Mansour S. Alsaid
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View article: New terpenic and phenolic compounds from Suaeda monoica reverse oxidative and apoptotic damages in human endothelial cells
New terpenic and phenolic compounds from Suaeda monoica reverse oxidative and apoptotic damages in human endothelial cells Open
View article: A Polyphenols-Rich Extract from Moricandia sinaica Boiss. Exhibits Analgesic, Anti-Inflammatory and Antipyretic Activities In Vivo
A Polyphenols-Rich Extract from Moricandia sinaica Boiss. Exhibits Analgesic, Anti-Inflammatory and Antipyretic Activities In Vivo Open
In this study, the aerial parts of Moricandia sinaica were evaluated for their in vivo analgesic, anti-inflammatory and antipyretic activities. The analgesic activities were examined using acetic acid-induced writhing, the hot plate test a…
View article: Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats
Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats Open
Background Consumption of plant-derived nutraceuticals and crude drugs in Arab traditional medicine is widely believed to confer beneficial effects in liver and kidney diseases. Fruits from the date palm Phoenix dactylifera L. are a rich s…
View article: Cell proliferation activity delineated by molecular docking of four new compounds isolated from the aerial parts of Suaeda monoica Forssk. ex. J.F. Gmel
Cell proliferation activity delineated by molecular docking of four new compounds isolated from the aerial parts of Suaeda monoica Forssk. ex. J.F. Gmel Open
Using different chromatographic methods, four new compounds were isolated from the aerial parts of Suaeda monoica (Chenopodiaceae) along with 2-hydroxy-1-naphthoic acid (SCM-3). The structures of the new compounds were established a…
View article: Anti-inflammatory, antipyretic, analgesic, and antioxidant activities of Haloxylon salicornicum aqueous fraction
Anti-inflammatory, antipyretic, analgesic, and antioxidant activities of Haloxylon salicornicum aqueous fraction Open
The medicinal plant Haloxylon salicornicum is utilized for therapeutic purposes. We previously reported the antioxidant potential of hexane fraction and methanol extracts of the same species. However, since these solvents could be clinical…
View article: Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats
Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats Open
Our findings suggest the therapeutic potential of S. surattense against chemical-induced oxidative stress and liver damage. However, isolation of the active principles and elucidation of mechanism of action remain to be addressed.
View article: Phytochemical analysis and anti-diabetic, anti-inflammatory and antioxidant activities of Loranthus acaciae Zucc. Grown in Saudi Arabia
Phytochemical analysis and anti-diabetic, anti-inflammatory and antioxidant activities of Loranthus acaciae Zucc. Grown in Saudi Arabia Open
View article: Proanthocyanidins from the stem bark of Rhus tripartita ameliorate methylgloxal-induced endothelial cell apoptosis
Proanthocyanidins from the stem bark of Rhus tripartita ameliorate methylgloxal-induced endothelial cell apoptosis Open
In traditional Arabian medicine, the Rhus tripartita plant (family Anacardiaceae) has been used to treat inflammatory conditions. Although Rhus extracts have been reported for their cardioprotective effects, information regarding their act…
View article: Cytotoxic evaluation and concurrent analysis of two diterpenes in the chloroform extract of Plectranthus barbatus using a validated HPTLC-UV method
Cytotoxic evaluation and concurrent analysis of two diterpenes in the chloroform extract of Plectranthus barbatus using a validated HPTLC-UV method Open
The objective of this study was to develop a validated high-performance thin layer chromatography (HPTLC) method for the concurrent analysis of two diterpenes Sugiol (compound 1) and 11,14-dihydroxy-8,11,13-abietatrien-7-one (compound 2) i…
View article: Comparative evaluation of cytotoxic, antimicrobial and antioxidant activities of the crude extracts of three Plectranthus species grown in Saudi Arabia
Comparative evaluation of cytotoxic, antimicrobial and antioxidant activities of the crude extracts of three Plectranthus species grown in Saudi Arabia Open
Natural products from medicinal plants represent major resource of novel therapeutic substances for combating serious diseases including cancers and microbial infections. The genus Plectranthus (Family: Labiatae) represents a large …
View article: Incidence, Risk Factors, and Epidemiology of Cystic Echinococcosis: A Complex Socioecological Emerging Infectious Disease in Khyber Pakhtunkhwa, Province of Pakistan
Incidence, Risk Factors, and Epidemiology of Cystic Echinococcosis: A Complex Socioecological Emerging Infectious Disease in Khyber Pakhtunkhwa, Province of Pakistan Open
