Manoj K. Pandey
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View article: More work for ASHAs? Exploring the role of whatsapp messaging and community health work in urban slum areas of Varanasi, India
More work for ASHAs? Exploring the role of whatsapp messaging and community health work in urban slum areas of Varanasi, India Open
India’s community health workers (CHWs) have taken on an onerous set of responsibilities for the welfare of their clients across a variety of health domains, including providing modern contraception for family planning, promoting childhood…
View article: Central Roles of Glucosylceramide in Driving Cancer Pathogenesis
Central Roles of Glucosylceramide in Driving Cancer Pathogenesis Open
Glucosylceramide (GlcCer), a central glycosphingolipid derived from ceramide, is increasingly recognized as a bioactive lipid that intersects with key metabolic, inflammatory, and oncogenic pathways. While its dysregulation has long been a…
View article: Impact of Macro-Environmental Factors on BusinessSustainability in The Leather Industry of Kanpur and Unnao, Uttar Pradesh
Impact of Macro-Environmental Factors on BusinessSustainability in The Leather Industry of Kanpur and Unnao, Uttar Pradesh Open
This study examines the influence of macro-environmental factors on business sustainability in the leather industry, focusing on firms in Kanpur and Unnao, Uttar Pradesh, India. A quantitative approach was employed, utilizing a structure…
View article: Emerging role of complement system in the induction of neuroinflammation in adenylosuccinate lyase deficiency disorder
Emerging role of complement system in the induction of neuroinflammation in adenylosuccinate lyase deficiency disorder Open
Adenylosuccinate lyase deficiency disorder (ADSLDD) is an ultra-rare autosomal recessive metabolic condition that leads to severe neurological impairment, with an estimated global prevalence of approximately 0.00125 cases per 100,000 indiv…
View article: A new member at the table: Granzyme K as a lymphocyte‐born complement initiator
A new member at the table: Granzyme K as a lymphocyte‐born complement initiator Open
View article: Molecular Diplomacy of Lipids in the War of Immunity: Bridging Rare and Common Disease Mechanisms
Molecular Diplomacy of Lipids in the War of Immunity: Bridging Rare and Common Disease Mechanisms Open
The panorama of biomedical and translational research is experiencing a profound conceptual evolution, one that calls for a reassessment of traditional binaries, such as active versus inactive, genetic versus epigenetic, and structural ver…
View article: Factors Affecting Impact Investment among Generation Z: The Moderating Role of Behavioral Biases
Factors Affecting Impact Investment among Generation Z: The Moderating Role of Behavioral Biases Open
This study explores the determinants that affect impact investment behavior, with a particular emphasis on the moderating influence of behavioral biases. The inquiry examines principal factors influencing impact investment, encompassing en…
View article: Editorial: Deciphering the role of signature genes in cancer prognosis and therapy resistance
Editorial: Deciphering the role of signature genes in cancer prognosis and therapy resistance Open
View article: A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression
A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression Open
Introduction Heterozygous deletions predicting haploinsufficiency for the Cysteine Rich Motor Neuron 1 ( CRIM1 ) gene have been identified in two families with macrophthalmia, colobomatous, with microcornea (MACOM), an autosomal dominant t…
View article: Influence of Soil Nutrients and Agronomic Practices on Phytochemical Composition and Antioxidant Potential of Bitter Gourd (<i>Momordica charantia</i>)
Influence of Soil Nutrients and Agronomic Practices on Phytochemical Composition and Antioxidant Potential of Bitter Gourd (<i>Momordica charantia</i>) Open
Bitter gourd (Momordica charantia) is a climber vegetable known for its diverse phytochemicals and potent antioxidant properties. These characteristics are strongly influenced by environmental factors, particularly soil nutrient compositio…
View article: Complement System and Adhesion Molecule Skirmishes in Fabry Disease: Insights into Pathogenesis and Disease Mechanisms
