Mansour Taghavi Azar Sharabiani
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View article: Towards goal-directed perfusion - Part II: Temperature dependence of Q <sub>10</sub> , oxygen-demand dependence on age and weight, further clinical insights
Towards goal-directed perfusion - Part II: Temperature dependence of Q <sub>10</sub> , oxygen-demand dependence on age and weight, further clinical insights Open
Background Goal-directed perfusion (GDP) during cardiopulmonary bypass (CPB) seeks to match oxygen delivery with patient-specific metabolic demand, yet determinants of oxygen demand and dynamics of oxygen extraction ratio (OER) are not wel…
View article: Are we getting better over time? Clinical and patient-reported outcomes for reverse shoulder arthroplasty: a National Joint Registry cohort study
Are we getting better over time? Clinical and patient-reported outcomes for reverse shoulder arthroplasty: a National Joint Registry cohort study Open
Objectives This study aims to review whether both clinical and Patient Reported Outcome Measures (PROMs) of Reverse Shoulder Arthroplasty have improved over time using the National Joint Registry (NJR). Design This study is a population-ba…
View article: GenAI exceeds clinical experts in predicting acute kidney injury following paediatric cardiopulmonary bypass
GenAI exceeds clinical experts in predicting acute kidney injury following paediatric cardiopulmonary bypass Open
The emergence of large language models (LLMs) opens new horizons to leverage, often unused, information in clinical text. Our study aims to capitalise on this new potential. Specifically, we examine the utility of text embeddings generated…
View article: Exploring associations between active school environments and children’s physical activity, mental health and educational performance in Greater London primary schools: the Health and Activity of Pupils in the Primary Years (HAPPY) study protocol
Exploring associations between active school environments and children’s physical activity, mental health and educational performance in Greater London primary schools: the Health and Activity of Pupils in the Primary Years (HAPPY) study protocol Open
Introduction School environments that encourage children to be physically active can embed lifelong positive health behaviours and contribute towards reducing health inequalities. The Health and Activity of Pupils in the Primary Years (HAP…
View article: GenAI Exceeds Clinical Experts in Predicting Acute Kidney Injury following Paediatric Cardiopulmonary Bypass
GenAI Exceeds Clinical Experts in Predicting Acute Kidney Injury following Paediatric Cardiopulmonary Bypass Open
The emergence of large language models (LLMs) opens new horizons to leverage, often unused, information in clinical text. Our study aims to capitalise on this new potential. Specifically, we examine the utility of text embeddings generated…
View article: Multimorbidity, health service use, and health insurance by socioeconomic groups in 31 countries: a multi-cohort study
Multimorbidity, health service use, and health insurance by socioeconomic groups in 31 countries: a multi-cohort study Open
The prevalence of physical, psychological, and cognitive multimorbidity is marked by socioeconomic status (SES) inequalities. However, the relationship between multimorbidity patterns—particularly those involving cognitive conditions—and h…
View article: Improving the Detection of Potential Cases of Familial Hypercholesterolemia: Could Machine Learning Be Part of the Solution?
Improving the Detection of Potential Cases of Familial Hypercholesterolemia: Could Machine Learning Be Part of the Solution? Open
Background Familial hypercholesterolemia (FH), while highly prevalent, is a significantly underdiagnosed monogenic disorder. Improved detection could reduce the large number of cardiovascular events attributable to poor case finding. We ai…
View article: GenAI Exceeds Clinical Experts in Predicting Acute Kidney Injury following Paediatric Cardiopulmonary Bypass<sup>2</sup>
GenAI Exceeds Clinical Experts in Predicting Acute Kidney Injury following Paediatric Cardiopulmonary Bypass<sup>2</sup> Open
The emergence of large language models (LLMs) offers new opportunities to leverage, often unused, information in clinical text. This study examines the utility of text embeddings generated by LLMs in predicting postoperative acute kidney i…
View article: Mathematical Modelling of Oxygenation Dynamics using High-Resolution Perfusion Data – Part 1: Statistical Framework
Mathematical Modelling of Oxygenation Dynamics using High-Resolution Perfusion Data – Part 1: Statistical Framework Open
Background Balancing oxygen supply and demand during cardiopulmonary bypass (CPB) is crucial to minimise adverse outcomes. This is managed by adjusting oxygen delivery components – cardiac index (CI), haemoglobin concentration (Hb), arteri…
View article: Machine learning identification of carriers of pathogenic and likely pathogenic variants linked to familial hypercholesterolaemia in the UK Biobank
Machine learning identification of carriers of pathogenic and likely pathogenic variants linked to familial hypercholesterolaemia in the UK Biobank Open
View article: Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England: a retrospective cohort study
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England: a retrospective cohort study Open
View article: What is the suitability of clinical vignettes in benchmarking the performance of online symptom checkers? An audit study
What is the suitability of clinical vignettes in benchmarking the performance of online symptom checkers? An audit study Open
Objective Assess the suitability of clinical vignettes in benchmarking the performance of online symptom checkers (OSCs). Design Observational study using a publicly available free OSC. Participants Healthily OSC, which provided consultati…
View article: IDF21-0206 Historical cardiometabolic trajectories in T2D patients by dementia status in England by sex, ethnicity, and deprivation
IDF21-0206 Historical cardiometabolic trajectories in T2D patients by dementia status in England by sex, ethnicity, and deprivation Open
View article: Risk of Covid-19 in shielded and nursing care home patients: cohort study in general practice
Risk of Covid-19 in shielded and nursing care home patients: cohort study in general practice Open
