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View article: Resistance to neoadjuvant chemotherapy in breast cancers: a metabolic perspective
Resistance to neoadjuvant chemotherapy in breast cancers: a metabolic perspective Open
Neoadjuvant chemotherapy (NAC) is a cornerstone in the treatment of early-stage high-risk breast cancers (BC), particularly in triple-negative, HER2-positive, and selected hormone receptor-positive subtypes. However, its effectiveness is f…
View article: PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma
PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma Open
Anti-epidermal growth factor receptor (EGFR) therapy (cetuximab) shows a limited clinical benefit for patients with locally advanced or recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), due to the frequent occurrence of s…
View article: Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers
Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers Open
Background Neoadjuvant chemotherapy (NAC) is the standard of care for patients with early-stage triple negative breast cancers (TNBC). However, more than half of TNBC patients do not achieve a pathological complete response (pCR) after NAC…
View article: Therapeutic potential of extracellular vesicles derived from cardiac progenitor cells in rodent models of chemotherapy-induced cardiomyopathy
Therapeutic potential of extracellular vesicles derived from cardiac progenitor cells in rodent models of chemotherapy-induced cardiomyopathy Open
Background Current treatments of chemotherapy-induced cardiomyopathy (CCM) are of limited efficacy. We assessed whether repeated intravenous injections of human extracellular vesicles from cardiac progenitor cells (EV-CPC) could represent …
View article: Rbm24 displays dynamic functions required for myogenic differentiation during muscle regeneration
Rbm24 displays dynamic functions required for myogenic differentiation during muscle regeneration Open
Skeletal muscle has a remarkable capacity of regeneration after injury, but the regulatory network underlying this repair process remains elusive. RNA-binding proteins play key roles in the post-transcriptional regulation of gene expressio…
View article: Extracellular vesicles fail to trigger the generation of new cardiomyocytes in chronically infarcted hearts
Extracellular vesicles fail to trigger the generation of new cardiomyocytes in chronically infarcted hearts Open
Background: Extracellular vesicles (EV) mediate the therapeutic effects of stem cells but it is unclear whether this involves cardiac regeneration mediated by endogenous cardiomyocyte proliferation. Methods: Bi-transgenic MerCreMer/ZEG (n …
View article: Rbm24 Displays Dynamic Functions Required for Myogenic Differentiation During Muscle Regeneration
Rbm24 Displays Dynamic Functions Required for Myogenic Differentiation During Muscle Regeneration Open
Skeletal muscle has a remarkable capacity of regeneration after injury, but the cellular behavior and the regulatory network coordinating different steps of this repair process remain elusive. RNA-binding proteins play key roles in the pos…
View article: Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts
Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts Open
Aims The cardioprotective effects of human induced pluripotent stem cell-derived cardiovascular progenitor cells (CPC) are largely mediated by the paracrine release of extracellular vesicles (EV). We aimed to assess the immunological behav…