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View article: Assessment of a biometric shirt for sleep body position identification in epilepsy
Assessment of a biometric shirt for sleep body position identification in epilepsy Open
Background Patients with uncontrolled epilepsy are at increased risk of sudden unexpected death in epilepsy (SUDEP). Evidence suggests that sleeping prone or being in a prone position after a seizure may increase the risk of SUDEP. A few w…
View article: Detection of focal impaired awareness seizures using a biometric shirt
Detection of focal impaired awareness seizures using a biometric shirt Open
Objective In recent years, seizure detection using wearable technology has gained significant attention in research. Most studies, however, have focused on detecting generalized or focal to bilateral tonic–clonic seizures. This study evalu…
View article: Synovial Biomarkers C-Reactive Protein and Calprotectin for Diagnosing Chronic Periprosthetic Joint Infection: A Prospective Multicenter Evaluation
Synovial Biomarkers C-Reactive Protein and Calprotectin for Diagnosing Chronic Periprosthetic Joint Infection: A Prospective Multicenter Evaluation Open
The present study demonstrates that synovial calprotectin and synovial CRP assays have excellent accuracy for the diagnosis of PJI. These findings suggest that these two synovial biomarkers should be incorporated into a new decision-making…
View article: Insular Cortex Modulation by Repetitive Transcranial Magnetic Stimulation with Concurrent Functional Magnetic Resonance Imaging: Preliminary Findings
Insular Cortex Modulation by Repetitive Transcranial Magnetic Stimulation with Concurrent Functional Magnetic Resonance Imaging: Preliminary Findings Open
Background/Objectives: The insula is a deep, functionally heterogeneous region involved in various pathological conditions. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising therapeutic avenue for neuromodulati…
View article: Separating Subjective from Objective Food Value in the Human Insula: An Exploratory Study Using Intracranial EEG
Separating Subjective from Objective Food Value in the Human Insula: An Exploratory Study Using Intracranial EEG Open
Background/Objectives: The human insula is a key structure implicated in integrating internal states and external food cues, yet its precise role remains unclear, in part due to the temporal limitations of neuroimaging techniques like fMRI…
View article: Insular Cortex Modulation by Repetitive Transcranial Magnetic Stimulation with Concurrent Functional Magnetic Resonance Imaging: Preliminary Findings
Insular Cortex Modulation by Repetitive Transcranial Magnetic Stimulation with Concurrent Functional Magnetic Resonance Imaging: Preliminary Findings Open
Background/Objectives: The insula plays a role in various medical conditions, including eating disorders, addiction, and chronic pain. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising therapeutic avenue, yet f…
View article: Microelectrode Implantation in Human Insula: Technical Challenges and Recording Insights
Microelectrode Implantation in Human Insula: Technical Challenges and Recording Insights Open
Background/Objectives: Intracranial macroelectrode implantation is a pivotal clinical tool in the evaluation of drug-resistant epilepsy, allowing further insights into the localization of the epileptogenic zone and the delineation of eloqu…
View article: Microelectrode Implantation in Human Insula: Technical Challenges and Recording Insights
Microelectrode Implantation in Human Insula: Technical Challenges and Recording Insights Open
Background/Objectives: Intracranial macroelectrode implantation is a pivotal clinical tool in the evaluation of drug-resistant epilepsy, allowing further insights into the localization of the epileptogenic zone and the delineation of eloqu…
View article: Epidemiological and bacteriological trends from 2013 to 2023 of carbapenemase-producing enterobacterales (CPE) in a French university hospital: A permanent risk of outbreak
Epidemiological and bacteriological trends from 2013 to 2023 of carbapenemase-producing enterobacterales (CPE) in a French university hospital: A permanent risk of outbreak Open
CPE detection in the hospital was associated mainly with epidemic spread involving a variable number of secondary cases. CPE patients detected incidentally (without specific infection control measures) several days after hospital admission…
View article: Cortical hemodynamics of electrographic status epilepticus in the critically ill
Cortical hemodynamics of electrographic status epilepticus in the critically ill Open
Objectives The pathophysiological mechanisms of status epilepticus (SE) underlying potential brain injury remain largely unclear. This study aims to employ functional near‐infrared spectroscopy (fNIRS) combined with video‐electroencephalog…
View article: Detection of focal to bilateral tonic–clonic seizures using a connected shirt
Detection of focal to bilateral tonic–clonic seizures using a connected shirt Open
Objective This study was undertaken to develop and evaluate a machine learning‐based algorithm for the detection of focal to bilateral tonic–clonic seizures (FBTCS) using a novel multimodal connected shirt. Methods We prospectively recruit…
View article: Dampened circadian amplitude of <scp>EEG</scp> power in women after menopause
Dampened circadian amplitude of <span>EEG</span> power in women after menopause Open
Summary Postmenopausal women are at high risk of developing sleep–wake disturbances. We previously reported dampened circadian rhythms of melatonin, alertness and sleep in postmenopausal compared with young women. The present study aims to…
View article: Pain reflects the informational value of nociceptive inputs
Pain reflects the informational value of nociceptive inputs Open