Background: Covid-19 cases were first detected in the UK in January 2020 and vulnerable patients were asked to shield from March to reduce their risk of Covid-19 infection. Aim: To determine the risk and determinants of Covid-19 diagnosis …
View article: What is the suitability of clinical vignettes in benchmarking the performance of online symptom checkers? An audit study
What is the suitability of clinical vignettes in benchmarking the performance of online symptom checkers? An audit study Open
Objective To assess the suitability of primary care vignettes in benchmarking the performance of online symptom checkers Design Observational study using publicly available, free online symptom checkers Participants Three symptom checkers …
View article: Prevalence of Familial Hypercholesterolemia Among the General Population and Patients With Atherosclerotic Cardiovascular Disease
Prevalence of Familial Hypercholesterolemia Among the General Population and Patients With Atherosclerotic Cardiovascular Disease Open
Background: Contemporary studies suggest that familial hypercholesterolemia (FH) is more frequent than previously reported and increasingly recognized as affecting individuals of all ethnicities and across many regions of the world. Precis…
View article: Corrigendum to ‘Age over 35 years is associated with increased mortality after pulmonary valve replacement in repaired tetralogy of Fallot: results from the UK National Congenital Heart Disease Audit database’ [Eur J Cardiothorac Surg 2020;58:825–31]
Corrigendum to ‘Age over 35 years is associated with increased mortality after pulmonary valve replacement in repaired tetralogy of Fallot: results from the UK National Congenital Heart Disease Audit database’ [Eur J Cardiothorac Surg 2020;58:825–31] Open
View article: Age over 35 years is associated with increased mortality after pulmonary valve replacement in repaired tetralogy of Fallot: results from the UK National Congenital Heart Disease Audit database
Age over 35 years is associated with increased mortality after pulmonary valve replacement in repaired tetralogy of Fallot: results from the UK National Congenital Heart Disease Audit database Open
OBJECTIVES Many adults with repaired tetralogy of Fallot will require a pulmonary valve replacement (PVR), but there is no consensus on the best timing. In this study, we aim to evaluate the impact of age at PVR on outcomes. METHODS This i…
View article: Protocol for developing a core outcome set for evaluating school-based physical activity interventions in primary schools.
Protocol for developing a core outcome set for evaluating school-based physical activity interventions in primary schools. Open
INTRODUCTION:Primary school-based physical activity interventions, such as The Daily Mile initiative, have the potential to increase children's physical activity levels over time, which is associated with a variety of health benefits. Comp…
View article: Protocol for developing a core outcome set for evaluating school-based physical activity interventions in primary schools
Protocol for developing a core outcome set for evaluating school-based physical activity interventions in primary schools Open
Introduction Primary school-based physical activity interventions, such as The Daily Mile initiative, have the potential to increase children’s physical activity levels over time, which is associated with a variety of health benefits. Comp…
View article: Clinical and cost-effectiveness of the Ross procedure versus conventional aortic valve replacement in young adults
Clinical and cost-effectiveness of the Ross procedure versus conventional aortic valve replacement in young adults Open
Objectives In young and middle-aged adults, there are three current options for aortic valve replacement (AVR), namely mechanical AVR (mechAVR), tissue AVR (biological AVR) and the Ross operation, with no clear guidance on the best option.…
View article: Primary repair versus surgical and transcatheter palliation in infants with tetralogy of Fallot
Primary repair versus surgical and transcatheter palliation in infants with tetralogy of Fallot Open
Objectives Treatment of infants with tetralogy of Fallot (ToF) has evolved in the last two decades with increasing use of primary surgical repair (PrR) and transcatheter right ventricular outflow tract palliation (RVOTd), and fewer systemi…
View article: 971The burden of reinterventions after common arterial trunk repair in infants: contemporary results from a national database
971The burden of reinterventions after common arterial trunk repair in infants: contemporary results from a national database Open
View article: A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer
A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer Open
View article: Aortic Valve Replacement and the Ross Operation in Children and Young Adults
Aortic Valve Replacement and the Ross Operation in Children and Young Adults Open
View article: Long-term survival after surgical aortic valve replacement among patients over 65 years of age
Long-term survival after surgical aortic valve replacement among patients over 65 years of age Open
Objective Surgical aortic valve replacement (AVR) remains the gold standard therapy for severe aortic stenosis. Long-term survival data following AVR is required. Our objective was to provide a detailed contemporary benchmark of long-term …
View article: Outcomes following repair of anomalous coronary artery from the pulmonary artery in infants: results from a procedure-based national database
Outcomes following repair of anomalous coronary artery from the pulmonary artery in infants: results from a procedure-based national database Open
Background Anomalous coronary artery from the pulmonary artery (ACAPA) is a very rare congenital anomaly that often occurs during infancy. Patients can present in a critical condition. Methods We analysed procedure-related data from a nati…
View article: Alignment of metabolic trajectories with application to metabonomic toxicology
Alignment of metabolic trajectories with application to metabonomic toxicology Open
Geometry of the metabolic trajectories is characteristic of the biological response (Keun, Ebbels et al. 2004). Yet, due to unavoidable inter-individual variations, the exact trajectories characterising the biological responses differ. We …