Manoj Sivan
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View article: Digitally Assessed Long COVID Symptomatology Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential
Digitally Assessed Long COVID Symptomatology Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential Open
Background Postacute sequelae of SARS-CoV-2 infection, also known as long COVID (LC), is a complex and heterogenous condition affecting millions worldwide with a poorly understood underlying pathology. Although metabolic dysregulations hav…
View article: Normative data for the 10-min lean test in adults without orthostatic intolerance
Normative data for the 10-min lean test in adults without orthostatic intolerance Open
Background Orthostatic intolerance syndromes such as Orthostatic Hypotension (OH) and Postural Orthostatic Tachycardia Syndrome (PoTS) are common symptoms seen in post-infection conditions and other neurological conditions with autonomic d…
Health economic outcomes and national economic impacts associated with Long COVID in England and Scotland Open
Background Two million people in the UK suffer from Long COVID (LC), imposing substantial health economic impacts. This study aimed to: 1) assess longitudinal changes in health utility scores and economic costs of LC, and number of service…
Addressing Inequalities in Long Covid Healthcare: A Mixed‐Methods Study on Building Inclusive Services Open
Background Long Covid (LC) significantly impacts health, economic and social activities. Women, deprived, learning disability, homeless and some minority ethnic populations have high prevalence rates but low access to support, indicating h…
Shared neural signatures in Functional Neurological Disorder and Chronic Pain: a multimodal narrative review Open
Background Functional neurological disorder (FND) frequently co-exists with chronic pain (CP), notably nociceptive and nociplastic (primary) pain disorders. The considerable overlap implies shared underlying mechanisms because of their sim…
Large-scale psychometric assessment and validation of the Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) patient-reported outcome measure for Long COVID or Post-COVID syndrome Open
Background The C19-YRS was the first condition-specific scale for Long COVID/Post-COVID syndrome. Although the original C19-YRS evolved to the modified version (C19-YRSm) based on psychometric evidence, clinical content relevance and feedb…
View article: Normative data for the 10-min Lean Test in individuals without Orthostatic Intolerance
Normative data for the 10-min Lean Test in individuals without Orthostatic Intolerance Open
Background Orthostatic intolerance syndromes such as Orthostatic Hypotension (OH) and Postural Orthostatic Tachycardia Syndrome (PoTS) are common symptoms seen in post-infection conditions and other neurological conditions with autonomic d…
View article: Exploring the experiences of cognitive symptoms in Long COVID: a mixed-methods study in the UK
Exploring the experiences of cognitive symptoms in Long COVID: a mixed-methods study in the UK Open
Objective To explore the lived experiences and extent of cognitive symptoms in Long COVID (LC) in a UK-based sample. Design This study implemented a mixed-methods design. Eight focus groups were conducted to collect qualitative data, and t…
Health-Related Quality of Life in Long COVID: Mapping the Condition-Specific C19-YRSm Measure Onto the EQ-5D-5L Open
A simple, responsive, and robust mapping algorithm was developed to generate enable EQ-5D-3L health utilities from the C19-YRSm. This will facilitate economic evaluations of LC interventions, treatment, and management, as well as further h…
View article: Daily stress and worry are additional triggers of symptom fluctuations in individuals living with Long COVID: results from an intensive longitudinal cohort study
Daily stress and worry are additional triggers of symptom fluctuations in individuals living with Long COVID: results from an intensive longitudinal cohort study Open
Background Recent research has shown that exertion in physical, cognitive, social, and self-care activities triggers symptom severity in individuals with Long COVID. Purpose The current study aimed to investigate whether daily emotional ex…
A Personalised Pacing and Active Rest Rehabilitation Programme for Post-Exertional Symptom Exacerbation and Health Status in Long COVID (PACELOC): A Prospective Cohort Study Open
Background: Post-COVID-19 Syndrome or long COVID (LC) is a novel public health crisis and, when persistent (>2 years), is a long-term condition. Post-exertional symptom exacerbation (PESE) is a characteristic symptom of LC and can be impro…
Effect of a Personalised Pacing and Active Rest Rehabilitation Programme on Post-Exertional Symptom Exacerbation and Health Status in Long COVID (PACELOC). A Prospective Cohort Study Open
Background: Post-COVID Syndrome or long COVID (LC) is a novel public health crisis and, when persistent ( 2 years), is a long-term condition. Post-exertional Symptom Exacerbation (PESE) is a characteristic symptom of LC and can be improved…
How Long Is Long COVID? Evaluation of Long-Term Health Status in Individuals Discharged from a Specialist Community Long COVID Service Open
Background: Post COVID-19 syndrome or long COVID (LC) is a novel fluctuating condition with a protracted course in some patients. Specialist LC services have been operational in the UK since 2020 and deal with a high caseload of patients. …
Physical, cognitive, and social triggers of symptom fluctuations in people living with long COVID: an intensive longitudinal cohort study Open
National Institute for Health and Care Research.