Cystic echinococcosis is a serious zoonotic disease caused by Echinococcus granulosus species complex. The current study is the first attempt to determine the level of infection in domestic livestock and to explore the CE-related knowledge…
View article: Glycyrrhiza glabra HPLC fractions: identification of Aldehydo Isoophiopogonone and Liquirtigenin having activity against multidrug resistant bacteria
Glycyrrhiza glabra HPLC fractions: identification of Aldehydo Isoophiopogonone and Liquirtigenin having activity against multidrug resistant bacteria Open
View article: Synthesis of Cephradine Metal Complexes and its Anti-bacterial Evaluation
Synthesis of Cephradine Metal Complexes and its Anti-bacterial Evaluation Open
Cephradine belongs to the first generation cephalosporin having a broad range of anti-bacterial activities.In the present work, Cephradine wasreacted with different metal salts.These metal salts were Iron, Copper, Cobalt and Nickel salts.A…
View article: Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachlorideinduced Hepatotoxicity in Rats
Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachlorideinduced Hepatotoxicity in Rats Open
The detoxification, metabolism, and excretion of various endogenous and exogenous materials occur mainly in the liver. Liver diseases are a global concern, and classified as chronic hepatitis, cirrhosis, and hepatosis. The development of s…
View article: Traditional uses of medicinal plants practiced by the indigenous communities at Mohmand Agency, FATA, Pakistan
Traditional uses of medicinal plants practiced by the indigenous communities at Mohmand Agency, FATA, Pakistan Open
View article: Assessment of biochemical parameters and genotoxicity of rice (Oryza sativa) variation treated with zinc sulfate and boric acid.
Assessment of biochemical parameters and genotoxicity of rice (Oryza sativa) variation treated with zinc sulfate and boric acid. Open
Zinc sulfate and boric corrosive are transcendently utilized as manufactured composts for rice cropping system in Pakistan. The present research work was conducted to investigate the adverse effects of these fertilizers at 150 and 350 mg/L…
View article: Hepatoprotective Effect of <i>Eriobotrya japonica</i> Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats
Hepatoprotective Effect of <i>Eriobotrya japonica</i> Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats Open
Eriobotrya japonica is traditionally used as an antipyretic, digestive, and diuretic agent. Its flowers possess free radical–scavenging, antioxidative, and hepatoprotective effects. We investigated the hepatoprotective potential of E. japo…
View article: Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors
Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors Open
Targeting EGFR has proven to be beneficial in the treatment of several types of solid tumours. So, a series of novel 2-(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-ylthio)-N-substituted acetamide 5-19 were synthesised from …
View article: Discovery of Benzo[g]quinazolin benzenesulfonamide derivatives as dual EGFR/HER2 inhibitors
Discovery of Benzo[g]quinazolin benzenesulfonamide derivatives as dual EGFR/HER2 inhibitors Open
View article: Teratogenic Effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus)
Teratogenic Effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus) Open
The present study was designed to assess the teratogenic effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus). Different doses of commercial Chlorantraniliprole (0.1, 0.5, 1.0 and 1.5µl/1000µl/egg, in four experimenta…
View article: Synthesis, antimicrobial activity and docking study of some novel 4-(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino derivatives carrying biologically active sulfonamide moiety
Synthesis, antimicrobial activity and docking study of some novel 4-(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino derivatives carrying biologically active sulfonamide moiety Open
A new series of 4-((4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino)-N-(substituted)benzenesulfonamide 3–17, monosubstituted 2-((4-((4-aminophenyl)sulfonyl)phenyl)amino)methylene 18, and its disubstituted derivative 19 were synthesized f…
View article: Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety
Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety Open
View article: Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules
Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules Open
View article: Crystal structure of 4-(2-ammonioethyl)morpholin-4-ium dichloride monohydrate, C<sub>6</sub>H<sub>18</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub>
Crystal structure of 4-(2-ammonioethyl)morpholin-4-ium dichloride monohydrate, C<sub>6</sub>H<sub>18</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub> Open
C 6 H 18 Cl 2 N 2 O 2 , triclinic, P 1̅ (no. 2), a = 7.9597(11) Å, b = 9.1223(13) Å, c = 9.2893(12) Å, α = 118.575(3)°, β = 106.507(4)°, γ = 97.120(4)°, V = 540.21(13) Å 3 , Z = 2, R gt ( F ) = 0.0470, wR ref ( F 2 ) = 0.1156, T = 293 K.
