Manuel Quintana
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View article: Extracellular vesicle proteomics identifies novel blood biomarkers for the early diagnosis of status epilepticus
Extracellular vesicle proteomics identifies novel blood biomarkers for the early diagnosis of status epilepticus Open
Objective This study was undertaken to identify novel blood‐based biomarkers associated with the early diagnosis of status epilepticus (SE) by exploring proteomic alterations in plasma extracellular vesicles (EVs). Methods We conducted an …
View article: The Medical Burden of Drug‐Resistant Epilepsy in an Outpatient Clinic of a Tertiary Hospital: A Prospective Study Based on Real‐World Evidence
The Medical Burden of Drug‐Resistant Epilepsy in an Outpatient Clinic of a Tertiary Hospital: A Prospective Study Based on Real‐World Evidence Open
Objective Drug‐resistant epilepsy (DRE) leads to a range of medical and social consequences, which contribute to a high disease burden. We aimed to describe factors associated with an increased medical burden in DRE. Methods We designed a …
View article: Maternal plasma cell-free RNA as a predictor of early and late-onset preeclampsia throughout pregnancy
Maternal plasma cell-free RNA as a predictor of early and late-onset preeclampsia throughout pregnancy Open
View article: Biomarker Differences in Aneurysmal Subarachnoid Hemorrhage: A Comparative Study of Patients With and Without Delayed Cerebral Ischemia
Biomarker Differences in Aneurysmal Subarachnoid Hemorrhage: A Comparative Study of Patients With and Without Delayed Cerebral Ischemia Open
Background: Delayed cerebral ischemia (DCI) is a major cause of morbidity following aneurysmal subarachnoid hemorrhage (aSAH), yet early prediction remains challenging. This study aimed to identify blood-based protein biomarkers within 24…
View article: Identification of Plasma Growth Factors and Cytokines as Diagnostic Biomarkers for the Lafora Form of Progressive Myoclonus Epilepsy
Identification of Plasma Growth Factors and Cytokines as Diagnostic Biomarkers for the Lafora Form of Progressive Myoclonus Epilepsy Open
Lafora progressive myoclonus epilepsy (LD, OMIM#254780, ORPHA:501) is an ultra-rare and severe autosomal recessive neurological disorder that typically manifests in early adolescence. It is characterized by the accumulation of insoluble fo…
View article: Identification of Plasma Growth Factors and Cytokines as Diagnostic Biomarkers for Lafora Disease
Identification of Plasma Growth Factors and Cytokines as Diagnostic Biomarkers for Lafora Disease Open
Lafora progressive myoclonus epilepsy (LD, OMIM#254780, ORPHA:501) is an ultra-rare and severe autosomal recessive neurological disorder that typically manifests in early adolescence. It is characterized by the accumulation of insoluble fo…
View article: Immunological memory to COVID-19 vaccines in immunocompromised and immunocompetent children
Immunological memory to COVID-19 vaccines in immunocompromised and immunocompetent children Open
Background Most children in Argentina received only the initial COVID-19 vaccine series, with presumed hybrid immunity after multiple Omicron waves. However, the durability of immune memory, particularly in immunocompromised (IC) children,…
View article: 20467. IMPACTO DE LA EPILEPSIA FARMACORRESISTENTE EN LAS CONSULTAS EXTERNAS DE UN HOSPITAL TERCIARIO: UN ESTUDIO PROSPECTIVO BASADO EN LA PRÁCTICA CLÍNICA
20467. IMPACTO DE LA EPILEPSIA FARMACORRESISTENTE EN LAS CONSULTAS EXTERNAS DE UN HOSPITAL TERCIARIO: UN ESTUDIO PROSPECTIVO BASADO EN LA PRÁCTICA CLÍNICA Open
View article: 21107. IMPACTO DE LA ACTIVIDAD EPILEPTIFORME DURANTE EL SUEÑO EN EL RENDIMIENTO COGNITIVO DE LOS PACIENTES CON EPILEPSIA
21107. IMPACTO DE LA ACTIVIDAD EPILEPTIFORME DURANTE EL SUEÑO EN EL RENDIMIENTO COGNITIVO DE LOS PACIENTES CON EPILEPSIA Open
View article: 21210. TENDENCIAS ACTUALES EN EL INICIO Y EFICACIA CLÍNICA DE CENOBAMATO: EXPERIENCIA CLÍNICA
