Explanipedia

A rapid and robust luciferase-based reporter system to assess SARS-CoV-2 protease activity Open

Lucas Alessandro, Donnici Lorena, Nodari Riccardo, Longo Minnolo Marika, Ferraro Anastasia , et al. · 2025

Despite effective antiviral drugs that have emerged to combat SARS-CoV-2 infections, novel therapeutic strategies are required to better address the ongoing and future evolutions of the virus. Targeting viral proteases, such as the main pr…

Chronic mycobacteria infection triggers macrophage senescence Open

Edoardo Scarpa, D. Oliveri, Giorgia Moschetti, Anna Griego, Angelo Vianello , et al. · 2024

Chronic infections with intracellular pathogens such as Mycobacterium abscessus ( Mab ) pose significant health challenges due to their capacity to persist within host cells and evade immune responses. This study investigates the cellular …

Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells Open

Manuel Albanese, Hong‐Ru Chen, Madeleine Gapp, Maximilian Muenchhoff, Hsiu-Hui Yang , et al. · 2024

Autoantibody-Enhanced, CD32-Driven Trogocytosis Creates Functional Plasticity of Immune Cells and is Hijacked by HIV-1 to Infect Resting CD4 T Cells Open

Manuel Albanese, Hong‐Ru Chen, Madeleine Gapp, Maximilian Muenchhoff, Hsiu-Hui Yang , et al. · 2023

Strategies of Epstein-Barr virus to evade innate antiviral immunity of its human host Open

Manuel Albanese, Takanobu Tagawa, Wolfgang Hammerschmidt · 2022

Epstein-Barr virus (EBV) is a double-stranded DNA virus of the Herpesviridae family. This virus preferentially infects human primary B cells and persists in the human B cell compartment for a lifetime. Latent EBV infection can lead to the …

Unterdrückung der SARS‐CoV‐2‐Replikation mit stabilisierten und durch Klick‐Chemie modifizierten siRNAs Open

Franziska R. Traube, Marcel Stern, Annika J. Tölke, Martina Rudelius, Ernesto Mejías‐Pérez , et al. · 2022

Die Entstehung von leichter übertragbaren oder aggressiveren Varianten von SARS‐CoV‐2 erfordert die Entwicklung von antiviralen Medikamenten, die schnell an sich entwickelnde virale Escape ‐Mutationen anpassbar sind. Hier berichten wir übe…

Suppression of SARS‐CoV‐2 Replication with Stabilized and Click‐Chemistry Modified siRNAs Open

Franziska R. Traube, Marcel Stern, Annika J. Tölke, Martina Rudelius, Ernesto Mejías‐Pérez , et al. · 2022

The emergence of more transmissible or aggressive variants of SARS‐CoV‐2 requires the development of antiviral medication that is quickly adjustable to evolving viral escape mutations. Here we report the synthesis of chemically stabilized …

Quantitation of SARS-CoV-2 neutralizing antibodies with a virus-free, authentic test Open

Johannes Roessler, Dagmar Pich, Manuel Albanese, Paul R. Wratil, Verena Krähling , et al. · 2022

Neutralizing antibodies (NAbs), and their concentration in sera of convalescents and vaccinees are a correlate of protection from COVID-19. The antibody concentrations in clinical samples that neutralize SARS-CoV-2 are difficult and very c…

Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern Open

Paul R. Wratil, Marcel Stern, Alina Priller, Annika Willmann, Giovanni Almanzar , et al. · 2022

Superior immunity that allows neutralization of all SARS-CoV-2 variants of concern develops in COVID-19 convalescents and naïve individuals after three vaccinations Open

Ulrike Protzer, Paul R. Wratil, Marcel Stern, Alina Priller, Annika Willmann , et al. · 2022

Infection-neutralizing antibody responses after SARS-CoV-2 infection or COVID-19 vaccination are an essential part of antiviral immunity. This immune protection is challenged by the occurrence of SARS-CoV-2 variants of concern (VoCs) with …

LFA1 and ICAM1 are critical for fusion and spread of murine leukemia virus in vivo Open

Rebecca Engels, L A Falk, Manuel Albanese, Oliver T. Keppler, Xaver Sewald · 2022

Quantitation of SARS-CoV-2 neutralizing antibodies with a virus-free, authentic test Open

Johannes Roessler, Dagmar Pich, Manuel Albanese, Paul R. Wratil, Verena Krähling , et al. · 2021

Neutralizing antibodies (NAbs), and their concentration in sera of convalescents and vaccinees are a solid correlate of protection from COVID-19. The antibody concentrations in clinical samples that neutralize SARS-CoV-2 are difficult and …

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses Open

Manuel Albanese, Adrian Ruhle, Jennifer Mittermaier, Ernesto Mejías‐Pérez, Madeleine Gapp , et al. · 2021

CD4 + T cells are central mediators of adaptive and innate immune responses and constitute a major reservoir for human immunodeficiency virus (HIV) in vivo. Detailed investigations of resting human CD4 + T cells have been precluded by the …

MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells Open

Manuel Albanese, Yen‐Fu Adam Chen, Corinna Hüls, Kathrin Gärtner, Takanobu Tagawa , et al. · 2021

Mammalian cells release different types of vesicles, collectively termed extracellular vesicles (EVs). EVs contain cellular microRNAs (miRNAs) with an apparent potential to deliver their miRNA cargo to recipient cells to affect the stabili…

In-depth profiling of COVID-19 risk factors and preventive measures in healthcare workers Open

Paul R. Wratil, Niklas A. Schmacke, Andreas Osterman, Tobias Weinberger, Jochen Rech , et al. · 2021

