Manuel Vázquez‐Carrera
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View article: Peroxisome Proliferator-Activated Receptors (PPARs): A Themed Issue in Honor of Prof. Walter Wahli
Peroxisome Proliferator-Activated Receptors (PPARs): A Themed Issue in Honor of Prof. Walter Wahli Open
It is with great pleasure that we introduce this Special Issue dedicated to Peroxisome Proliferator-Activated Receptors (PPARs), honoring the pioneering contributions of Professor Walter Wahli [...]
View article: Serum Growth Differentiation Factor 15 (GDF15) Levels Reflect Ischemic Etiology in Heart Failure Patients with Iron Deficiency: A Cross-Sectional Study
Serum Growth Differentiation Factor 15 (GDF15) Levels Reflect Ischemic Etiology in Heart Failure Patients with Iron Deficiency: A Cross-Sectional Study Open
Heart failure (HF), particularly of an ischemic etiology, is steadily increasing worldwide. Non-anemic iron deficiency (ID) is highly prevalent among HF patients, and it has been related to worse outcomes. Growth differentiation factor 15 …
View article: Update on the status of the IFMIF-DONES Test Systems
Update on the status of the IFMIF-DONES Test Systems Open
The IFMIF-DONES Test Systems (TS) gather the experimental facilities offered by the plant, as well as the ancillary systems providing supplies and services both to those facilities and the irradiation modules, the latter ones belonging to …
View article: On-Surface Synthesis of a Large-Scale 2D MOF with Competing π–d Ferromagnetic/Antiferromagnetic Order
On-Surface Synthesis of a Large-Scale 2D MOF with Competing π–d Ferromagnetic/Antiferromagnetic Order Open
Metal-organic frameworks (MOFs) represent an interesting class of versatile materials with important properties, including magnetism. However, the synthesis of atomically precise large-scale 2D MOFs with nontrivial strong magnetic coupling…
View article: GADD45A suppression contributes to cardiac remodeling by promoting inflammation, fibrosis and hypertrophy
GADD45A suppression contributes to cardiac remodeling by promoting inflammation, fibrosis and hypertrophy Open
The growth arrest and DNA damage inducible 45A (GADD45A) is a multifaceted protein associated with stress signaling and cellular injury. Aside its well-established tumor suppressor activity, recent studies point to additional roles for GAD…
View article: GDF15 Circulating Levels Are Associated with Metabolic-Associated Liver Injury and Atherosclerotic Cardiovascular Disease
GDF15 Circulating Levels Are Associated with Metabolic-Associated Liver Injury and Atherosclerotic Cardiovascular Disease Open
There is growing evidence linking growth differentiation factor 15 (GDF15) to both metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiovascular (CV) risk. Nevertheless, the potential relationship between circulating …
View article: FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice
FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice Open
This study investigated the effects of fat mass and obesity-associated (FTO) inhibition on cognitive function and metabolic parameters of senescence-accelerated mouse prone 8 (SAMP8) mice fed a high-fat diet (HFD). SAMP8 mice fed an HFD ex…
View article: Monitoring On‐Surface Chemical Reactions by Low‐Energy Electron Microscopy: from Conformation Change to Ring Closure in 2D Molecular Gas
Monitoring On‐Surface Chemical Reactions by Low‐Energy Electron Microscopy: from Conformation Change to Ring Closure in 2D Molecular Gas Open
On‐surface synthesis is a promising strategy for the preparation of molecules that are not achievable otherwise. Understanding the mechanism of on‐surface reactions requires knowledge of the molecular structure and possible organization of…
View article: Palmitate potentiates the SMAD3-PAI-1 pathway by reducing nuclear GDF15 levels
Palmitate potentiates the SMAD3-PAI-1 pathway by reducing nuclear GDF15 levels Open
Nuclear growth differentiation factor 15 (GDF15) reduces the binding of the mothers’ against decapentaplegic homolog (SMAD) complex to its DNA-binding elements. However, the stimuli that control this process are unknown. Here, we examined …
View article: PPARβ/δ upregulates the insulin receptor β subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels
PPARβ/δ upregulates the insulin receptor β subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels Open
Overall, these findings reveal that PPARβ/δ activation increases InsRβ levels by alleviating ER stress and lysosomal degradation.
