Manuela Arbune
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View article: Dynamics of Anxiety, Depression, and Sleep Quality Following COVID-19 Hospitalization in Romania
Dynamics of Anxiety, Depression, and Sleep Quality Following COVID-19 Hospitalization in Romania Open
Background: COVID-19 has been associated with neurological and psychiatric manifestations, both at disease onset and during post-infectious sequelae, such as anxiety, depression, and sleep disturbances. Previous pandemics suggest potential…
View article: CAR-T Cell Therapy for HIV Cure: Current Challenges, Advances and Future Directions
CAR-T Cell Therapy for HIV Cure: Current Challenges, Advances and Future Directions Open
Antiretroviral therapy (ART) effectively suppresses HIV replication but fails to eradicate latent reservoirs, leading to viral rebound after interruption. Chimeric antigen receptor (CAR) T-cell therapy offers a potential strategy to achiev…
View article: Triple Burden of HIV, HBV and HDV in Adults with Childhood Parenterally Acquired Infections: A Romanian Single-Center Study
Triple Burden of HIV, HBV and HDV in Adults with Childhood Parenterally Acquired Infections: A Romanian Single-Center Study Open
Background: Co-infections with HIV, HBV, and HDV pose significant public health challenges, especially in populations exposed parenterally. Romania hosts a unique pediatric HIV cohort of individuals born 1987–1995 who acquired HIV iatrogen…
View article: Perception Versus Actual Weight: Body Image Dissatisfaction as a Stronger Correlate of Anxiety and Depression than BMI Among Romanian Health Sciences Students
Perception Versus Actual Weight: Body Image Dissatisfaction as a Stronger Correlate of Anxiety and Depression than BMI Among Romanian Health Sciences Students Open
Background: The high prevalence of anxiety and depression among young adults constitutes a significant public health concern, with body image identified as a key psychological factor. However, the interplay between subjective metrics (perc…
View article: Digital Media Habits and Depressive Symptoms in Romanian Health Sciences Students: A Focused Pilot Study on Social Media Use and Gaming Time
Digital Media Habits and Depressive Symptoms in Romanian Health Sciences Students: A Focused Pilot Study on Social Media Use and Gaming Time Open
This focused pilot study aimed to explore specific associations between key digital media habits, namely, time spent on social media applications and video gaming, and the severity of depressive symptoms among undergraduate medical and nur…
View article: Cardiovascular Risk in People Living with HIV: A Preliminary Case Study from Romania
Cardiovascular Risk in People Living with HIV: A Preliminary Case Study from Romania Open
Background and Objectives: AIDS-related mortality has significantly decreased due to antiretroviral therapy (ART), leading to a substantial increase in average lifespan. Consequently, cardiovascular diseases have become a growing concern a…
View article: Factors Associated with Burnout in Medical Students: An Exploration of Demographic, Academic, and Psychological Variables
Factors Associated with Burnout in Medical Students: An Exploration of Demographic, Academic, and Psychological Variables Open
Background: This study investigated the prevalence and predictors of burnout among medical students at “Dunărea de Jos” University of Galați, Faculty of Medicine and Pharmacy. Methods: Burnout was measured using the School Burnout Inventor…
View article: Retrospective analysis of HIV-associated lymphomas: insights from a single Romanian center over 15 years
Retrospective analysis of HIV-associated lymphomas: insights from a single Romanian center over 15 years Open
Introduction Lymphoma is a significant cause of mortality among people living with human immunodeficiency virus (PLWH). The objective of our study was to assess the characteristics of lymphomas in PLWH in a single center from the southeast…
View article: Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from Romania
Prognostic Value of the Brixia Radiological Score in COVID-19 Patients: A Retrospective Study from Romania Open
The novel coronavirus pandemic, SARS-CoV-2, has a variable clinical spectrum, ranging from asymptomatic to critical forms. High mortality and morbidity rates have been associated with risk factors such as comorbidities, age, sex, and virul…
View article: Dynamics of Clinical, Radiological, and Biological Expression in Hospitalised COVID-19 Patients and Post-Infectious Mortality: Comparison Between 2024 and 2020
Dynamics of Clinical, Radiological, and Biological Expression in Hospitalised COVID-19 Patients and Post-Infectious Mortality: Comparison Between 2024 and 2020 Open
Clinical manifestations and mortality caused by SARS-CoV-2 change, consistent with circulating viral variants and population immunity. Our retrospective study analyses the hospitalised COVID-19 cases from Romania in 2024 comparative with 2…
View article: Obesity and Cardiovascular Risk in Romanian HIV Patients: Real-World Evidence
Obesity and Cardiovascular Risk in Romanian HIV Patients: Real-World Evidence Open
Mortality among people with HIV undergoing antiretroviral treatment (ART) has decreased, but non-AIDS-related causes of death, including cardiovascular and metabolic diseases, have risen. We conducted a cross-sectional study on 112 HIV-ser…
View article: Dynamics of Clinical, Radiological, and Biological Expression In Hospitalized COVID-19 Patients and Post-infectious Mortality: Comparison between 2024 and 2020