Purpose To determine risk factors for coronavirus disease 2019 (COVID-19) in healthcare workers (HCWs), characterize symptoms, and evaluate preventive measures against SARS-CoV-2 spread in hospitals. Methods In a cross-sectional study cond…

Contribution of Heptose Metabolites and the cag Pathogenicity Island to the Activation of Monocytes/Macrophages by Helicobacter pylori Open

Larissa Faass, Saskia C. Stein, Martina Hauke, Madeleine Gapp, Manuel Albanese , et al. · 2021

The human gastric pathogen Helicobacter pylori activates human epithelial cells by a particular combination of mechanisms, including NOD1 and ALPK1-TIFA activation. These mechanisms are characterized by a strong participation of the bacter…

Highly efficient CRISPR-Cas9-mediated gene knockout in primary human B cells for functional genetic studies of Epstein-Barr virus infection Open

Ezgi Akidil, Manuel Albanese, Alexander Buschle, Adrian Ruhle, Dagmar Pich , et al. · 2021

Gene editing is now routine in all prokaryotic and metazoan cells but has not received much attention in immune cells when the CRISPR-Cas9 technology was introduced in the field of mammalian cell biology less than ten years ago. This versa…

Multiple Viral microRNAs Regulate Interferon Release and Signaling Early during Infection with Epstein-Barr Virus Open

Mickaël Bouvet, Stefanie Voigt, Takanobu Tagawa, Manuel Albanese, Yen‐Fu Adam Chen , et al. · 2021

Acute antiviral functions of all nucleated cells rely on type I interferon (IFN-I) pathways triggered upon viral infection. Host responses encompass the sensing of incoming viruses, the activation of specific transcription factors that ind…

Abstracts of the 10th German/Austrian AIDS Conference Open

Christian Hoffmann, Oliver T. Keppler, Christoph D. Spinner, Maximilian Muenchhoff, Julia Roider , et al. · 2021

Introduction: A prophylactic HIV vaccine would ideally induce protective immunity during childhood, prior to sexual debut.Children develop potent broadly neutralising antibody (bnAb) responses faster and at higher frequencies than adults, …

LFA1 and ICAM1 are Critical for Fusion and Spread of Murine Leukemia Virus <i>in vivo</i> Open

Rebecca Engels, L A Falk, Manuel Albanese, Oliver T. Keppler, Xaver Sewald · 2021

Multiple viral microRNAs regulate interferon release and signaling early during infection with Epstein-Barr virus Open

Mickaël Bouvet, Stefanie Voigt, Takanobu Tagawa, Manuel Albanese, Yen‐Fu Adam Chen , et al. · 2020

Epstein-Barr virus (EBV), a human herpes virus, encodes 44 microRNAs (miRNAs), which regulate many genes with various functions in EBV-infected cells. Multiple target genes of the EBV miRNAs have been identified, some of which play importa…

Highly efficient CRISPR-Cas9-mediated gene knockout in primary human B cells for functional genetic studies of Epstein-Barr virus infection Open

Ezgi Akidil, Manuel Albanese, Alexander Buschle, Adrian Ruhle, Oliver T. Keppler , et al. · 2020

Gene editing is now routine in all prokaryotic and metazoan cells but has not received much attention in immune cells when the CRISPR-Cas9 technology was introduced in the field of mammalian cell biology less than ten years ago. This versa…

CARD8 inflammasome activation triggers pyroptosis in human T cells Open

Andreas Linder, Stefan Bauernfried, Yiming Cheng, Manuel Albanese, Christophe Jung , et al. · 2020

Micro RNAs are minor constituents of extracellular vesicles and are hardly delivered to target cells Open

Manuel Albanese, Yen‐Fu Adam Chen, Corinna Hüls, Kathrin Gärtner, Takanobu Tagawa , et al. · 2020

Mammalian cells release different types of vesicles, collectively termed extracellular vesicles (EVs). EVs contain cellular microRNAs (miRNAs) with an apparent potential to deliver their miRNA cargo to recipient cells to affect the stabili…

Table of Contents Open

Asoka Banno, Sowmya P. Lakshmi, A. Rama Mohan Reddy, Seong H. Kim, Raju C. Reddy , et al. · 2019

Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1–Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice Open

Simon Danisch, Constanze Slabik, Angela Cornelius, Manuel Albanese, Takanobu Tagawa , et al. · 2018

Multi-Step Regulation of the TLR4 Pathway by the miR-125a~99b~let-7e Cluster Open

Graziella Curtale, Tiziana A. Renzi, Massimiliano Mirolo, Lorenzo Drufuca, Manuel Albanese , et al. · 2018

An appropriate immune response requires a tight balance between pro- and anti-inflammatory mechanisms. IL-10 is induced at late time-points during acute inflammatory conditions triggered by TLR-dependent recognition of infectious agents an…

Role of Epstein-Barr virus microRNAs in viral immune evasion Open

Manuel Albanese · 2018

MicroRNAs of Epstein-Barr Virus Control Innate and Adaptive Antiviral Immunity Open

Manuel Albanese, Takanobu Tagawa, Alexander Buschle, Wolfgang Hammerschmidt · 2017

Epstein-Barr virus (EBV) has established lifelong infection in more than 90% of humanity. While infection is usually controlled by the immune system, the human host fails to completely eliminate the pathogen. Several herpesviral proteins a…

Epstein–Barr virus microRNAs reduce immune surveillance by virus-specific CD8 <sup>+</sup> T cells Open

Manuel Albanese, Takanobu Tagawa, Mickaël Bouvet, Liridona Maliqi, Dominik Lutter , et al. · 2016

Significance Most humans are infected for their lifetime with Epstein–Barr virus (EBV), which can cause cancer and other EBV-associated diseases. Infected individuals develop strong immune responses to this virus, in particular cytotoxic C…

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