View article: Rapid diagnosis and severity scale of post-COVID condition using advanced spectroscopy
Rapid diagnosis and severity scale of post-COVID condition using advanced spectroscopy Open
The COVID-19 pandemic has resulted in a persistent health challenge known as Post-COVID Condition (PCC), characterized by symptoms lasting at least three months after the initial SARS-CoV-2 infection and potentially persisting for several …
View article: The GDF15 3′ UTR Polymorphism rs1054564 Is Associated with Diabetes and Subclinical Atherosclerosis
The GDF15 3′ UTR Polymorphism rs1054564 Is Associated with Diabetes and Subclinical Atherosclerosis Open
Growth differentiation factor 15 (GDF15) is a stress-response cytokine related to a wide variety of metabolic diseases. However, the impact of GDF15-specific genetic variants on the abovementioned conditions is poorly known. The aim of thi…
View article: Novel pentafluorosulfanyl-containing triclocarban analogs selectively kill Gram-positive bacteria
Novel pentafluorosulfanyl-containing triclocarban analogs selectively kill Gram-positive bacteria Open
Novel antimicrobial agents are needed to combat antimicrobial resistance. This study tested novel pentafluorosulfanyl-containing triclocarban analogs for their potential antibacterial efficacy. Standard procedures were used to produce pent…
View article: PPARs as Key Transcription Regulators at the Crossroads of Metabolism and Inflammation
PPARs as Key Transcription Regulators at the Crossroads of Metabolism and Inflammation Open
The metabolic and immune systems are complex networks of organs, cells, and proteins that are involved in the extraction of energy from food; this is to run complex cellular processes and defend the body against infections while protecting…
View article: Deletion of Gadd45a Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer’s Disease Hallmarks
Deletion of Gadd45a Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer’s Disease Hallmarks Open
Gadd45 genes have been implicated in survival mechanisms, including apoptosis, autophagy, cell cycle arrest, and DNA repair, which are processes related to aging and life span. Here, we analyzed if the deletion of Gadd45a activates pathway…
View article: On-Surface Synthesis of a Radical 2D Supramolecular Organic Framework
On-Surface Synthesis of a Radical 2D Supramolecular Organic Framework Open
The design of supramolecular organic radical cages and frameworks is one of the main challenges in supramolecular chemistry. Their interesting material properties and wide applications make them very promising for (photo)redox catalysis, s…
View article: GADD45A: With or without you
GADD45A: With or without you Open
The growth arrest and DNA damage inducible (GADD)45 family includes three small and ubiquitously distributed proteins (GADD45A, GADD45B, and GADD45G) that regulate numerous cellular processes associated with stress signaling and injury res…
View article: Novel Pentafluorosulfanyl-containing Triclocarban Analogs selectively kill Gram-positive bacteria
Novel Pentafluorosulfanyl-containing Triclocarban Analogs selectively kill Gram-positive bacteria Open
The antibacterial and antibiofilm efficacy of our novel pentafluorosulfanyl-containing triclocarban analogs was explored against seven different Gram-positive and Gram-negative indicator strains. After initial screening, they had bacterici…
View article: GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway
GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway Open
Overall, these findings indicate that GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis by lowering the activity of the TGF-β1/SMAD3 pathway.
View article: Elafibranor upregulates the EMT-inducer S100A4 via PPARβ/δ
Elafibranor upregulates the EMT-inducer S100A4 via PPARβ/δ Open
Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR)α and β/δ agonist that has reached a phase III clinical trial for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we examined t…
View article: On-surface synthesis of a radical 2D supramolecular organic framework
On-surface synthesis of a radical 2D supramolecular organic framework Open
The design of supramolecular organic radical cages and frameworks is one of the main challenges in supramolecular chemistry. Their interesting material properties and wide applications make them very promising for (photo)redox catalysis, s…
View article: Design and Synthesis of AMPK Activators and GDF15 Inducers
Design and Synthesis of AMPK Activators and GDF15 Inducers Open
Targeting growth differentiation factor 15 (GDF15) is a recent strategy for the treatment of obesity and type 2 diabetes mellitus (T2DM). Here, we designed, synthesized, and pharmacologically evaluated in vitro a novel series of AMPK activ…