View article: Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking
Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking Open
View article: A novel monocyclic triterpenoid and a norsesquaterpenol from the aerial parts of Suaeda monoica Forssk. ex J.F. Gmel with cell proliferative potential
A novel monocyclic triterpenoid and a norsesquaterpenol from the aerial parts of Suaeda monoica Forssk. ex J.F. Gmel with cell proliferative potential Open
Suaeda monoica Forssk. ex J.F. Gmel (Chenopodiaceae), a mangrove herb, is distributed in tropical Africa, Arabian Peninsula, India, Pakistan, Palestine and Jordan. The plant parts are used to treat sore throat, hepatitis, wounds, rh…
View article: Crystal structure of the co-crystalline adduct 4-((4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino)-<i>N</i>-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide - acetic acid (1/1), C<sub>21</sub>H<sub>24</sub>N<sub>4</sub>O<sub>4</sub>S ⋅ C<sub>2</sub>H<sub>4</sub>O<sub>2</sub>
Crystal structure of the co-crystalline adduct 4-((4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino)-<i>N</i>-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide - acetic acid (1/1), C<sub>21</sub>H<sub>24</sub>N<sub>4</sub>O<sub>4</sub>S ⋅ C<sub>2</sub>H<sub>4</sub>O<sub>2</sub> Open
C 23 H 28 N 4 O 6 S, triclinic, P 1̅ (no. 2), a = 7.3612(3) Å, b = 9.2370(4) Å, c = 19.2940(8) Å, α = 94.657(2)°, β = 96.902(2)°, γ = 113.010(2)°, V = 1186.92(9) Å 3 , Z = 2, R gt ( F ) = 0.0617, wR ref ( F 2 ) = 0.1575, T = 100 K.
View article: Study of effects of selenium and Vitamin E on Liver physiology in Fayoumi
Study of effects of selenium and Vitamin E on Liver physiology in Fayoumi Open
Vitamin E is familiar for its antioxidative properties for neutralizing oxide radicals and plays a role to keep cells safe from physiological damage and Selenium being an integral part of Glutathione peroxidase assists Vit.E and help chick…
View article: New Cytotoxic Seco-Type Triterpene and Labdane-Type Diterpenes from Nuxia oppositifolia
New Cytotoxic Seco-Type Triterpene and Labdane-Type Diterpenes from Nuxia oppositifolia Open
Chromatographic purification of the n-hexane and dichloromethane extracts of Nuxia oppositifolia aerial parts, growing in Saudi Arabia, resulted in the isolation and characterization of three new labdane-type diterpene acids, 2β-acetoxy-la…
View article: Chemical Composition, In Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas inflata Benth
Chemical Composition, In Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas inflata Benth Open
The essential oil of Leucas inflata Balf.f. (Lamiaceae), collected in Yemen, was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. Forty-three components were recognized, representing 89.2%…