Manuel Buscarlet
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View article: Reduction of clonal hematopoiesis mutation burden in coronary patients treated with low-dose colchicine
Reduction of clonal hematopoiesis mutation burden in coronary patients treated with low-dose colchicine Open
Clonal hematopoiesis involves mutations in hematopoietic stem/progenitor cells, which increase the risk of cardiovascular disease, particularly under pro-inflammatory conditions. This study assessed the impact of the anti-inflammatory medi…
View article: Interplay between hereditary and acquired factors determines the neutrophil counts in older individuals
Interplay between hereditary and acquired factors determines the neutrophil counts in older individuals Open
Blood cell production is a complex process, partly genetically determined and influenced by acquired factors. However, there is a paucity of data on how these factors interplay in the context of aging, which is associated with a myeloid pr…
View article: Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life
Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life Open
Pathological neovascularization in age-related macular degeneration (nvAMD) drives the principal cause of blindness in the elderly. While there is a robust genetic association between genes of innate immunity and AMD, genome-to-phenome rel…
View article: A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions
A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions Open
Individuals with age-related clonal hematopoiesis (CH) are at greater risk for hematologic malignancies and cardiovascular diseases. However, predictive preclinical animal models to recapitulate the spectrum of human CH are lacking. Throug…
View article: Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity Open
View article: Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation
Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation Open
View article: COCO/DAND5 inhibits developmental and pathological ocular angiogenesis
COCO/DAND5 inhibits developmental and pathological ocular angiogenesis Open
Neovascularization contributes to multiple visual disorders including age-related macular degeneration (AMD) and retinopathy of prematurity. Current therapies for treating ocular angiogenesis are centered on the inhibition of vascular endo…
View article: Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition Open
View article: High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential
High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential Open
Clonal hematopoiesis of indeterminate potential (CHIP) is predictive of hematological cancers and cardiovascular diseases, but the etiology of CHIP initiation and clonal expansion is unknown. Several lines of evidence suggest that proinfla…
View article: Macaque Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Disrupted Clones and Utility for Testing Therapeutic Approaches
Macaque Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Disrupted Clones and Utility for Testing Therapeutic Approaches Open
View article: Neuropilin-1 Deficiency on Myeloid Cells Promotes a Pro-inflammatory Phenotype while Inhibiting Choroidal Neovascularization.
Neuropilin-1 Deficiency on Myeloid Cells Promotes a Pro-inflammatory Phenotype while Inhibiting Choroidal Neovascularization. Open
View article: NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy
NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy Open
Significance Diabetic retinopathy is a major cause of blindness in the working population. The most common cause of visual impairment in diabetic patients is diabetic macular edema (DME). Roughly 40% of patients with DME respond poorly to …
View article: Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil
Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil Open
The recent characterization of clonal hematopoiesis in a large segment of the aging population has raised tremendous interest and concern alike. Mutations have been documented in genes associated with hematological cancers and in non-drive…
View article: Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host Open
View article: DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions
DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions Open
Key Points Somatic mutations driving clonal hematopoiesis occur mainly in DNMT3A and TET2 and have no significant impact on hematological phenotypes. There is a familial predisposition to acquire TET2 mutation.
View article: Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2
Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2 Open