Mansour Sobeh
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View article: Protective Effects of Cuscuta australis Against CCl4-Induced Hepatic Injury in Rats: Antioxidant, Anti-Inflammatory, and In Silico Insights
Protective Effects of Cuscuta australis Against CCl4-Induced Hepatic Injury in Rats: Antioxidant, Anti-Inflammatory, and In Silico Insights Open
Background/Objectives: The search for new bioactive molecules increasingly extends beyond conventional medicinal plants, highlighting the importance of exploring alternative botanical sources. Parasitic plants represent a promising but und…
View article: Correction: Ghareeb et al. Chemical Profiling of Polyphenolics in Eucalyptus globulus and Evaluation of Its Hepato–Renal Protective Potential Against Cyclophosphamide Induced Toxicity in Mice. Antioxidants 2019, 8, 415
Correction: Ghareeb et al. Chemical Profiling of Polyphenolics in Eucalyptus globulus and Evaluation of Its Hepato–Renal Protective Potential Against Cyclophosphamide Induced Toxicity in Mice. Antioxidants 2019, 8, 415 Open
In the original publication [...]
View article: Defense Mechanisms of Chickpea against Chickpea Pod Borer, <i>Helicoverpa armigera</i> and Chickpea Leafminer, <i>Liriomyza cicerina</i>: from Plant Morphology to Molecular Level
Defense Mechanisms of Chickpea against Chickpea Pod Borer, <i>Helicoverpa armigera</i> and Chickpea Leafminer, <i>Liriomyza cicerina</i>: from Plant Morphology to Molecular Level Open
Chickpea is cultivated in more than 50 countries around the world, with a growing market reaching more than USD 11 billion worldwide. The annual production of chickpeas is around 1 t/ha, which is less than the expected yield of 6 t/ha when…
View article: Comprehensive identification of chemical fingerprint and potential quality markers of leaves and roots of two Aloe species via LC–MS/MS and computational analyses in relation to anti-virulence activity
Comprehensive identification of chemical fingerprint and potential quality markers of leaves and roots of two Aloe species via LC–MS/MS and computational analyses in relation to anti-virulence activity Open
Background Over the past centuries , Aloe species have been traditionally used in managements of infectious ailments. However, no scientific investigation has been conducted into their mechanistic actions behind their antimicrobial activit…
View article: Bioactivity screening of selected Moroccan medicinal and aromatic plants, and the chemical basis of the phytotoxicity of caper, Capparis spinosa L.
Bioactivity screening of selected Moroccan medicinal and aromatic plants, and the chemical basis of the phytotoxicity of caper, Capparis spinosa L. Open
View article: Role of natural plant extracts and hyaluronic acid derivatives in intranasal strategies for brain delivery. A review
Role of natural plant extracts and hyaluronic acid derivatives in intranasal strategies for brain delivery. A review Open
In the last two decades, different routes of administration have been explored for the treatment of central nervous system (CNS) disorders, involving biomolecules and drugs. Among them, transmucosal route is gaining particular interest, du…
View article: Impact of Field Insect Pests on Seed and Nutritional Quality of Some Important Crops: A Comprehensive Review
Impact of Field Insect Pests on Seed and Nutritional Quality of Some Important Crops: A Comprehensive Review Open
The increasing problem of insect pest infestation in agriculture and its impact on crop production and productivity require a thorough understanding and identification of efficient control solutions. This review explores the effects of ins…
View article: Ethnobotanical survey of medicinal and aromatic plants used by the population of Settat Province, Morocco
Ethnobotanical survey of medicinal and aromatic plants used by the population of Settat Province, Morocco Open
View article: Rapid Detection of Aspergillus spp. and Quantitative Simultaneous Analysis of Aflatoxins (B1, B2, G1 and G2) in Kenyan Hybrid Maize Cultivars Using FT-IR and LC-ESI-MS/MS Spectro-analysis Techniques
Rapid Detection of Aspergillus spp. and Quantitative Simultaneous Analysis of Aflatoxins (B1, B2, G1 and G2) in Kenyan Hybrid Maize Cultivars Using FT-IR and LC-ESI-MS/MS Spectro-analysis Techniques Open
The present study combined Fourier-Transform Infrared Spectroscopy (FT-IR) analysis with high resolution liquid chromatography tandem mass spectroscopy equipped with an electrospray ionization source (LC-ESI-MS/MS) in the screening and qua…
View article: Unveiling the Cardiopreventive Effect of the Parasitic Weed Orobanche Crenata Forsk. Extract Against Isoproterenol-Induced Myocardial Infarction in Rats
Unveiling the Cardiopreventive Effect of the Parasitic Weed Orobanche Crenata Forsk. Extract Against Isoproterenol-Induced Myocardial Infarction in Rats Open
View article: Database mining of ZINC15 natural compounds reveals potential thyroid receptor β agonists for NAFLD management: an <i>in silico</i> study
Database mining of ZINC15 natural compounds reveals potential thyroid receptor β agonists for NAFLD management: an <i>in silico</i> study Open
A multi-step docking–MD–MM/GBSA workflow reduced 47 199 ZINC15 natural compounds to two THR-β-selective agonists guided by key Arg316 contacts and provided promising clues for NAFLD treatment.
