Manel Luján
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Muscle Unloading During Exercise: Comparative Effects of Conventional Oxygen, NIV, and High-Flow Therapy on Neural Drive in Severe COPD Open
Objectives: This study aimed to evaluate how non-invasive ventilation (NIV) and high-flow nasal cannula therapy (HFT) versus conventional oxygen therapy (COT) affect neural ventilatory drive during exercise in patients with severe chronic …
Preparedness for Blackouts in Iberian Peninsula Patients Using Home Respiratory Therapies Open
Background and Objectives Home respiratory therapies (HRT), including long-term oxygen therapy (LTOT) and home mechanical ventilation (HMV), are essential for patients with chronic respiratory diseases, yet their effectiveness depends on u…
View article: Exploring upper airway and laryngeal resistance to noninvasive ventilation in healthy awake adults
Exploring upper airway and laryngeal resistance to noninvasive ventilation in healthy awake adults Open
The interaction between anatomical structures, pressure, and airflow impacts the airway resistance. The airflow during noninvasive ventilation (NIV) relies on the upper airway and laryngeal patency. This study aimed to quantify the airflow…
Evidence on Non-Invasive Respiratory Support During Flexible Bronchoscopy: A Narrative Review Open
Background: Flexible bronchoscopy (FB) is a widely used diagnostic and therapeutic procedure in patients with pulmonary disease, many of whom are at risk of gas exchange impairment. FB may exacerbate hypoxaemia due to increased airway resi…
Muscle Unloading During Exercise: Comparative Effects of Conventional Oxygen, NIV and High-Flow Therapy on Neural Drive in Severe COPD Open
Objectives: To evaluate how non-invasive ventilation (NIV) and high-flow nasal can-nula therapy (HFT) versus conventional oxygen therapy (COT) affect neural ventilatory drive during exercise in patients with severe chronic obstructive pulm…
Long-Term Home Non-Invasive Ventilation in Patients with Severe COPD with Hypercapnic Respiratory Failure: Impact on Long-Term Survival, Exacerbations and Mortality Related Factors Open
The survival rate of COPD patients with hypercapnic CRF on LTH-NIV is currently high (>50% at 5 years). Adaptation to LTH-NIV in the stable phase is the most important prognostic determinant and should be considered especially in patients …
View article: ExCyTIn-Bench: Evaluating LLM agents on Cyber Threat Investigation
ExCyTIn-Bench: Evaluating LLM agents on Cyber Threat Investigation Open
We present ExCyTIn-Bench, the first benchmark to Evaluate an LLM agent x on the task of Cyber Threat Investigation through security questions derived from investigation graphs. Real-world security analysts must sift through a large number …
Prevalence and consequences of patient–ventilator interactions in a cohort of home-ventilated restrictive and neuromuscular patients: a multicentre study Open
Aims Analysis of patient–ventilator interactions in patients on chronic home mechanical ventilation can be time consuming, and the consequences of individual interaction on pulmonary gas exchange are not well understood. The objective was …
View article: Upper Airway and Translaryngeal Resistance During Mechanical Insufflation-Exsufflation
Upper Airway and Translaryngeal Resistance During Mechanical Insufflation-Exsufflation Open
We found that Ruaw and Rtl can be calculated feasibly during MI-E. The findings indicate different transmission dynamics for positive and negative pressures and that resistances are influenced by participant effort. The findings support us…
View article: Precision in Practice: Enhancing MI-E Therapy Evaluation for Improved Patient Outcomes, Excluding Speech and Swallowing. Reply to Allen et al. Comment on “Chatwin et al. Waves of Precision: A Practical Guide for Reviewing New Tools to Evaluate Mechanical In-Exsufflation Efficacy in Neuromuscular Disorders. J. Clin. Med. 2024, 13, 2643”
Precision in Practice: Enhancing MI-E Therapy Evaluation for Improved Patient Outcomes, Excluding Speech and Swallowing. Reply to Allen et al. Comment on “Chatwin et al. Waves of Precision: A Practical Guide for Reviewing New Tools to Evaluate Mechanical In-Exsufflation Efficacy in Neuromuscular Disorders. J. Clin. Med. 2024, 13, 2643” Open
We would like to thank Allen et al [...]