How Long is Long COVID? Evaluation of Long-Term Health Status in Individuals Discharged from a Specialist Community Long COVID Service Open
Background: Post COVID-19 syndrome or Long Covid (LC) is a novel fluctuating condition with a protracted course in some patients. Specialist LC services have been operational in the UK since 2020 and deal with a high caseload of patients. …
Translation and cultural adaptation of the COVID-19 Yorkshire Rehabilitation Scale into German Open
Background Experts estimate that in up to 10% of the infected, SARS-CoV-2 would cause persistent symptoms, activity limitations and reduced quality of life. Referred to as long COVID, these conditions might, in the future, specifically imp…
New-Onset Chronic Musculoskeletal Pain Following COVID-19 Infection Fulfils the Fibromyalgia Clinical Syndrome Criteria: A Preliminary Study Open
New-onset chronic musculoskeletal (MSK) pain (>3 months duration) is a common symptom of post-COVID-19 syndrome (PCS). This study aimed to characterise new-onset chronic MSK pain in patients with PCS and its overlap with Fibromyalgia Syndr…
Health-related quality of life in Long COVID: Mapping the condition-specific C19-YRSm measure onto the EQ-5D-5L Open
Background Long Covid (LC) is a clinical syndrome of persistent, fluctuating symptoms subsequent to COVID-19 infection with a prevalence global estimate of many millions of cases. LC has significant detrimental effects on health-related qu…
New-onset chronic musculoskeletal pain following COVID-19 infection fulfil the Fibromyalgia clinical syndrome criteria Open
Background New-onset chronic musculoskeletal (MSK) pain (> 3 months duration) is one of the commonest persistent symptoms of Post-COVID syndrome (PCS). There is emerging evidence that the chronic MSK pain and associated symptoms in PCS hav…
Clinical Characterization of New-Onset Chronic Musculoskeletal Pain in Long COVID: A Cross-Sectional Study Open
New-onset chronic MSK pain in LC tends to be widespread, constant, and associated with weakness, reduced function, depression, anxiety, and reduced quality of life. There is associated central sensitization and proinflammatory state in the…
Identifying the needs of people with long COVID: a qualitative study in the UK Open
Objectives To identify the needs of people with long COVID (LC) in the UK. Design Qualitative study using the Framework Analysis to analyse focus group discussions. Participants 25 adults with LC aged 19–76 years including 17 men and 8 wom…
Psychometric analysis of the modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) in a prospective multicentre study Open
Background Long COVID (LC) is a novel multisystem clinical syndrome affecting millions of individuals worldwide. The modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) is a condition-specific patient-reported outcome measure desig…
Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review Open
Introduction: Long COVID (LC) is a global public health crisis affecting more than 70 million people. There is emerging evidence of different pathophysiological mechanisms driving the wide array of symptoms in LC. Understanding the relatio…
Long COVID Clinical Severity Types Based on Symptoms and Functional Disability: A Longitudinal Evaluation Open
Background: Long COVID (LC) is a multisystem clinical syndrome with functional disability and compromised overall health. Information on LC clinical severity types is emerging in cross-sectional studies. This study explored the pattern and…
Functional Seizures and Chronic Pain: A Narrative Review of common Pathomechanisms and Clinical Implications Open
Background Functional seizures (FS) manifest as episodic events, bearing superficial similarities to epileptic seizures and represent a major component of Functional Neurological Disorder (FND). FS frequently present with the co-morbidity …
Clinical characterization of new-onset chronic musculoskeletal pain in Long COVID: a cross-sectional study Open
Purpose New-onset chronic musculoskeletal (MSK) pain is one of the common persistent symptoms in Long COVID (LC). This study investigated its clinical characteristics, underlying mechanisms, and impact on function, psychological health, an…