View article: Corrigendum to “Uxi (Endopleura uchi (Huber) Cuatrec) bark extract mitigates HFD-induced adiposity in rats via targeting oxidative stress, and lipogenic genes expression” [J. Funct. Foods 114 (2024) 106034]
Corrigendum to “Uxi (Endopleura uchi (Huber) Cuatrec) bark extract mitigates HFD-induced adiposity in rats via targeting oxidative stress, and lipogenic genes expression” [J. Funct. Foods 114 (2024) 106034] Open
View article: Correction: Mahmoud et al. Coriander Oil Reverses Dexamethasone-Induced Insulin Resistance in Rats. Antioxidants 2022, 11, 441
Correction: Mahmoud et al. Coriander Oil Reverses Dexamethasone-Induced Insulin Resistance in Rats. Antioxidants 2022, 11, 441 Open
In the original publication [...]
View article: Correction: Selim et al. Impact of Washingtonia robusta Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition. Pharmaceuticals 2020, 13, 320
Correction: Selim et al. Impact of Washingtonia robusta Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition. Pharmaceuticals 2020, 13, 320 Open
In the original publication [...]
View article: Inhibitory effects of wild Origanum elongatum extracts on Fusarium oxysporum mycelium growth and spores germination: Evidence from in-vitro, in-planta, and in-silico experiments
Inhibitory effects of wild Origanum elongatum extracts on Fusarium oxysporum mycelium growth and spores germination: Evidence from in-vitro, in-planta, and in-silico experiments Open
View article: Author Correction: Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats
Author Correction: Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats Open
View article: Correction: Sobeh et al. HPLC-PDA-MS/MS Characterization of Bioactive Secondary Metabolites from Turraea fischeri Bark Extract and Its Antioxidant and Hepatoprotective Activities In Vivo. Molecules 2017, 22, 2089
Correction: Sobeh et al. HPLC-PDA-MS/MS Characterization of Bioactive Secondary Metabolites from Turraea fischeri Bark Extract and Its Antioxidant and Hepatoprotective Activities In Vivo. Molecules 2017, 22, 2089 Open
The authors wish to emphasize that the experiments were simultaneously conducted with several plant species, and identical control groups were utilized for both articles (Phytomedicine (2017), doi:10 [...]
View article: Cubeb (Piper cubeba L.): nutritional value, phytochemical profiling and dermacosmeceutical properties
Cubeb (Piper cubeba L.): nutritional value, phytochemical profiling and dermacosmeceutical properties Open
Introduction Cubeb, Piper cubeba L., has been used for centuries in traditional medicine and culinary practices, with a wide range of biological and pharmacological activities. Objective Herein, we determined the phytochemical profile, min…
View article: The First Comprehensive Chemical Profiling of <i>Vachellia gummifera</i> (Willd.) Kyal. & Boatwr., a Plant with Medicinal Value
The First Comprehensive Chemical Profiling of <i>Vachellia gummifera</i> (Willd.) Kyal. & Boatwr., a Plant with Medicinal Value Open
Vachellia gummifera (Willd.) Kyal. & Boatwr. is a medicinal plant endemic to Morocco that has no documented studies on its chemical composition. In this study, the chemical composition of the water/methanol (4 : 1) extracts of air‐dried le…
View article: Ammodaucus leucotrichus Coss. & Dur. Attenuates acrylamide-induced hepatic injury through enhancing autophagy and inhibiting endoplasmic reticulum stress and apoptotic signaling
Ammodaucus leucotrichus Coss. & Dur. Attenuates acrylamide-induced hepatic injury through enhancing autophagy and inhibiting endoplasmic reticulum stress and apoptotic signaling Open
In our study, we investigated the potential of Ammodaucus leucotrichus Coss. & Dur. (Al) seed extract and essential oil (Al oil) to mitigate acrylamide-induced liver injury in rats. We administered the extract (100 and 200 mg/kg), essentia…
View article: Profiling of Petroselinum sativum (mill.) fuss phytoconstituents and assessment of their biocompatibility, antioxidant, anti-aging, wound healing, and antibacterial activities
Profiling of Petroselinum sativum (mill.) fuss phytoconstituents and assessment of their biocompatibility, antioxidant, anti-aging, wound healing, and antibacterial activities Open