21210. TENDENCIAS ACTUALES EN EL INICIO Y EFICACIA CLÍNICA DE CENOBAMATO: EXPERIENCIA CLÍNICA Open
View article: 20562. ESTADO EPILÉPTICO EN PACIENTES CON PARADA CARDÍACA REFRACTARIA ASISTIDA MEDIANTE REANIMACIÓN CARDIOPULMONAR EXTRACORPÓREA Y FACTORES ASOCIADOS
20562. ESTADO EPILÉPTICO EN PACIENTES CON PARADA CARDÍACA REFRACTARIA ASISTIDA MEDIANTE REANIMACIÓN CARDIOPULMONAR EXTRACORPÓREA Y FACTORES ASOCIADOS Open
View article: Identifying risk for status epilepticus with the ADAN scale: a prospective multicenter validation study
Identifying risk for status epilepticus with the ADAN scale: a prospective multicenter validation study Open
Objetivo. El estado epiléptico (EE) es una enfermedad grave con elevada mortalidad. Este estudio tiene como objetivo validar la escala ADAN, propuesta recientemente para identificar pacientes con alto riesgo de desarrollar un EE. Método. S…
View article: Exploratory study of blood biomarkers in patients with post-stroke epilepsy
Exploratory study of blood biomarkers in patients with post-stroke epilepsy Open
Introduction: In addition to clinical factors, blood-based biomarkers can provide useful information on the risk of developing post-stroke epilepsy (PSE). Our aim was to identify serum biomarkers at stroke onset that could contribute to pr…
View article: Safety and efficacy of early carotid artery stenting in patients with symptomatic stenosis
Safety and efficacy of early carotid artery stenting in patients with symptomatic stenosis Open
Background Symptomatic carotid artery stenosis is a significant contributor to ischemic strokes. Carotid artery stenting (CAS) is usually indicated for secondary stroke prevention. This study evaluates the safety and efficacy of CAS perfor…
View article: Riesgo de epilepsia tras una primera crisis epiléptica de etiología desconocida en pacientes de edad avanzada
Riesgo de epilepsia tras una primera crisis epiléptica de etiología desconocida en pacientes de edad avanzada Open
The risk of epilepsy in the long term following a single seizure of unknown etiology in elderly patients is greater than 80%. Arterial hypertension and mild cognitive impairment at baseline are the most common clinical features. Cortical a…
View article: Gait Assessment in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Gait Assessment in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Open
Background and Aims . Gait impairment is a common manifestation of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, clinicians lack an effective monitoring tool, as no gait test has been validated for CIDP. The ai…
View article: Efficacy of Perampanel in Nocturnal Seizures in Adult Patients with Epilepsy
Efficacy of Perampanel in Nocturnal Seizures in Adult Patients with Epilepsy Open
Objective . Nocturnal seizures are usually underestimated and represent a major problem in adult patients with epilepsy. Our aim was to study the effectiveness of perampanel for the treatment of nocturnal seizures in adult patients with ep…
View article: Real-Life Effectiveness and Tolerability of Brivaracetam in Focal to Bilateral and Primary Generalized Tonic-Clonic Seizures
Real-Life Effectiveness and Tolerability of Brivaracetam in Focal to Bilateral and Primary Generalized Tonic-Clonic Seizures Open
Purpose. Brivaracetam (BRV), an antiseizure medication indicated for focal-onset seizures, has shown efficacy in the treatment of focal to bilateral tonic-clonic seizures (FBTCS). We aimed to determine the effectiveness and safety of BRV i…
View article: Implications of starting antiepileptic treatment prior to electroencephalography in first epileptic seizures
Implications of starting antiepileptic treatment prior to electroencephalography in first epileptic seizures Open
Administration of AEDs before an early EEG following a first seizure does not decrease the likelihood of detecting epileptiform abnormalities. These findings suggest that starting AED treatment immediately in patients with a high risk of e…
