Manolis A. Fousteris
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View article: New Esters of Ferrediol and Sideritriol in <i>Sideritis clandestina</i> subsp. <i>peloponnesiaca</i>: Characterization and Antiproliferative Activity
New Esters of Ferrediol and Sideritriol in <i>Sideritis clandestina</i> subsp. <i>peloponnesiaca</i>: Characterization and Antiproliferative Activity Open
17-Isovalerate esters of ferrediol and sideritriol (compounds 1 and 5) and 17-(2-methylbutyrate) ferrediol (compound 2), which have not been earlier described, were isolated along with five known ent-15-kaurene …
View article: Design, synthesis and biological evaluation of new 3,4-dihydroquinoxalin-2(1H)-one derivatives as soluble guanylyl cyclase (sGC) activators
Design, synthesis and biological evaluation of new 3,4-dihydroquinoxalin-2(1H)-one derivatives as soluble guanylyl cyclase (sGC) activators Open
Herein, we present the structure-based design, synthesis and biological evaluation of novel mono- and di-carboxylic 3,4-dihydroquinoxalin-2(1H)-one derivatives as potential heme-independent activators of soluble guanylate cyclase (s…
View article: A Cloud-based Distributed Computing Approach for Extracting Molecular Descriptors
A Cloud-based Distributed Computing Approach for Extracting Molecular Descriptors Open
Feature extraction is an initial and essential part for the development of accurate predictive machine learning classifiers. In the research field of drug discovery and development, the usage of molecular descriptors, which can be defined …
View article: Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration
Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration Open
Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and α ν β 3 integrin. Screening for proteins that interact with RPTPβ/ζ and potentially regulate PTN sign…
View article: Cytogenetic effects by newly synthesized antineoplastic steroidal alkylators in cultured human lymphocytes
Cytogenetic effects by newly synthesized antineoplastic steroidal alkylators in cultured human lymphocytes Open