Manuel Baca
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View article: A human antibody specific for SIRPα reprograms macrophages and promotes antibody mediated anti-cancer activity
A human antibody specific for SIRPα reprograms macrophages and promotes antibody mediated anti-cancer activity Open
Several T cell immune checkpoint blockade therapies have shown initial successes in multiple cancers. However, significant issues remain, including tumor relapse, severe toxicities, and a lack of efficacy in most patients. SIRPα, commonly …
View article: IL13Rα2-Targeting Antibodies for Immuno-PET in Solid Malignancies
IL13Rα2-Targeting Antibodies for Immuno-PET in Solid Malignancies Open
Interleukin-13 receptor α-2 (IL13Rα2) is a cell surface receptor frequently expressed in solid malignancies, such as glioblastoma and melanoma, with limited expression in healthy tissue, rendering it an ideal target for noninvasive and spe…
View article: Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach
Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach Open
Hijacking the ubiquitin proteasome system to elicit targeted protein degradation (TPD) has emerged as a promising therapeutic strategy to target and destroy intracellular proteins at the post-translational level. Small molecule-based TPD a…
View article: Supplementary Figure 4 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 4 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 98K, Supplementary Figure S4: Caspase activation by G6T8.
View article: Supplementary Figure 3 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 3 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 59K, Supplementary Figure S3: G6T8 is specific for human TRAILR2 and does not cross-react with other TRAIL receptors.
View article: Supplementary Figure 4 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 4 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 98K, Supplementary Figure S4: Caspase activation by G6T8.
View article: Supplementary Figure 3 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 3 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 59K, Supplementary Figure S3: G6T8 is specific for human TRAILR2 and does not cross-react with other TRAIL receptors.
View article: Supplementary Methods from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Methods from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 95K
View article: Supplementary Figure 1 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 1 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 63K, Identification of BRAFV600E splice variant lacking exons 2-10 in dabrafenib resistant WMD009 tumour and derived cell line.
View article: Data from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Data from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
Activation of TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) can induce apoptosis in a variety of human cancer cell lines and xenografts, while lacking toxicity in normal cells. The natural ligand and agonistic antibodies show …
View article: Supplementary Figure 2 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 2 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 85K, Supplementary Figure S2: Specificity of TRAILR2-induced cell killing. TRAIL-sensitive cell lines were incubated with 100pM G6T8 and different concentrations of soluble TRAILR2-Fc fusion protein.
View article: Supplementary Figure 5 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 5 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 148K, Supplementary Figure S5: G6T8 and G6T6 have similar cytotoxic activity on TRAIL-sensitive cell lines.
View article: Supplementary Figure 5 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 5 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 148K, Supplementary Figure S5: G6T8 and G6T6 have similar cytotoxic activity on TRAIL-sensitive cell lines.
View article: Supplementary Methods from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Methods from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 95K
View article: Supplementary Figure 2 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 2 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 85K, Supplementary Figure S2: Specificity of TRAILR2-induced cell killing. TRAIL-sensitive cell lines were incubated with 100pM G6T8 and different concentrations of soluble TRAILR2-Fc fusion protein.
View article: Data from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Data from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
Activation of TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) can induce apoptosis in a variety of human cancer cell lines and xenografts, while lacking toxicity in normal cells. The natural ligand and agonistic antibodies show …
View article: Supplementary Figure 1 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
Supplementary Figure 1 from Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis Open
PDF file - 63K, Identification of BRAFV600E splice variant lacking exons 2-10 in dabrafenib resistant WMD009 tumour and derived cell line.
View article: Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability
Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability Open
Group 1 innate lymphoid cells (ILCs), which comprise both natural killer (NK) cells and ILC1s, are important innate effectors that can also positively and negatively influence adaptive immune responses. The latter function is generally asc…
View article: 846 Pre-clinical validation of a FLT3L-fusion protein for dendritic cell expansion and anti-tumor efficacy
846 Pre-clinical validation of a FLT3L-fusion protein for dendritic cell expansion and anti-tumor efficacy Open
Background The ligand for the receptor tyrosine kinase FMS-like tyrosine kinase 3 (FLT3) plays an importantrole in hematopoiesis. FLT3 signaling is required for the differentiation andexpansion of dendritic cells. In the context of cancer …
View article: 847 Pharmacokinetics and pharmacodynamics of GS-3583 in cynomolgus monkeys
847 Pharmacokinetics and pharmacodynamics of GS-3583 in cynomolgus monkeys Open
Background The ligand for the receptor tyrosine kinase FMS-like tyrosine kinase 3 (FLT3) plays an importantrole in hematopoiesis. FLT3 signaling is required for the differentiation andexpansion of dendritic cells. In the context of cancer …
View article: Tdap maternal immunization and infant follow-up trials: Immunogenicity, transplacental transfer of pertussis antibodies, safety following pertussis immunization during pregnancy and its impact on infant pertussis immune response
Tdap maternal immunization and infant follow-up trials: Immunogenicity, transplacental transfer of pertussis antibodies, safety following pertussis immunization during pregnancy and its impact on infant pertussis immune response Open
This video supports the two published articles by KP Perrett, et al. Immunogenicity, transplacental transfer of pertussis antibodies and safety following pertussis immunization during pregnancy: Evidence from a randomized, placebo-controll…
View article: Crystal structure of the human 4-1BB/4-1BBL complex
Crystal structure of the human 4-1BB/4-1BBL complex Open
4-1BBL is a member of the tumor necrosis factor (TNF) superfamily and is the ligand for the TNFR superfamily receptor, 4-1BB. 4-1BB plays an immunomodulatory role in T cells and NK cells, and agonists of this receptor have garnered strong …
View article: A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties
A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties Open
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above th…
View article: A hingeless Fc fusion system for site-specific cleavage by IdeS
A hingeless Fc fusion system for site-specific cleavage by IdeS Open
Fusion of proteins to the Fc region of IgG is widely used to express cellular receptors and other extracellular proteins, but cleavage of the fusion partner is sometimes required for downstream applications. Immunoglobulin G-degrading enzy…
View article: Combining phage display with de novo protein sequencing for reverse engineering of monoclonal antibodies
Combining phage display with de novo protein sequencing for reverse engineering of monoclonal antibodies Open
The enormous diversity created by gene recombination and somatic hypermutation makes de novo protein sequencing of monoclonal antibodies a uniquely challenging problem. Modern mass spectrometry-based sequencing will rarely, if ever, provid…