Dynamics of Clinical, Radiological, and Biological Expression In Hospitalized COVID-19 Patients and Post-infectious Mortality: Comparison between 2024 and 2020 Open
Clinical manifestations and mortality caused by SARS-CoV-2 change, consistent with circulating viral variants and population immunity. Our retrospective study analyses the hospitalized COVID-19 cases from Romania in 2024 comparative with 2…
View article: Managing HIV-Associated Hodgkin Lymphoma During the COVID-19 Pandemic: Case Report and Literature Review
Managing HIV-Associated Hodgkin Lymphoma During the COVID-19 Pandemic: Case Report and Literature Review Open
The COVID-19 pandemic delayed the consultation of many patients with specialists. We present the case of a 57-year-old patient with HIV infection, COVID-19 pneumonia, and Hodgkin lymphoma. Discordant immunohistochemistry results from biops…
View article: Echocardiographic Left Ventricular Function in the Third Year After COVID-19 Hospitalization: A Follow-Up Pilot Study in South-East of Romania
Echocardiographic Left Ventricular Function in the Third Year After COVID-19 Hospitalization: A Follow-Up Pilot Study in South-East of Romania Open
Background and Objectives: Cardiac involvement in COVID-19 has been confirmed during the acute stage of the infection. However, the prevalence and spectrum of post-infectious cardiac dysfunction remain incompletely clarified. The objective…
View article: Multidrug-resistant ESKAPE Pathogens in a Romanian Secondary-Care Hospital during the COVID-19 Pandemic
Multidrug-resistant ESKAPE Pathogens in a Romanian Secondary-Care Hospital during the COVID-19 Pandemic Open
The study aims to assess the frequency of ESKAPE pathogens and their antimicrobial resistance profile during the COVID-19 pandemic in a multidisciplinary hospital. Based on microbiological reports, the present study retrospectively evaluat…
View article: Lymphomas and Human Immunodeficiency Virus: Insights from a 15-Year Retrospective Romanian Study
Lymphomas and Human Immunodeficiency Virus: Insights from a 15-Year Retrospective Romanian Study Open
Lymphoma is a significant cause of mortality among people living with human immunodeficiency virus (PLWH). This retrospective study analyzes the prevalence, mortality and clinical-demographic characteristics of patients with lymphoma assoc…
View article: Basal Cell Carcinoma Cleft: The Missing Piece of the Puzzle
Basal Cell Carcinoma Cleft: The Missing Piece of the Puzzle Open
The BCC tumor islands were found to have a minimal approximately equal measurement to the tumor-stroma separation cleft, but they were always larger than the latter. Large clefts and their respective tumor islands were found in specific tu…
View article: An Epidemiological Perspective on New Pediatric Cases of Type 1 Diabetes and Vitamin D Deficiency in South-East Romania: A Retrospective Study
An Epidemiological Perspective on New Pediatric Cases of Type 1 Diabetes and Vitamin D Deficiency in South-East Romania: A Retrospective Study Open
Objectives: The aim of this study is to analyze the epidemiological characteristics and the biological profile of children from the southeast of Romania who have been newly diagnosed with type 1 diabetes (T1DM) and to investigate the poten…
View article: Comparative Epidemiological and Clinical Outcomes on COVID-19 and Seasonal Influenza Hospitalized Patients during 2023
Comparative Epidemiological and Clinical Outcomes on COVID-19 and Seasonal Influenza Hospitalized Patients during 2023 Open
COVID-19 and influenza are highly contagious respiratory viral diseases and priority global public health concerns. We conducted a retrospective observational study of COVID-19 and/or influenza hospitalized cases, during 2023. We identifie…
View article: Obstructive Sleep Apnea after COVID-19: An Observational Study
Obstructive Sleep Apnea after COVID-19: An Observational Study Open
The risk factors of hospitalized COVID-19 and obstructive sleep apnea (OSA) overlap. The aim of this study is to evaluate the prevalence and associated factors of post-COVID-19 OSA in hospitalized adult patients from southeastern Romania. …
View article: Multidisciplinary Perspectives of Challenges in Infective Endocarditis Complicated by Septic Embolic-Induced Acute Myocardial Infarction
Multidisciplinary Perspectives of Challenges in Infective Endocarditis Complicated by Septic Embolic-Induced Acute Myocardial Infarction Open
Background: Infective endocarditis (IE) management is challenging, usually requiring multidisciplinary collaboration from cardiologists, infectious disease specialists, interventional cardiologists, and cardiovascular surgeons, as more tha…
View article: Prevalence of multidrug resistance pathogens in dermatology: A retrospective study in Romania, 2018-2022
Prevalence of multidrug resistance pathogens in dermatology: A retrospective study in Romania, 2018-2022 Open
Antimicrobial resistance (AMR) is now a major challenge to clinicians in treating patients. The purpose of our study was to determine the incidence of multidrug resistant (MDR) strains and antibiotic resistance profile in department of der…
View article: The Impact of COVID-19 on the Tuberculosis Features in a Romanian Pneumology Hospital
The Impact of COVID-19 on the Tuberculosis Features in a Romanian Pneumology Hospital Open
The co-infection of COVID-19 had a mild impact on the clinical and biological expression of tuberculosis diagnosed in a pandemic context.