How do age and gender affect the respiratory pattern in healthy subjects? Open
Respiratory system monitoring can help in the early detection of diseases and potential treatment, but its response can be influenced by many factors. In this study, we analyzed the respiratory pattern variability, examining the potential …
View article: Impact of outpatient adaptation to home mechanical ventilation on health-related quality of life in patients with COPD: the OutVent study
Impact of outpatient adaptation to home mechanical ventilation on health-related quality of life in patients with COPD: the OutVent study Open
Background Home mechanical ventilation (HMV) is indicated in patients with severe hypercapnic COPD. Initiation of HMV commonly occurs during an inpatient period, but there has been increasing interest for outpatient adaptation. This study …
View article: Waves of Precision: A Practical Guide for Reviewing New Tools to Evaluate Mechanical In-Exsufflation Efficacy in Neuromuscular Disorders
Waves of Precision: A Practical Guide for Reviewing New Tools to Evaluate Mechanical In-Exsufflation Efficacy in Neuromuscular Disorders Open
Mechanical insufflation-exsufflation (MI-E) is essential for secretion clearance, especially in neuromuscular disorders. For the best outcomes, initiation of MI-E should be started at the correct time with regular evaluation to the respons…
View article: Costs and resource utilization patterns in surgical site infections: a pre-COVID-19 perspective from France, Germany, Spain, and the UK
Costs and resource utilization patterns in surgical site infections: a pre-COVID-19 perspective from France, Germany, Spain, and the UK Open
The higher rates of hospitalization, ICU admissions, and readmissions among S. aureus SSI cases highlight the severity of these infections and their impact on healthcare costs, emphasizing the potential benefits of evidence-based infection…
Feasibility and Short-Term SpO2/FiO2 Changes in Hospitalized Adults with COVID-19 Pneumonia after Chest Physiotherapy with Threshold PEP Valve: A Cross-Sectional Study Open
Background: One of the main features of COVID-19 pneumonia is hypoxemic acute respiratory failure (ARF), often requiring ventilatory support. The influence of chest physiotherapy in patients with ARF is not extensively studied. The aim of …
Effect of Chest Physiotherapy with Threshold Valve in Hospitalized Adults with COVID-19 Pneumonia Open
Background: COVID-19 pneumonia caused by SARS-Cov-2 virus induces alveolar collapse and hypoxia that may become severe. The aim of the study is to analyze the effects of chest physiotherapy using a threshold valve in patients with acute re…
View article: Impact of Early Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis: A multicenter Randomized Controlled Trial
Impact of Early Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis: A multicenter Randomized Controlled Trial Open
Background and objective: Forced vital capacity (FVC) less than 50% of predicted is one of the main parameters used for Non-Invasive Ventilation (NIV) initiation in Amyotrophic Lateral Sclerosis (ALS). Recent studies suggest that higher va…
Ventilators, Settings, Autotitration Algorithms Open
The choice of a ventilator model for a single patient is usually based on parameters such as size (portability), presence or absence of battery and ventilatory modes. However, there are many details within each ventilator model about trigg…
What Circuits, Masks and Filters Should Be Used in Home Non-Invasive Mechanical Ventilation Open
Most of the published reviews about non-invasive home ventilation mainly reflect the technical aspects of ventilators. There is much less information about the consumables most used at home. However, the choice of a good interface or tubin…
Selection of Patients for Admission to the Respiratory Intermediate Care Unit Open
The respiratory intermediate care units (RICU) usually admit patients with intermediate severity between those managed in a pulmonary ward and those admitted to the intensive care units (ICUs). There are two different assistant circuits, w…
View article: High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial
High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial Open
Rationale In patients with COVID-19 pneumonia and mild hypoxaemia, the clinical benefit of high-flow nasal oxygen (HFNO) remains unclear. We aimed to examine whether HFNO compared with conventional oxygen therapy (COT) could prevent escala…
Higher mortality and intubation rate in COVID-19 patients treated with noninvasive ventilation compared with high-flow oxygen or CPAP Open
The effectiveness of noninvasive respiratory support in severe COVID-19 patients is still controversial. We aimed to compare the outcome of patients with COVID-19 pneumonia and hypoxemic respiratory failure treated with high-flow oxygen ad…
Non-invasive Respiratory Support in COVID-19: A Narrative Review Open
Acute respiratory failure secondary to COVID-19 pneumonia may require a variety of non-pharmacological strategies in addition to oxygen therapy to avoid endotracheal intubation. The response to all these strategies, which include high nasa…
View article: Patient-Ventilator Synchronization During Non-invasive Ventilation: A Pilot Study of an Automated Analysis System
Patient-Ventilator Synchronization During Non-invasive Ventilation: A Pilot Study of an Automated Analysis System Open
Background: Patient-ventilator synchronization during non-invasive ventilation (NIV) can be assessed by visual inspection of flow and pressure waveforms but it remains time consuming and there is a large inter-rater variability, even among…