ManoopS Bhutani
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View article: The plakin family: Potential therapeutic targets for digestive system tumors
The plakin family: Potential therapeutic targets for digestive system tumors Open
Digestive system tumors remain a global health challenge; however, the mechanisms underlying their tumorigenesis remain unclear. Identifying these mechanisms may facilitate early detection and more effective treatment. Members of the plaki…
View article: EUS-guided placement of fiducial markers for image-guided radiotherapy in gastrointestinal tumors
EUS-guided placement of fiducial markers for image-guided radiotherapy in gastrointestinal tumors Open
We present here a new chapter of the series of papers on how to perform specific EUS techniques. In this manuscript, we discuss on how to perform EUS-guided placement of fiducial markers in gastrointestinal tumors. The aim is to present th…
View article: Artificial intelligence: The new wave of innovation in EUS
Artificial intelligence: The new wave of innovation in EUS Open
INTRODUCTION During the past four decades, EUS has developed rapidly and has established itself as a vital tool in the diagnosis and treatment of digestive system diseases.[1] Nevertheless, there are still some limitations related to image…
View article: An international study of interobserver variability of “string sign” of pancreatic cysts among experienced endosonographers
An international study of interobserver variability of “string sign” of pancreatic cysts among experienced endosonographers Open
String sign of pancreatic cysts has a good interobserver agreement regarding its positivity that can help in differentiating mucinous from nonmucinous pancreatic cysts. However, the agreement is poor on the measured length of the string an…
View article: The EUS molecular evaluation of pancreatic cancer: A prospective multicenter cohort trial
The EUS molecular evaluation of pancreatic cancer: A prospective multicenter cohort trial Open
This trial is expected to provide crucial data regarding the feasibility of routine CGP of A-PDAC using EUS-FNA material. It will also provide important information about the impact of this methodology on patients' survival.
View article: EUS-through-the-needle microbiopsy forceps in pancreatic cystic lesions: A systematic review
EUS-through-the-needle microbiopsy forceps in pancreatic cystic lesions: A systematic review Open
Pancreatic cystic lesions (PCLs) are being increasingly encountered in clinical practice, and sometimes, they can represent a diagnostic challenge. Recently, a through-the-needle micro forceps biopsy (MFB) device was introduced in the endo…
View article: An international, multi-institution survey on performing EUS-FNA and fine needle biopsy
An international, multi-institution survey on performing EUS-FNA and fine needle biopsy Open
This is the first worldwide survey of EUS-FNA and FNB practice patterns. The results showed wide variations in practice patterns. Randomized studies are urgently needed to establish the best approach for optimizing the FNA/FNB procedures.
View article: Clinical impact of strain histogram EUS elastography and contrast-enhanced EUS for the differential diagnosis of focal pancreatic masses: A prospective multicentric study
Clinical impact of strain histogram EUS elastography and contrast-enhanced EUS for the differential diagnosis of focal pancreatic masses: A prospective multicentric study Open
The current study using objective parametric tools for both EUS elastography and contrast-enhanced EUS confirmed the results of previous studies and meta-analyses that indicated a complementary role for the differential diagnosis of focal …
View article: EUS and EUS-guided FNA/core biopsies in the evaluation of subepithelial lesions of the lower gastrointestinal tract: 10-year experience
EUS and EUS-guided FNA/core biopsies in the evaluation of subepithelial lesions of the lower gastrointestinal tract: 10-year experience Open
EUS-guided FNA/FNB are feasible and safe techniques for assessing lower GI SELs and provide valuable information regarding lesion characteristics and their malignant potential with high diagnostic accuracy.