View article: Unusual Localization of AIDS-Related Kaposi’s Sarcoma in a Heterosexual Male during the COVID-19 Pandemic: A Case Report
Unusual Localization of AIDS-Related Kaposi’s Sarcoma in a Heterosexual Male during the COVID-19 Pandemic: A Case Report Open
Kaposi’s sarcoma is an AIDS-defining illness and remains the most frequent tumor arising in HIV-infected patients with multifactorial etiology. We present a case of a 30-year-old Caucasian male with an 18-year history of HIV infection. The…
View article: The Impact of COVID-19 on the Tuberculosis Outcomes in a Pneumology Hospital from South-East Romania
The Impact of COVID-19 on the Tuberculosis Outcomes in a Pneumology Hospital from South-East Romania Open
The COVID-19 pandemic and tuberculosis have epidemiological similarities, being transmitted airborne, favored by direct contact, crowded environments and vulnerable biological status. We performed a retrospective study of 45 cases of pulmo…
View article: Multidrug-Resistant ESKAPE Pathogens in a Romanian Secondary-Care Hospital during the COVID-19 Pandemic
Multidrug-Resistant ESKAPE Pathogens in a Romanian Secondary-Care Hospital during the COVID-19 Pandemic Open
The ESKAPE pathogens are public health concerns worldwide, defining the present major antibiotic resistance issues: E. faecium vancomycin-R, S. aureus methicillin-R, Ps. Aeruginosa and A. baumannii carbapenem-R, resistance to 3rd generatio…
View article: Cognitive Dysfunction in Hospitalized Patient with Moderate-to-Severe COVID-19: A 1-Year Prospective Observational Study
Cognitive Dysfunction in Hospitalized Patient with Moderate-to-Severe COVID-19: A 1-Year Prospective Observational Study Open
Cognitive domain impairments related to COVID-19 could persist over 6 months post-acute infectious episode requiring systematic screening for early diagnosis of progressive brain pathologies and rehabilitation.
View article: Vulvovaginal Candidiasis in Pregnancy—Between Sensitivity and Resistance to Antimycotics
Vulvovaginal Candidiasis in Pregnancy—Between Sensitivity and Resistance to Antimycotics Open
Vulvovaginitis with Candida spp. is the most common infection in women and the rate is increased during pregnancy. Antifungal prescription in pregnant women continues to present challenges and the decision must balance the risk of fetal to…
View article: Meningo encephalitis with Epstein-Barr virus in an immunocompetent adult patient: case report
Meningo encephalitis with Epstein-Barr virus in an immunocompetent adult patient: case report Open
Epstein-Barr virus is a rare ethology of the neurological infections, expressed as encephalitis, aseptic meningitis, Guillain-Barre syndrome or acute demyelinating encephalomyelitis. Most common cases were reported in children, while this …
View article: Ulceration and a White Lesion of the Tongue in a Male HIV Positive Patient: A Journey on the Avenue of Differential Diagnoses in Search of a Solution
Ulceration and a White Lesion of the Tongue in a Male HIV Positive Patient: A Journey on the Avenue of Differential Diagnoses in Search of a Solution Open
Oral lesions are early indicator of immunosuppression, leading to HIV new diagnoses. The type of oral lesions can reveal opportunistic diseases that are correlated with the severity of immune depletion. Highly active antiretroviral therapy…