Complement System and Adhesion Molecule Skirmishes in Fabry Disease: Insights into Pathogenesis and Disease Mechanisms Open
Fabry disease is a rare X-linked lysosomal storage disorder caused by mutations in the galactosidase alpha (GLA) gene, resulting in the accumulation of globotriaosylceramide (Gb3) and its deacetylated form, globotriaosylsphingosine (Lyso-G…
View article: Immunological harmony: the dynamic influence of cellular and humoral immunity on pregnancy success
Immunological harmony: the dynamic influence of cellular and humoral immunity on pregnancy success Open
This study is a crucial step in understanding the dynamics of the maternal immune response directed at paternal human leukocyte antigen (HLA) molecules. HLA molecules are proteins on cell surfaces that play a critical role in immune system…
View article: The Quality of Life among Tribal Communities Living in Western Ghats: An Exploratory Research
The Quality of Life among Tribal Communities Living in Western Ghats: An Exploratory Research Open
The Western Ghats (WG), also called Sahyadri, are a mountain range that covers 140,000 square kilometres and extends parallel to the western coast of the Indian Peninsula. The WG have been home to over fifty distinct tribes. The tribal com…
View article: Uncovering the Lipid Web: Discovering the Multifaceted Roles of Lipids in Human Diseases and Therapeutic Opportunities
Uncovering the Lipid Web: Discovering the Multifaceted Roles of Lipids in Human Diseases and Therapeutic Opportunities Open
Lipids, characterized by their hydrophobic nature, encompass a wide range of molecules with distinct properties and functions [...]
View article: Complement Turning Violent in Ultra-Rare Genetic Disorder
Complement Turning Violent in Ultra-Rare Genetic Disorder Open
Sandhoff disease (SD) is an ultra-rare lysosomal storage disorder (LSD), which affects ~ 1/1000, 000 live birth. SD is caused by genetic deficiency of beta (β) Hexosaminidase and resulting excess central nervous system (CNS) synthesis of G…
View article: Exploring Pro-Inflammatory Immunological Mediators: Unraveling the Mechanisms of Neuroinflammation in Lysosomal Storage Diseases
Exploring Pro-Inflammatory Immunological Mediators: Unraveling the Mechanisms of Neuroinflammation in Lysosomal Storage Diseases Open
Lysosomal storage diseases are a group of rare and ultra-rare genetic disorders caused by defects in specific genes that result in the accumulation of toxic substances in the lysosome. This excess accumulation of such cellular materials st…
View article: Targeting the Complement–Sphingolipid System in COVID-19 and Gaucher Diseases: Evidence for a New Treatment Strategy
Targeting the Complement–Sphingolipid System in COVID-19 and Gaucher Diseases: Evidence for a New Treatment Strategy Open
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced disease (COVID-19) and Gaucher disease (GD) exhibit upregulation of complement 5a (C5a) and its C5aR1 receptor, and excess synthesis of glycosphingolipids that lead to in…
View article: EFFECT OF DIFFERENT CONCENTRATIONS OF AUXIN AND CYTOKININ ON CALLUS INDUCTION AND DEVELOPMENT OF PEPINO (Solanum muricatum Ait.) cv. VALENTIA
EFFECT OF DIFFERENT CONCENTRATIONS OF AUXIN AND CYTOKININ ON CALLUS INDUCTION AND DEVELOPMENT OF PEPINO (Solanum muricatum Ait.) cv. VALENTIA Open
\n\n\nPepino shoot tips, leaves and nodal segments were used as the explants for initiating in-vitro culture. The explants were cut into suitable segments and thoroughly sterilized with different sterilization agents namely Mercuric Chlori…
View article: Pulmonary tuberculosis: An observational study to compare radiographic abnormalities with reference to smear microscopy status
Pulmonary tuberculosis: An observational study to compare radiographic abnormalities with reference to smear microscopy status Open
Background: Interpretation of Chest X Ray (CXR) in relation to sputum smear microscopy can be useful in early diagnosis of pulmonary TB. The study aimed to compare the CXR findings in pulmonary TB cases with positive sputum microscopy and …
View article: Pre‐existing humoral immune comebacks control the development of the severe form of coronavirus disease 2019 in Gaucher patients
