Explanipedia

Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike and accessory proteins ORF7a and ORF8 Open

Annika Roth, Steffen Lütke, Matthias Mörgelin, Denise Meinberger, Gabriele Hermes , et al. · 2025

Background The role of vitamin D in Coronavirus Disease 2019 (COVID-19) outcomes remains debated, but emerging evidence suggests it may enhance recovery by strengthening immune responses. Vitamin D upregulates LL-37, an antimicrobial pepti…

SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling Open

Katharina Uphoff, Melina Hußmann, Dörte Schulte-Ostermann, Yvonne Huisman, Matthias Mörgelin , et al. · 2025

The molecular mechanisms that drive (lymph-)angiogenesis are crucial to understand diseases, such as lymphedema, that are caused due to malformations of the lymphatic vasculature. Recently an interaction between the secreted protein Svep1,…

SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling Open

Katharina Uphoff, Melina Hußmann, Dörte Schulte-Ostermann, Yvonne Huisman, Matthias Mörgelin , et al. · 2025

The molecular mechanisms that drive (lymph-)angiogenesis are crucial to understand diseases, such as lymphedema, that are caused due to malformations of the lymphatic vasculature. Recently an interaction between the secreted protein Svep1,…

Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages Open

Alexander Simonis, Sebastian J. Theobald, Alvaro Koch, Ram Mummadavarapu, Julie M Mudler , et al. · 2025

SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling Open

Katharina Uphoff, Melina Hußmann, Dörte Schulte-Ostermann, Yvonne Huisman, Matthias Mörgelin , et al. · 2025

The molecular mechanisms that drive (lymph-)angiogenesis are crucial to understand diseases, such as lymphedema, that are caused due to malformations of the lymphatic vasculature. Recently an interaction between the secreted protein Svep1,…

High rate of RNAemia and impaired immunity in patients with immunodeficiency in the vaccination era Open

Anne Thierbach, Veronica Di Cristanziano, Kirsten Alexandra Eberhardt, Martin Pirkl, Gertrud Steger , et al. · 2025

The study underscores the importance of humoral response in controlling SARS-CoV-2 replication. RNAemia can serve as a potential biomarker for disease severity in immunocompromised individuals. Therefore, it should be considered in clinica…

Prodomain processing controls <span>BMP</span> ‐10 bioactivity and targeting to fibrillin‐1 in latent conformation Open

Chara E. S. Spanou, Chengeng Yang, Alan R. Godwin, Stefanie A. Morosky, Arulselvi Anbalagan , et al. · 2025

Bone morphogenetic protein 10 (BMP‐10) is crucial for endothelial cell signaling via activin receptor‐like kinase 1 (ALK1), a pathway central to vascular homeostasis and angiogenesis. Dysregulated BMP‐10 signaling contributes to cardiovasc…

Detection of Sars-Cov-2 Rnaemia in Patients with Immunodeficiency in the Post-Covid 19 Vaccination Era Open

Anne Thierbach, Veronica Di Cristanziano, Kirsten Alexandra Eberhardt, Martin Pirkl, Gertrud Steger , et al. · 2025

A novel homozygous nonsense variant in <i>COL12A1</i> causes myopathic Ehlers‐Danlos syndrome: A case report and literature review Open

Rasha El Sherif, Yoshihiko Saito, Rasha S. Hussein, Yayoi Izu, Manuel Koch , et al. · 2024

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The data that support the findings of this study are available on re…

Spatial proteomics of skeletal muscle using thin cryosections reveals metabolic adaptation at the muscle-tendon transition zone Open

Luisa Schmidt, Michael Saynisch, Christian Hoegsbjerg, Andreas Schmidt, Abigail Mackey , et al. · 2024

Morphological studies of skeletal muscle tissue provide insights into the architecture of muscle fibers, the surrounding cells, and the extracellular matrix (ECM). However, a spatial proteomics analysis of the skeletal muscle including the…

Identifying the molecular basis of Laminin N-terminal domain Ca2+ binding using a hybrid approach Open

Scott Legare, Fabian Heide, Haben Gabir, Faride Rafiei, Markus Meier , et al. · 2024

Fibre type differences in the organisation of mononuclear cells and myonuclei at the tips of human myofibres Open

Christian Hoegsbjerg, Ask Møbjerg, Ching‐Yan Chloé Yeung, Peter Schjerling, Michael R. Krogsgaard , et al. · 2024

The myotendinous junction (MTJ) is a weak link in the musculoskeletal system. Here, we isolated the tips of single myofibres from healthy human hamstring muscles for confocal microscopy (n=6) and RNAscope in situ hybridization (n=6) to gai…

Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality Open

Marie‐Christine Albert, Iratxe Uranga-Murillo, Maykel Arias, Diego de Miguel, Natacha Peña , et al. · 2024

Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons Open

Laurie Nemoz-Billet, Martial Balland, Laurent Gilquin, Benjamin Gillet, Isabelle Stévant , et al. · 2024

During development, motor axons are guided toward muscle target by various extrinsic cues including extracellular matrix (ECM) proteins whose identities and cellular source remain poorly characterized. Here, using single-cell RNAseq of sor…

Implementation-Friendly Inverse Modeling of Building Thermodynamics for Predictive Demand Response Open

Manuel Koch, Parantapa Sawant, Ralph Eismann, Colin N. Jones · 2024

Implementation-Friendly Inverse Modeling of Building Thermodynamics for Predictive Demand Response Open

Manuel Koch, Parantapa Sawant, Ralph Eismann, Colin N. Jones · 2024

Osteoclast-specific Plastin 3 knockout in mice fail to develop osteoporosis despite dramatic increased osteoclast resorption activity Open