View article: Wall enhancement as a biomarker of intracranial aneurysm instability: a histo-radiological study
Wall enhancement as a biomarker of intracranial aneurysm instability: a histo-radiological study Open
View article: Multidisciplinary consensus document on the management of massive haemorrhage. First update 2023 (document HEMOMAS-II)
Multidisciplinary consensus document on the management of massive haemorrhage. First update 2023 (document HEMOMAS-II) Open
View article: Multidisciplinary consensus document on the management of massive haemorrhage. First update 2023 (document HEMOMAS-II)
Multidisciplinary consensus document on the management of massive haemorrhage. First update 2023 (document HEMOMAS-II) Open
View article: Erratum to “Nasal cannula use during polysomnography in children aged under three with suspected sleep apnea” [Sleep Med 99 (2022) 41–48 5332]
Erratum to “Nasal cannula use during polysomnography in children aged under three with suspected sleep apnea” [Sleep Med 99 (2022) 41–48 5332] Open
View article: End‐tidal and transcutaneous CO<sub>2</sub> monitoring during sleep in children aged under three with suspected sleep apnea
End‐tidal and transcutaneous CO<sub>2</sub> monitoring during sleep in children aged under three with suspected sleep apnea Open
Obstructive sleep apnea (OSA) is increasingly being recognized in children, with an estimated prevalence between 1% and 5%. Untreated OSA in children is associated with neurobehavioral, cardiovascular, growth, and metabolic abnormalities. …
View article: Indications and hemoglobin thresholds for red blood cell transfusion and iron replacement in adults with gastrointestinal bleeding: An algorithm proposed by gastroenterologists and patient blood management experts
Indications and hemoglobin thresholds for red blood cell transfusion and iron replacement in adults with gastrointestinal bleeding: An algorithm proposed by gastroenterologists and patient blood management experts Open
Gastrointestinal (GI) bleeding is associated with considerable morbidity and mortality. Red blood cell (RBC) transfusion has long been the cornerstone of treatment for anemia due to GI bleeding. However, blood is not devoid of potential ad…
View article: Nasal cannula use during polysomnography in children aged under three with suspected sleep apnea
Nasal cannula use during polysomnography in children aged under three with suspected sleep apnea Open
View article: Relationship between visuoperceptual functions and parietal structural abnormalities in temporal lobe epilepsy
Relationship between visuoperceptual functions and parietal structural abnormalities in temporal lobe epilepsy Open
Purpose: Progressive gray matter volume reductions beyond the epileptogenic area has been described in temporal lobe epilepsy. There is less evidence regarding correlations between gray and white matter volume changes and multi-domain cogn…
View article: Epileptic seizures in the emergency room: clinical and electroencephalographic findings associated with brain perfusion patterns on computed tomography
Epileptic seizures in the emergency room: clinical and electroencephalographic findings associated with brain perfusion patterns on computed tomography Open
View article: Functional Recovery and Serum Angiogenin Changes According to Intensity of Rehabilitation Therapy After Stroke
Functional Recovery and Serum Angiogenin Changes According to Intensity of Rehabilitation Therapy After Stroke Open
Background: Rehabilitation is still the only treatment available to improve functional status after the acute phase of stroke. Most clinical guidelines highlight the need to design rehabilitation treatments considering starting time, inten…
View article: SEDAR-SEMICYUC consensus on the management of haemostasis disorders in severe COVID-19 patients
SEDAR-SEMICYUC consensus on the management of haemostasis disorders in severe COVID-19 patients Open