Manuel J. Rial
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View article: Evolution of Disease Burden in Severe Asthma Patients by Biological Treatment Status: Interim Analysis of the BREATHE Study
Evolution of Disease Burden in Severe Asthma Patients by Biological Treatment Status: Interim Analysis of the BREATHE Study Open
The interim analysis of the BREATHE study reveals that severe asthma patients in Spain, predominantly female and around 50 years old, continue to experience exacerbations despite biological therapy, with nearly half having poorly controlle…
View article: Four-month real-life response to Tezepelumab in patients with multi-failure to other biologics
Four-month real-life response to Tezepelumab in patients with multi-failure to other biologics Open
To evaluate the response to Tezepelumab in real clinical practice, we performed an analysis of the clinical, functional, and inflammatory characteristics of 13 patients with severe asthma after completing four doses of Tezepelumab was perf…
View article: Editorial: A multidisciplinary approach to treatment of severe chronic airway disease (CAD): focus on biomarkers
Editorial: A multidisciplinary approach to treatment of severe chronic airway disease (CAD): focus on biomarkers Open
EDITORIAL article Front. Allergy, 02 February 2024Sec. Asthma Volume 5 - 2024 | https://doi.org/10.3389/falgy.2024.1357886
View article: Expert consensus on the use of systemic glucocorticoids for managing eosinophil-related diseases
Expert consensus on the use of systemic glucocorticoids for managing eosinophil-related diseases Open
Eosinophil-related diseases represent a group of pathologic conditions with highly heterogeneous clinical presentation and symptoms ranging from mild to critical. Both systemic and localized forms of disease are typically treated with gluc…
View article: Global Lung Initiative as Diagnostic Criteria in Asthma-COPD Overlap Syndrome: Prevalence and Disease Characterization in a Real-Life Asthma Cohort
Global Lung Initiative as Diagnostic Criteria in Asthma-COPD Overlap Syndrome: Prevalence and Disease Characterization in a Real-Life Asthma Cohort Open
Methods:Asthma was diagnosed based on the GEMA guidelines and included a postBD FEV1>12% and 200ml on spirometry and/or methacholine PC20<16 mg/ml.Study data included demographic and clinical characteristics, asthma treatment, asthma sever…
View article: Disposition of Work-Related Asthma in a Spanish Asthma Cohort: Comparison of Asthma Severity Between Employed and Retired Workers
Disposition of Work-Related Asthma in a Spanish Asthma Cohort: Comparison of Asthma Severity Between Employed and Retired Workers Open
The burden of WRA in specialized asthma units is not negligible. The absence of differences in the severity of asthma, the treatment administered, alterations in lung function, and the number of exacerbations in those working versus not wo…
View article: Effectiveness of nordic walking in patients with asthma: A study protocol of a randomized controlled trial
Effectiveness of nordic walking in patients with asthma: A study protocol of a randomized controlled trial Open
Background Patients with asthma often consider their symptomatology a barrier to exercise, leading to a reduced physical activity level. This study aims to determine whether the effect of a Nordic walking (NW) training program plus educati…
View article: Quality of life against seasonal vs perennial allergens: ESPRINT-15 modified in the pediatric population
Quality of life against seasonal vs perennial allergens: ESPRINT-15 modified in the pediatric population Open
Introduction: Allergic rhinitis (AR) is a clinical syndrome characterized by IgE-mediated inflammation of the nasal mucosa. The present study investigates the quality of life (QoL) with AR among adults, using widely validated questionnaire…
View article: How reliably can algorithms identify eosinophilic asthma phenotypes using non‐invasive biomarkers?
How reliably can algorithms identify eosinophilic asthma phenotypes using non‐invasive biomarkers? Open
Background and Aims Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non‐invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinica…
View article: Inflammatory Remission in T2 Severe Asthma
Inflammatory Remission in T2 Severe Asthma Open
OPINION article Front. Allergy, 30 May 2022Sec. Asthma https://doi.org/10.3389/falgy.2022.923083
View article: Exacerbations Among Patients With Asthma Are Largely Dependent on the Presence of Multimorbidity
Exacerbations Among Patients With Asthma Are Largely Dependent on the Presence of Multimorbidity Open
Introduction: Comorbidities can influence asthma control and promote asthma exacerbations (AEs). However, the impact of multimorbidity in AEs, assessed based on long-term follow-up of patients with asthma of different degrees of severity, …
View article: The Influence of Peripheral Blood Eosinophil Counts in Asthma Comorbidities in Adults: A Real Life Study
The Influence of Peripheral Blood Eosinophil Counts in Asthma Comorbidities in Adults: A Real Life Study Open
Asthma and eosinophilia are two closely related pathologies whose interaction is key in the era of precision medicine. However, this relationship is rarely taken into account without the influence of therapeutic prescriptions. In this stud…
View article: Effectiveness and safety of a microcrystalline tyrosine‐adjuvanted <i>Dermatophagoides pteronyssinus</i> allergoid immunotherapy in adult patients with allergic asthma and rhinitis: A real‐life prospective observational study
Effectiveness and safety of a microcrystalline tyrosine‐adjuvanted <i>Dermatophagoides pteronyssinus</i> allergoid immunotherapy in adult patients with allergic asthma and rhinitis: A real‐life prospective observational study Open
Introduction Although clinical trials have shown the efficacy and safety of allergen‐specific immunotherapy (AIT) in the treatment of allergic asthma, there is a need for real‐life studies. We aimed to assess the effectiveness and safety o…
View article: Smell improvement by anti-IgE and anti-IL 5 biologics in patients with CRSwNP and severe asthma. A real life study
Smell improvement by anti-IgE and anti-IL 5 biologics in patients with CRSwNP and severe asthma. A real life study Open
This is the first real-world study to compare improvement in olfaction among patients undergoing long-term treatment with omalizumab, mepolizumab, reslizumab, or benralizumab for severe asthma and associated CRSwNP. Approximately 4 out of …
View article: Changes in Serum MicroRNAs after Anti-IL-5 Biological Treatment of Severe Asthma
Changes in Serum MicroRNAs after Anti-IL-5 Biological Treatment of Severe Asthma Open
There is currently enough evidence to think that miRNAs play a role in several key points in asthma, including diagnosis, severity of the disease, and response to treatment. Cells release different types of lipid double-membrane vesicles i…
View article: Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort
Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort Open
Introduction The MEGA (MEchanism underlying the Genesis and evolution of Asthma) project is a multicenter cohort study carried out in eight Spanish hospitals, gathering clinical, physiological, and molecular data from patients with asthma …
View article: Serum microRNAs as Tool to Predict Early Response to Benralizumab in Severe Eosinophilic Asthma
Serum microRNAs as Tool to Predict Early Response to Benralizumab in Severe Eosinophilic Asthma Open
Severe eosinophilic asthma poses a serious health and economic problem, so new therapy approaches have been developed to control it, including biological drugs such as benralizumab, which is a monoclonal antibody that binds to IL-5 recepto…