Ilka Maus, Maren Dreiner, Sebastian Zetzsche, Fabian Metzen, Bryony Ross , et al. · 2024

PLS3 loss-of-function mutations in humans and mice cause X-linked primary osteoporosis. However, it remains largely unknown how PLS3 mutations cause osteoporosis and which function PLS3 plays in bone homeostasis. A recent study showed that…

Age-related structural and functional changes of the intracardiac nervous system Open

Eliza Sassu, Gavin Tumlinson, Dragana Stefanovska, Marbely C. Fernández, Pia Iaconianni , et al. · 2023

Background Although aging is known to be associated with an increased incidence of both atrial and ventricular arrhythmias, there is limited knowledge about how Schwann cells (SC) and the intracardiac nervous system (iCNS) remodel with age…

Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa Open

Alexander Simonis, Christoph Kreer, Alexandra Albus, Katharina Rox, Biao Yuan , et al. · 2023

Drug-resistant Pseudomonas aeruginosa (PA) poses an emerging threat to human health with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and antibody response to the virulence-associated type III secretio…

The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm Open

Matthias Hamdorf, Thomas Imhof, Ben A. Bailey-Elkin, Janina Betz, Sebastian J. Theobald , et al. · 2023

The novel coronavirus pandemic, first reported in December 2019, was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection leads to a strong immune response and activation of antigen-presenting ce…

Chemokine Binding to Tenascin-C Influences Chemokine-Induced Immune Cell Migration Open

Alissa Domaingo, Philipp Jokesch, Alexandra Schweiger, Martha Gschwandtner, Tanja Gerlza , et al. · 2023

Tenascin-C (TNC) is a complex glycoprotein of the extracellular matrix (ECM) involved in a plethora of (patho-)physiological processes, such as oncogenesis and inflammation. Since chemokines play an essential role in both disease processes…

Fibroblast-derived matrix models desmoplastic properties and forms a prognostic signature in cancer progression Open

Maria Rafaeva, Adina R. D. Jensen, Edward R. Horton, Kamilla Westarp Zornhagen, Jan E. Strøbech , et al. · 2023

The desmoplastic reaction observed in many cancers is a hallmark of disease progression and prognosis, particularly in breast and pancreatic cancer. Stromal-derived extracellular matrix (ECM) is significantly altered in desmoplasia, and as…

Ablation of collagen XII disturbs joint extracellular matrix organization and causes patellar subluxation Open

Mengjie Zhu, Fabian Metzen, Mark Hopkinson, Janina Betz, Juliane Heilig , et al. · 2023

Collagen XII, belonging to the fibril-associated collagens, is a homotrimeric secreted extracellular matrix (ECM) protein encoded by the COL12A1 gene. Mutations in the human COL12A1 gene cause an Ehlers-Danlos/myopathy overla…

Dual-topology of collagen XV and tenascin C acts in concert to guide and shape developing motor axons Open

Laurie Nemoz-Billet, Martial Balland, Laurent Gilquin, Benjamin Gillet, Isabelle Stévant , et al. · 2023

During development, motor axons are guided towards their muscle target by various extrinsic cues including extracellular matrix (ECM) proteins those identities remain poorly documented. Using single-cell RNA-sequencing of differentiating s…

Dissecting the impact of somatic hypermutation on SARS-CoV-2 neutralization and viral escape Open

Michael Korenkov, Matthias Zehner, Hadas Cohen‐Dvashi, Aliza Borenstein-Katz, Lisa Kottege , et al. · 2023

SUMMARY Somatic hypermutation (SHM) drives affinity maturation and continues over months in SARS-CoV-2 neutralizing antibodies. Yet, several potent SARS-CoV-2 antibodies carry no or only few mutations, leaving the question of how ongoing S…

Investigating Chemokine-Matrix Networks in Breast Cancer: Tenascin-C Sets the Tone for CCL2 Open

Martha Gschwandtner, Anís N. Gammage, Claire Deligne, Linda F. M. Mies, Alissa Domaingo , et al. · 2023

Bidirectional dialogue between cellular and non-cellular components of the tumor microenvironment (TME) drives cancer survival. In the extracellular space, combinations of matrix molecules and soluble mediators provide external cues that d…

A comparison of methods to eliminate regularization weight tuning from data-enabled predictive control Open

Manuel Koch, Colin N. Jones · 2023

Data-enabled predictive control (DeePC) is a recently established form of Model Predictive Control (MPC), based on behavioral systems theory. While eliminating the need to explicitly identify a model, it requires an additional regularizati…

Glycyrrhizic Acid Prevents Paclitaxel-Induced Neuropathy via Inhibition of OATP-Mediated Neuronal Uptake Open

Ines Klein, Jörg Isensee, Martin H. J. Wiesen, Thomas Imhof, Meike K. Wassermann , et al. · 2023

Peripheral neuropathy is a common side effect of cancer treatment with paclitaxel. The mechanisms by which paclitaxel is transported into neurons, which are essential for preventing neuropathy, are not well understood. We studied the uptak…

Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner Open

Melina Hußmann, Dörte Schulte, Sarah Weischer, Claudia Carlantoni, Hiroyuki Nakajima , et al. · 2023

Multiple factors are required to form functional lymphatic vessels. Here, we uncover an essential role for the secreted protein Svep1 and the transmembrane receptor Tie1 during the development of subpopulations of the zebrafish facial lymp…

Supplementary Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma Open

Caroline Spenlé, Thomas Loustau, Devadarssen Murdamoothoo, William Erne, Stephanie Beghelli-de la Forest Divonne , et al. · 2023

Supplemental Figures S1 - S7 Supplemental Tables S1 - S17

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