Pre‐existing humoral immune comebacks control the development of the severe form of coronavirus disease 2019 in Gaucher patients Open
Coronavirus disease 2019 (COVID‐19) and the Gaucher disease (GD) exhibit lot of resemblances in induction of innate and adaptive immune inflammation that include the immune cells activation and the massive generation of pro‐inflammatory cy…
View article: The Role of Alpha-Synuclein Autoantibodies in the Induction of Brain Inflammation and Neurodegeneration in Aged Humans
The Role of Alpha-Synuclein Autoantibodies in the Induction of Brain Inflammation and Neurodegeneration in Aged Humans Open
OPINION article Front. Aging Neurosci., 26 May 2022Sec. Cellular and Molecular Mechanisms of Brain-aging https://doi.org/10.3389/fnagi.2022.902191
View article: An Ecological Study on Some Phisico Chemical Parameters of Dah Puraina Lake of Saran
An Ecological Study on Some Phisico Chemical Parameters of Dah Puraina Lake of Saran Open
During the first and second year of study the lowest air temperature was recorded in the month of January at all the sites . The air temperature showed positive and significant correlation with water temperature at all the sites. Chakrabor…
View article: Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson’s Disease
Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson’s Disease Open
Parkinson’s disease (PD) is the second-most common neurodegenerative disease in the world, affecting up to 10 million people. This disease mainly happens due to the loss of dopaminergic neurons accountable for memory and motor function. Pa…
View article: Abstract- Poster
Abstract- Poster Open
INTRODUCTION: Formal Thought Disorder (FTD) is regarded as a cardinal symptom of Schizophrenia (Goldberg and Werberger; 2000) and is characterized by aberrant speech pattern and inappropriate word use. The causal and openings of this pheno…
View article: C-X-C Motif Chemokine Ligand 9 and Its CXCR3 Receptor Are the Salt and Pepper for T Cells Trafficking in a Mouse Model of Gaucher Disease
C-X-C Motif Chemokine Ligand 9 and Its CXCR3 Receptor Are the Salt and Pepper for T Cells Trafficking in a Mouse Model of Gaucher Disease Open
Gaucher disease is a lysosomal storage disease, which happens due to mutations in GBA1/Gba1 that encodes the enzyme termed as lysosomal acid β-glucosidase. The major function of this enzyme is to catalyze glucosylceramide (GC) into glucose…
View article: Role of Molecular Markers in Crop Breeding: A Review
Role of Molecular Markers in Crop Breeding: A Review Open
Molecular markers are effective tools used to ‘flag’ the location of a specific gene or the inheritance of a definite trait. Markers are unique DNA fragments that can be identified inside the entire genome. The development of molecular mar…
View article: Original Research Article_Study of Inter-Relationship Between Perceived Workplace Discrimination, Job Stress, Mental Well-Being, And Job Performance of Teachers
Original Research Article_Study of Inter-Relationship Between Perceived Workplace Discrimination, Job Stress, Mental Well-Being, And Job Performance of Teachers Open
Background: This study was planned to investigate the consequences of perceived workplace discrimination on job stress, mental well-being, and teachers' job performance in higher education.A conceptual model was proposed to illustrate the …
View article: Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease
Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease Open
Parkinson's disease (PD) is a movement disorder attributed to the loss of dopaminergic (DA) neurons mainly in the substantia nigra pars compacta. Motor symptoms include resting tremor, rigidity, and bradykinesias, while non-motor symptoms …
View article: Frontmatter
Frontmatter Open
View article: Predictors of Mortality in Patients of COVID-19 Pneumonia in Intensive Care Unit: An Observational Study in a Tertiary Care Hospital, Lucknow, India
Predictors of Mortality in Patients of COVID-19 Pneumonia in Intensive Care Unit: An Observational Study in a Tertiary Care Hospital, Lucknow, India Open
Introduction: Coronavirus Disease-2019 (COVID-19) is caused by the Severe Acute Respiratory Coronavirus-2 (SARS-CoV-2) which is an enveloped positive-sense single-stranded RNA virus. Initial steps of the infection involve binding of the sp…