Petroselinum sativum , known as parsley, is a fragrant herb that possesses a rich heritage of utilization in traditional medicinal practices. In this study, we annotated the phytocontents of the aqueous and ethanolic extracts of P. sativum…
View article: Mentha rotundifolia (L.) Huds. and Salvia officinalis L. hydrosols mitigate aging related comorbidities in rats
Mentha rotundifolia (L.) Huds. and Salvia officinalis L. hydrosols mitigate aging related comorbidities in rats Open
Introduction Aging is often linked to oxidative stress, where the body experiences increased damage from free radicals. Plants are rich sources of antioxidants, playing a role in slowing down aging and supporting the proper functioning and…
View article: Black pepper (Piper nigrum L.) essential oil counteracts dexamethasone-induced hepatic injury via modulating PGC-1α/ PPAR-α pathway in rats
Black pepper (Piper nigrum L.) essential oil counteracts dexamethasone-induced hepatic injury via modulating PGC-1α/ PPAR-α pathway in rats Open
We previously characterized the volatile compounds of black pepper (Piper nigrum) essential oil (BPEO) and demonstrated its mitigating effect against dexamethasone-induced pancreatic damage. Herein, we investigated the protective effect of…
View article: Chemical profiling and bioactivities of essential oils from Thymus capitatus and Origanum compactum against Tribolium castaneum
Chemical profiling and bioactivities of essential oils from Thymus capitatus and Origanum compactum against Tribolium castaneum Open
The use of essential oils has emerged as an ecofriendly solution for controlling different pests, particularly insects of stored products. Essential oils (EOs) from Thymus capitatus (TC) and Origanum compactum (OC) have recei…
View article: Ipomoea carnea mitigates ethanol-induced ulcers in irradiated rats via Nrf2/HO−1 pathway: an in vivo and in silico study
Ipomoea carnea mitigates ethanol-induced ulcers in irradiated rats via Nrf2/HO−1 pathway: an in vivo and in silico study Open
View article: Uxi (Endopleura uchi (Huber) Cuatrec) bark extract mitigates HFD-induced adiposity in rats via targeting oxidative stress, and lipogenic genes expression
Uxi (Endopleura uchi (Huber) Cuatrec) bark extract mitigates HFD-induced adiposity in rats via targeting oxidative stress, and lipogenic genes expression Open
Here, we compared the modulatory effects of different dose levels of Uxi (Endopleura uchi aqueous bark extract, EUAE) vs simvastatin (SIM) on hyperlipidemia, metabolic stress, and liver dysfunction in HFD-induced obese rats. HFD significan…
View article: Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer cells
Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer cells Open
Natural products have long been utilized in traditional medicine as remedies to improve health and treat illnesses, and have had a key role in modern drug discovery. Recently, there has been a revived interest in the search for bioactives …
View article: Chemical composition, antioxidant properties, and antifungal activity of wild Origanum elongatum extracts against Phytophthora infestans
Chemical composition, antioxidant properties, and antifungal activity of wild Origanum elongatum extracts against Phytophthora infestans Open
Introduction Phytophthora infestans , the causative agent of late blight disease, has gained notoriety for its destructive potential, leading to substantial losses in potato yields. Although conventional systemic fungicides have been shown…
View article: Tetraclinis articulata (Vahl) Mast.: Volatile constituents, antioxidant, antidiabetic and wound healing activities of its essential oil
Tetraclinis articulata (Vahl) Mast.: Volatile constituents, antioxidant, antidiabetic and wound healing activities of its essential oil Open
View article: Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments
Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments Open
The phytoconstituents of the aqueous extract from Syzygium jambos L. (Alston) leaves were defined using HPLC-PDA-MS/MS and the antioxidant, anti-aging, antibacterial, and anti-biofilm activities of the extract were in silico and in vitro i…