Pain perception and its modulation are fundamental to human learning and adaptive behavior. This study investigated the hypothesis that pain perception is tied to pain’s learning function. Thirty-one participants performed a threat conditi…
View article: Unexpected cardiorespiratory findings postictally and at rest weeks prior to SUDEP
Unexpected cardiorespiratory findings postictally and at rest weeks prior to SUDEP Open
Introduction Mechanisms underlying sudden unexpected death in epilepsy (SUDEP) are unclear, but autonomic disorders are thought to play a critical role. However, those dysfunctions have mainly been reported in the peri-ictal context of gen…
View article: Decrease in wearable-based nocturnal sleep efficiency precedes epileptic seizures
Decrease in wearable-based nocturnal sleep efficiency precedes epileptic seizures Open
Introduction While it is known that poor sleep is a seizure precipitant, this association remains poorly quantified. This study investigated whether seizures are preceded by significant changes in sleep efficiency as measured by a wearable…
View article: Acute Effects of High-Frequency Insular Stimulation on Interictal Epileptiform Discharge Rates in Patients with Refractory Epilepsy
Acute Effects of High-Frequency Insular Stimulation on Interictal Epileptiform Discharge Rates in Patients with Refractory Epilepsy Open
Rationale: Deep brain stimulation (DBS) of several sites, such as the thalamus, has been shown to reduce seizure frequency and interictal epileptiform activity in patients with refractory epilepsy. Recent findings have demonstrated that th…
View article: The circadian variation of sleep and alertness of postmenopausal women
The circadian variation of sleep and alertness of postmenopausal women Open
Study Objectives Several factors may contribute to the high prevalence of sleep disturbances occurring in postmenopausal women. However, the contribution of the circadian timing system to their sleep disturbances remains unclear. In the pr…
View article: Multispectral intraoperative imaging for the detection of the hemodynamic response to interictal epileptiform discharges
Multispectral intraoperative imaging for the detection of the hemodynamic response to interictal epileptiform discharges Open
Interictal epileptiform discharges (IEDs) are brief neuronal discharges occurring between seizures in patients with epilepsy. The characterization of the hemodynamic response function (HRF) specific to IEDs could increase the accuracy of o…
View article: Heart Rate Variability in Insulo-Opercular Epilepsy
Heart Rate Variability in Insulo-Opercular Epilepsy Open
Background: We aimed to evaluate heart rate variability (HRV) changes in insulo-opercular epilepsy (IOE) and after insulo-opercular surgery. Methods: We analyzed 5-min resting HRV of IOE patients before and after surgery. Patients’ SUDEP-7…
View article: GP.5 Entropy on routine EEG: an interictal marker of seizure frequency?
GP.5 Entropy on routine EEG: an interictal marker of seizure frequency? Open
Background: Sample entropy (SampEn) can quantify the unpredictability of a physiological signal. We sought to assess if SampEn on EEG could reflect recent seizure activity. Methods: Charts of all patients undergoing an outpatient EEG betwe…
View article: 157 The Circadian Variation of Sleep in Postmenopausal Women
157 The Circadian Variation of Sleep in Postmenopausal Women Open
Introduction During menopause, 40-60% of women report sleep complaints. Despite the fact that menopause is associated with fluctuations in sex hormones that can affect circadian physiology, the role of circadian factors in sleep disturbanc…
View article: Large-Scale Desynchronization During Interictal Epileptic Discharges Recorded With Intracranial EEG
Large-Scale Desynchronization During Interictal Epileptic Discharges Recorded With Intracranial EEG Open
It is increasingly recognized that deep understanding of epileptic seizures requires both localizing and characterizing the functional network of the region where they are initiated, i. e., the epileptic focus. Previous investigations of t…
View article: Intervention Time and Adverse Events in a Canadian Epilepsy Monitoring Unit
Intervention Time and Adverse Events in a Canadian Epilepsy Monitoring Unit Open
Background: Intervention time (IT) in response to seizures and adverse events (AEs) have emerged as key elements in epilepsy monitoring unit (EMU) management. We performed an audit of our EMU, focusing on IT and AEs. Methods: We performed …
View article: Multispectral diffuse reflectance can discriminate blood vessels and bleeding during neurosurgery based on low-frequency hemodynamics
Multispectral diffuse reflectance can discriminate blood vessels and bleeding during neurosurgery based on low-frequency hemodynamics Open
A method based on multispectral reflectance signals and low-frequency hemoglobin concentration changes can be used to distinguish bleeding, blood vessels, and cortex. This could be integrated into fiber optic probes to enhance signal speci…
View article: Utility of magnetic source imaging in nonlesional focal epilepsy: a prospective study
Utility of magnetic source imaging in nonlesional focal epilepsy: a prospective study Open
OBJECTIVE For patients with nonlesional refractory focal epilepsy (NLRFE), localization of the epileptogenic zone may be more arduous than for other types of epilepsy and frequently requires information from multiple noninvasive presurgica…
View article: Magnetoencephalographic signatures of insular epileptic spikes based on functional connectivity
Magnetoencephalographic signatures of insular epileptic spikes based on functional connectivity Open
Failure to recognize insular cortex seizures has recently been identified as a cause of epilepsy surgeries targeting the temporal, parietal, or frontal lobe. Such failures are partly due to the fact that current noninvasive localization te…