Manuel Nappi
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View article: Mild catalytic generation of CO2•− via photolysis of CO2 carbamate for hydrocarboxylation reactions
Mild catalytic generation of CO2•− via photolysis of CO2 carbamate for hydrocarboxylation reactions Open
The conversion of carbon dioxide into value-added products has emerged as an alternative method to achieve net-zero emissions. While technologies that transform CO2 into fuels and chemical feedstocks have made great strides, the direct use…
View article: Metal-free deoxygenative coupling of alcohol-derived benzoates and pyridines for small molecules and DNA-encoded libraries synthesis
Metal-free deoxygenative coupling of alcohol-derived benzoates and pyridines for small molecules and DNA-encoded libraries synthesis Open
A visible-light-mediated metal-free method for the deoxygenative coupling of alcohol-derived benzoates and pyridines. Given the mild and water-compatible conditions, small molecules and DNA headpieces are functionalized with a wide range o…
View article: Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis
Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis Open
Selective chemistry that modifies the structure of DNA and RNA is essential to understanding the role of epigenetic modifications. We report a visible-light-activated photocatalytic process that introduces a covalent modification at a C(sp…
View article: Selective Chemical Functionalization at N6 mdA Residues in DNA
Selective Chemical Functionalization at N6 mdA Residues in DNA Open
Selective chemistry that modifies the structure of DNA and RNA is essential to understanding the role of epigenetic modifications. We report a visible-light-activated photocatalytic process that introduces a covalent modification at a C(sp…
View article: Selective Chemical Functionalization at N6 mdA Residues in DNA
Selective Chemical Functionalization at N6 mdA Residues in DNA Open
Selective chemistry that modifies the structure of DNA and RNA is essential to understanding the role of epigenetic modifications. We report a visible-light-activated photocatalytic process that introduces a covalent modification at a C(sp…
View article: A Class of N–O-Type Oxidants To Access High-Valent Palladium Species
A Class of N–O-Type Oxidants To Access High-Valent Palladium Species Open
This article presents a new class of mild reagents that is capable of oxidizing palladacycle(II) complexes to high-valent palladium species, promoting the formation of C–N bonds in stoichiometric and catalytic conditions. The weak N–O bon…
View article: Selective Reductive Elimination at Alkyl Palladium(IV) by Dissociative Ligand Ionization: Catalytic C(sp<sup>3</sup>)−H Amination to Azetidines
Selective Reductive Elimination at Alkyl Palladium(IV) by Dissociative Ligand Ionization: Catalytic C(sp<sup>3</sup>)−H Amination to Azetidines Open
A palladium(II)‐catalyzed γ‐C−H amination of cyclic alkyl amines to deliver highly substituted azetidines is reported. The use of a benziodoxole tosylate oxidant in combination with AgOAc was found to be crucial for controlling a selective…
View article: Selective Reductive Elimination at Alkyl Palladium(IV) by Dissociative Ligand Ionization: Catalytic C(sp<sup>3</sup>)−H Amination to Azetidines
Selective Reductive Elimination at Alkyl Palladium(IV) by Dissociative Ligand Ionization: Catalytic C(sp<sup>3</sup>)−H Amination to Azetidines Open
A palladium(II)‐catalyzed γ‐C−H amination of cyclic alkyl amines to deliver highly substituted azetidines is reported. The use of a benziodoxole tosylate oxidant in combination with AgOAc was found to be crucial for controlling a selective…
View article: CCDC 1537951: Experimental Crystal Structure Determination
CCDC 1537951: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1537952: Experimental Crystal Structure Determination
CCDC 1537952: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1579354: Experimental Crystal Structure Determination
CCDC 1579354: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1546178: Experimental Crystal Structure Determination
CCDC 1546178: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1535492: Experimental Crystal Structure Determination
CCDC 1535492: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …