision Making for Orphan Drugs in Central and Eastern European Countries
Reimbursement Legislations and Decision Making for Orphan Drugs in Central and Eastern European Countries Open
BACKGROUND: Reimbursement policies influence access of patients to orphan drugs in the European countries. OBJECTIVES: To provide a comprehensive description of orphan drug reimbursement policies and to assess reimbursement decision-making…
View article: Incretins and SGLT-2i Therapy of Type 2 Diabetes – Real Life Study of Their Therapeutic and Economic Effects
Incretins and SGLT-2i Therapy of Type 2 Diabetes – Real Life Study of Their Therapeutic and Economic Effects Open
Incretins [dipeptidyl peptidase-4 inhibitors (DPP-4i) and glucagon-like peptide 1 receptor agonists (GLP-1 RA)] and sodium-glucose linked transporter-2 inhibitors (SGLT-2i) therapy steadily decreases the HbA1c level, and risk of developing…
View article: Micro and macro analysis on the burden of COPD hospitalizations on the Bulgarian healthcare system
Micro and macro analysis on the burden of COPD hospitalizations on the Bulgarian healthcare system Open
The aim of this study was to investigate the economic burden of Chronic Obstructive Pulmonary Disease (COPD)-related hospitalizations on a macro and micro level. Macro analysis was performed on the rate of DDD utilisation of COPD medicines…
View article: Improved quality of diabetes control reduces complication costs in Bulgaria
Improved quality of diabetes control reduces complication costs in Bulgaria Open
The study investigates the quality of diabetes control and its economic implications in Bulgaria for the years 2012–2016. It is a retrospective study of the national diabetes register. Patients were categorized according to type of diabete…
View article: Comparative Price Analysis of Biological Products for Treatment of Rheumatoid Arthritis
Comparative Price Analysis of Biological Products for Treatment of Rheumatoid Arthritis Open
Biological products for treatment of rheumatoid arthritis usually are cost effective for healthcare systems in Europe, but they are huge financial burden due to the high number of patients and the significant budget impact. The expected sa…
View article: Comparative Analysis of Legislative Requirements About Patients' Access to Biotechnological Drugs for Rare Diseases in Central and Eastern European Countries
Comparative Analysis of Legislative Requirements About Patients' Access to Biotechnological Drugs for Rare Diseases in Central and Eastern European Countries Open
Objectives: The aim of the study was to compare the access of patients with rare diseases (RDs) to biotechnological drugs in several Central and Eastern European countries (CEECs). We focused on the legislative pricing and reimbursement re…
View article: An Overview of the Reimbursement Decision-Making Processes in Bulgaria As a Reference Country for the Middle-Income European Countries
An Overview of the Reimbursement Decision-Making Processes in Bulgaria As a Reference Country for the Middle-Income European Countries Open
Optimization of the procedure for issuing reimbursement status for innovative MPs is needed, such as improvements in the process of conducting HTA reports and their appraisal, incorporation of adequate systems for following the effectivene…
View article: Intervention Packages to Reduce the Impact of HIV and HCV Infections Among People Who Inject Drugs in Eastern Europe and Central Asia: A Modeling and Cost-effectiveness Study
Intervention Packages to Reduce the Impact of HIV and HCV Infections Among People Who Inject Drugs in Eastern Europe and Central Asia: A Modeling and Cost-effectiveness Study Open
Background We evaluated the effectiveness and cost-effectiveness of interventions targeting hepatitis C virus (HCV) and HIV infections among people who inject drugs (PWID) in Eastern Europe/Central Asia. We specifically considered the need…
View article: Polycystic ovary syndrome impact on women's quality of life: pilot study
Polycystic ovary syndrome impact on women's quality of life: pilot study Open
Purpose: The aim of this study is to assess the impact of Polycystic Ovary Syndrome (PCOS) on Bulgarian patients' QoL through a Polycystic Ovary Syndrome Questionnaire (PCOSQ).Methods: A pilot survey was conducted in a sample of individual…
View article: Statins utilization and price variations-comparison between Ukraine and Bulgaria
Statins utilization and price variations-comparison between Ukraine and Bulgaria Open
Introduction: High prevalence rate of CVD and high rate of CVD deaths attributed to high cholesterol leads to increased statins utilization. The aim of this study is to analyse the difference in prices between generic and innovator and uti…