Manon Vullings
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View article: Galectin-9 regulates dendritic cell polarity and uropod contraction by modulating RhoA activity
Galectin-9 regulates dendritic cell polarity and uropod contraction by modulating RhoA activity Open
Adaptive immunity relies on dendritic cell (DC) migration to transport antigens from tissues to lymph nodes. Galectins, a family of β-galactoside–binding proteins, control cell membrane organization, exerting crucial roles in multiple phys…
View article: Exploring immune status in peripheral blood and tumor tissue in association with survival in patients with multi-organ metastatic colorectal cancer
Exploring immune status in peripheral blood and tumor tissue in association with survival in patients with multi-organ metastatic colorectal cancer Open
Colorectal cancer (CRC) raises considerable clinical challenges, including a high mortality rate once the tumor spreads to distant sites. At this advanced stage, more accurate prediction of prognosis and treatment outcome is urgently neede…
View article: Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation
Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation Open
Growth hormone (GH) acts via JAK2 and LYN to regulate growth, metabolism, and neural function. However, the relationship between these tyrosine kinases remains enigmatic. Through an interdisciplinary approach combining cell biology, struct…
View article: Multisite assessment of reproducibility in high‐content cell migration imaging data
Multisite assessment of reproducibility in high‐content cell migration imaging data Open
View article: Multi-site assessment of reproducibility in high-content live cell imaging data
Multi-site assessment of reproducibility in high-content live cell imaging data Open
High-content image-based cell phenotyping provides fundamental insights in a broad variety of life science areas. Striving for accurate conclusions and meaningful impact demands high reproducibility standards, even more importantly with th…
View article: Tyrosine Kinases Compete for Growth Hormone Receptor Binding and Regulate Receptor Mobility and Degradation
Tyrosine Kinases Compete for Growth Hormone Receptor Binding and Regulate Receptor Mobility and Degradation Open
View article: Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion
Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion Open
View article: Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels
Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels Open
Progression of epithelial cancers predominantly proceeds by collective invasion of cell groups with coordinated cell–cell junctions and multicellular cytoskeletal activity. Collectively invading breast cancer cells express the gap junction…
View article: Leader cell activity and collective invasion by an autocrine nucleotide loop through connexin-43 hemichannels and ADORA1
Leader cell activity and collective invasion by an autocrine nucleotide loop through connexin-43 hemichannels and ADORA1 Open
Progression of epithelial cancers predominantly proceeds by collective invasion of cell groups with coordinated cell-cell junctions and multicellular cytoskeletal activity. Collectively invading breast cancer cells co-express adherens junc…
View article: Collective cancer invasion forms an integrin-dependent radioresistant niche
Collective cancer invasion forms an integrin-dependent radioresistant niche Open
Cancer fatalities result from metastatic dissemination and therapy resistance, both processes that depend on signals from the tumor microenvironment. To identify how invasion and resistance programs cooperate, we used intravital microscopy…
View article: Intravital microscopy of collective invasion plasticity in breast cancer
Intravital microscopy of collective invasion plasticity in breast cancer Open
Cancer invasion programs are adaptive by switching between metastatic collective and single-cell dissemination; however, current intravital microscopy models for epithelial cancer in mice fail to reliably recreate such invasion plasticity.…