View article: Quality of life impact of EUS in patients at risk for developing pancreatic cancer
Quality of life impact of EUS in patients at risk for developing pancreatic cancer Open
BACKGROUND AND OBJECTIVES: The current knowledge about the psychological impact of pancreatic cancer (PC) screening is limited. We aimed to assess the changes in quality of life (QOL) and level of distress after undergoing EUS in individua…
View article: Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): A study protocol
Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): A study protocol Open
Patients with unresectable pancreatic cancer have a poor prognosis. The analysis of prognostic factors before treatment may be helpful in determining the best therapeutic strategies. The aim of the PEACE study is to assess the vascularity …
View article: A multi-institution consensus on how to perform EUS-guided biliary drainage for malignant biliary obstruction
A multi-institution consensus on how to perform EUS-guided biliary drainage for malignant biliary obstruction Open
This is the first worldwide survey on the practice of EUS-BD for MBO. There were wide variations in practice, and randomized studies are urgently needed to establish the best approach for the management of this condition.
View article: EUS of an atypical ectopic pancreas
EUS of an atypical ectopic pancreas Open
A 43-year-old woman presented with abdominal pain, nausea, and vomiting. She underwent computed tomography of the abdomen and pelvis that showed a gastric subepithelial mass. Esophagogastroduodenoscopy (EGD) revealed a smooth subepithelial…
View article: A quarter century of EUS-FNA: Progress, milestones, and future directions
A quarter century of EUS-FNA: Progress, milestones, and future directions Open
Tissue acquisition using EUS has considerably evolved since the first EUS-FNA was reported 25 years ago. Its introduction was an important breakthrough in the endoscopic field. EUS-FNA has now become a part of the diagnostic and staging al…
View article: Has the role of EUS in rectal cancer staging changed in the last decade?
Has the role of EUS in rectal cancer staging changed in the last decade? Open
The need for effective diagnosis, staging, and treatment of rectal cancer cannot be overstated. Accurate staging of rectal cancer has wide-ranging implications, including therapeutic strategy and prognosis. A change in stage may lead to th…
View article: Can endoscopic ultrasound-guided needle-based confocal laser endomicroscopy replace fine-needle aspiration for pancreatic and mediastinal diseases?
Can endoscopic ultrasound-guided needle-based confocal laser endomicroscopy replace fine-needle aspiration for pancreatic and mediastinal diseases? Open
New applications of confocal laser endomicroscopy (CLE) have been developed, such as needle-based CLE (nCLE) for pancreatic masses, pancreatic cystic tumors, and lymph nodes. nCLE is feasible during endoscopic ultrasound (EUS) examination,…
View article: A multi-institutional consensus on how to perform endoscopic ultrasound-guided peri-pancreatic fluid collection drainage and endoscopic necrosectomy
A multi-institutional consensus on how to perform endoscopic ultrasound-guided peri-pancreatic fluid collection drainage and endoscopic necrosectomy Open
There is a lack of consensus on how endoscopic ultrasound (EUS)-guided pseudocyst drainage and endoscopic necrosectomy should be performed. This survey was carried out amongst members of the EUS Journal Editorial Board to describe their pr…
View article: A rare case of pancreatic metastasis of angiosarcoma: Diagnosed by endoscopic ultrasound-guided fine-needle aspiration and biopsy
A rare case of pancreatic metastasis of angiosarcoma: Diagnosed by endoscopic ultrasound-guided fine-needle aspiration and biopsy Open
A 55-year-old female, with primary splenic angiosarcoma with metastatic lesions in liver, T-8 vertebra and left femur, status postsplenectomy, right hepatectomy and cholecystectomy, and multiple cycles of chemotherapy, was found to have a …
View article: In vivo cytological observation of liver and spleen by using high-resolution microendoscopy system under endoscopic ultrasound guidance: A preliminary study using a swine model
In vivo cytological observation of liver and spleen by using high-resolution microendoscopy system under endoscopic ultrasound guidance: A preliminary study using a swine model Open
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is useful to obtain specimens from lesions underlying deep parts of the liver and spleen. However, the development of novel ancillary techniques must be explored to reduce the n…
View article: Prevalence of extra-pancreatic cysts in patients with cystic pancreatic lesions detected by endoscopic ultrasound
Prevalence of extra-pancreatic cysts in patients with cystic pancreatic lesions detected by endoscopic ultrasound Open
The prevalence of EPCs in patients with PCLs was significantly higher than in a matched control group. Among patients with PCLs, a liver cyst is the most common EPC. Increasing age is associated with higher prevalence of EPCs.