Manoj K. Mishra
YOU?
Author Swipe
View article: Estimation of Atmospheric Haze Variability and Seasonal Variation of Convective Boundary Layer (CBL) Height Over Kasei Valles of Mars
Estimation of Atmospheric Haze Variability and Seasonal Variation of Convective Boundary Layer (CBL) Height Over Kasei Valles of Mars Open
Images from Mars Color Camera (MCC) onboard India’s first Mars Orbiter Mission (MOM) during Martian years 33 and 34 provides the evidence of dense haze, water ice cloud, and all scale dust storms over Kasei Valles. The clouds and haze cont…
View article: A Distinct Hibiscus sabdariffa Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology
A Distinct Hibiscus sabdariffa Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology Open
Iron deposition in the brain begins early in multiple sclerosis (MS) and continues unabated. Ferrous iron is toxic to neurons, yet the therapies used in MS do not counter iron neurotoxicity. Extracts of Hibiscus sabdariffa (HS) are used in…
View article: Harnessing the Benefits of Neuroinflammation: Generation of Macrophages/Microglia with Prominent Remyelinating Properties
Harnessing the Benefits of Neuroinflammation: Generation of Macrophages/Microglia with Prominent Remyelinating Properties Open
Excessive inflammation within the CNS is injurious, but an immune response is also required for regeneration. Macrophages and microglia adopt different properties depending on their microenvironment, and exposure to IL4 and IL13 has been u…
View article: IDENTIFICATION OF PREFERRED SOURCES FOR THE SCHOLARLY COMMUNICATIONS OF THE INDIAN CORPORATE MEDICAL INSTITUTIONS USING BRADFORD’S LAW OF SCATTERING
IDENTIFICATION OF PREFERRED SOURCES FOR THE SCHOLARLY COMMUNICATIONS OF THE INDIAN CORPORATE MEDICAL INSTITUTIONS USING BRADFORD’S LAW OF SCATTERING Open
Introduction: Health science research focuses to generate new knowledge through new techniques, research design and organizational interventions to serve the whole community. The number of documents published during a stipulated time is me…
View article: COMPARISON OF TWO LOW DOSE REGIMENS OF SUBARACHNOID BLOCK ANESTHESIA FOR LOWER SEGMENT CAESARIAN SECTION
COMPARISON OF TWO LOW DOSE REGIMENS OF SUBARACHNOID BLOCK ANESTHESIA FOR LOWER SEGMENT CAESARIAN SECTION Open
Hypotension and bradycardia due to sympathetic blockade are two commonest complications of spinal anesthesia leading to maternal and neonatal morbidity and mortality. Aorto caval compression due to gravid uterus also contributes to the dev…
View article: Aging-Exacerbated Acute Axon and Myelin Injury Is Associated with Microglia-Derived Reactive Oxygen Species and Is Alleviated by the Generic Medication Indapamide
Aging-Exacerbated Acute Axon and Myelin Injury Is Associated with Microglia-Derived Reactive Oxygen Species and Is Alleviated by the Generic Medication Indapamide Open
Age is a critical risk factor for many neurologic conditions, including progressive multiple sclerosis. Yet the mechanisms underlying the relationship are unknown. Using lysolecithin-induced demyelinating injury to the mouse spinal cord, w…
View article: The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination
The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination Open
View article: Correction to: Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system
Correction to: Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system Open
View article: Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system Open
View article: Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis
Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis Open
Multiple sclerosis presents with profound changes in the network of molecules involved in maintaining central nervous system architecture, the extracellular matrix. The extracellular matrix components, particularly the chondroitin sulfate …
View article: Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic Open
View article: Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury
Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury Open
View article: Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic–ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia
Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic–ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia Open
View article: Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis
Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis Open
Significance Gestational bisphenol-A exposure increases susceptibility to autoimmunity in a mouse model of multiple sclerosis; the disease manifested in adult male, but not female, mice when a suboptimal insult was applied. Bisphenol-A may…
View article: Taste masking of drugs: an extended approach
Taste masking of drugs: an extended approach Open
Taste is an important factor in the development of dosage form.identity to a product .Taste is mainly a function of taste buds in the mouth important parameter in case of drugs administering orally and is a critical factor.Humans can disti…
View article: Accumulation and cellular localization of nanoparticles in an ex vivo model of acute lung injury
Accumulation and cellular localization of nanoparticles in an ex vivo model of acute lung injury Open
View article: Nanoparticle-mediated neuroprotection in a rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION)
Nanoparticle-mediated neuroprotection in a rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION) Open
View article: Surface functionality affects the biodistribution and microglia-targeting of intra-amniotically delivered dendrimers
Surface functionality affects the biodistribution and microglia-targeting of intra-amniotically delivered dendrimers Open
View article: Nanoscale effects in dendrimer-mediated targeting of neuroinflammation
Nanoscale effects in dendrimer-mediated targeting of neuroinflammation Open
View article: Regenerative Capacity of Macrophages for Remyelination
Regenerative Capacity of Macrophages for Remyelination Open
White matter injury, consisting of loss of axons, myelin, and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative m…
View article: Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy
Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy Open
Dendrimers selectively target the ischemic ON lesion after induction of both rNAION and pNAION. Systemic nanoparticle-linked therapeutics thus may provide a powerful, targeted and safe approach to NAION treatment by providing sustained and…
View article: Immunosenescence of microglia and macrophages: impact on the ageing central nervous system
Immunosenescence of microglia and macrophages: impact on the ageing central nervous system Open
Ageing of the central nervous system results in a loss of both grey and white matter, leading to cognitive decline. Additional injury to both the grey and white matter is documented in many neurological disorders with ageing, including Alz…
View article: Changes in CXCR3, CXCL9, CXCL10, CXCL11, TNF-α, IL-12p40 and IFN-γ mRNA expressions by EAC mice after anti-CXCL10 Ab treatment.
Changes in CXCR3, CXCL9, CXCL10, CXCL11, TNF-α, IL-12p40 and IFN-γ mRNA expressions by EAC mice after anti-CXCL10 Ab treatment. Open
At the experimental end point, total RNA was isolated from the immune cells of iliac lymph nodes, or urinary bladder of the mice.RT-PCR analysis of unaffected group control Ab [white bar], Anti-CXCL10 Ab [gray bar], EAC induced group EAC+ …
View article: Dendrimer-enabled transformation of Anaplasma phagocytophilum
Dendrimer-enabled transformation of Anaplasma phagocytophilum Open
View article: Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia/Macrophage in Ischemia/Reperfusion Mouse Retina
Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia/Macrophage in Ischemia/Reperfusion Mouse Retina Open
Intravitreal and systemic dendrimers target activated microglia and show qualitatively similar retinal biodistribution when administered by either route. Results provide proof-of-concept insights for developing dendrimer drug formulations …
View article: Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers
Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers Open
View article: Intracellular delivery of dendrimer triamcinolone acetonide conjugates into microglial and human retinal pigment epithelial cells
Intracellular delivery of dendrimer triamcinolone acetonide conjugates into microglial and human retinal pigment epithelial cells Open
View article: Stimulation of Monocytes, Macrophages, and Microglia by Amphotericin B and Macrophage Colony-Stimulating Factor Promotes Remyelination
Stimulation of Monocytes, Macrophages, and Microglia by Amphotericin B and Macrophage Colony-Stimulating Factor Promotes Remyelination Open
Approaches to stimulate remyelination may lead to recovery from demyelinating injuries and protect axons. One such strategy is the activation of immune cells with clinically used medications, since a properly directed inflammatory response…