Michael L. Ganz
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View article: A dose of doubt: a qualitative study on placebo regulations
A dose of doubt: a qualitative study on placebo regulations Open
Introduction Placebo use is common in primary care, yet ethical and legal concerns persist, and few qualitative studies have explored physicians’ views on placebo regulation. Methods We conducted semi-structured interviews with 10 primary …
View article: Meningococcal vaccination disparities in the United States (2010–2021): Findings from the National Immunization Survey-Teen and a commercial insurance database
Meningococcal vaccination disparities in the United States (2010–2021): Findings from the National Immunization Survey-Teen and a commercial insurance database Open
In the United States, while meningococcal vaccines are available and recommended for adolescents and young adults, coverage remains low and disparities persist. We evaluated meningococcal serogroups A, C, W, Y (MenACWY) and B (MenB) vaccin…
View article: Noble Humbug? Hard and soft laws on clinical placebo use
Noble Humbug? Hard and soft laws on clinical placebo use Open
Despite the widespread historical and contemporary use of placebos in medicine, legal regulations addressing their administration remain limited in many countries. This paper examines the legal landscape of clinical placebo use, focusing o…
View article: Retrospective analysis of health and economic burden among commercially-insured individuals diagnosed with invasive meningococcal disease in the United States
Retrospective analysis of health and economic burden among commercially-insured individuals diagnosed with invasive meningococcal disease in the United States Open
Invasive meningococcal disease (IMD) is a life-threatening yet vaccine-preventable disease, with vaccines approved and recommended in the United States by the Centers for Disease Control and Prevention. This study assessed complications, m…
View article: Healthcare resource utilisation and direct medical cost for individuals with 5q spinal muscular atrophy in Sweden
Healthcare resource utilisation and direct medical cost for individuals with 5q spinal muscular atrophy in Sweden Open
Background Spinal muscular atrophy (SMA) is a rare, progressive, neuromuscular disorder. Recent advances in treatment require an updated assessment of burden to inform reimbursement decisions. Objectives To quantify healthcare resource uti…
View article: Corrigendum: Real-World Treatment Patterns of Antiviral Prophylaxis for Cytomegalovirus Among Adult Kidney Transplant Recipients: A Linked USRDS-Medicare Database Study
Corrigendum: Real-World Treatment Patterns of Antiviral Prophylaxis for Cytomegalovirus Among Adult Kidney Transplant Recipients: A Linked USRDS-Medicare Database Study Open
Graphical Abstract
View article: Factors Associated With Treatment Escalation for Psoriasis: An Analysis of Electronic Health Records Data
Factors Associated With Treatment Escalation for Psoriasis: An Analysis of Electronic Health Records Data Open
Background Electronic health records (EHRs) offer the possibility of using data entry templates to simultaneously document routine clinical care and capture disease-specific measures as discrete data elements that can be used for health se…
View article: Estimating Changes in Weight and Metabolic Parameters Before and After Treatment With Cariprazine: A Retrospective Study of Electronic Health Records
Estimating Changes in Weight and Metabolic Parameters Before and After Treatment With Cariprazine: A Retrospective Study of Electronic Health Records Open
These real-world results support short-term clinical trial findings describing a neutral weight and metabolic profile associated with cariprazine treatment and they expand the dataset to include long-term follow-up.
View article: 1143. Meningococcal Vaccination Coverage Disparities in the United States: An Analysis with 2016-2021 National Immunization Survey-Teen Data
1143. Meningococcal Vaccination Coverage Disparities in the United States: An Analysis with 2016-2021 National Immunization Survey-Teen Data Open
Background The US Advisory Committee on Immunization Practices recommends meningococcal vaccination against serogroups A, C, W, and Y (MenACWY) for 11–12 year-olds (y/o) with a booster at 16; and against serogroup B (MenB) for 16–23 y/o un…
View article: Use and Cost of Healthcare Services Among Patients with Moderate-to-Severe Osteoarthritis of Hip/Knee with Inadequate Analgesia: Findings from two United States Health Systems
Use and Cost of Healthcare Services Among Patients with Moderate-to-Severe Osteoarthritis of Hip/Knee with Inadequate Analgesia: Findings from two United States Health Systems Open
Background Accurate estimates of costs specific to persons with moderate-to-severe hip and/or knee osteoarthritis who experience inadequate analgesia are difficult to obtain, and are likely to be substantial. To address this issue, this st…
View article: Use of electronic health data to identify patients with moderate-to-severe osteoarthritis of the hip and/or knee and inadequate response to pain medications
Use of electronic health data to identify patients with moderate-to-severe osteoarthritis of the hip and/or knee and inadequate response to pain medications Open
Background No algorithms exist to identify important osteoarthritis (OA) patient subgroups (i.e., moderate-to-severe disease, inadequate response to pain treatments) in electronic healthcare data, possibly due to the complexity in defining…
View article: Healthcare Service Use Patterns Among Patients with Acid Sphingomyelinase Deficiency Type B: A Retrospective US Claims Analysis
Healthcare Service Use Patterns Among Patients with Acid Sphingomyelinase Deficiency Type B: A Retrospective US Claims Analysis Open
This retrospective analysis of medical claims data identified patients with ASMD type B who had characteristics typical of this condition. A machine-learning algorithm detected further cases with a high probability of having ASMD type B. H…
View article: Real-World Treatment Patterns of Antiviral Prophylaxis for Cytomegalovirus Among Adult Kidney Transplant Recipients: A Linked USRDS-Medicare Database Study
Real-World Treatment Patterns of Antiviral Prophylaxis for Cytomegalovirus Among Adult Kidney Transplant Recipients: A Linked USRDS-Medicare Database Study Open
Limited data exist on cytomegalovirus (CMV) antiviral treatment patterns among kidney transplant recipients (KTRs). Using United States Renal Database System registry data and Medicare claims (1 January 2011–31 December 2017), we examined …
View article: Factors Associated with Treatment Escalation for Psoriasis: an Electronic Health Record Platform for Retrospective and Prospective Real-world Studies
Factors Associated with Treatment Escalation for Psoriasis: an Electronic Health Record Platform for Retrospective and Prospective Real-world Studies Open
Background Electronic health records (EHRs) offer the possibility of using data entry templates to simultaneously perform routine documentation during clinical care and to capture disease-specific measures as discrete data elements that ca…
View article: 1378. Impact of Cytomegalovirus Prophylaxis on Clinical Outcomes in Kidney Transplantation: A United States Renal Data System-Medicare Linked Database Study
1378. Impact of Cytomegalovirus Prophylaxis on Clinical Outcomes in Kidney Transplantation: A United States Renal Data System-Medicare Linked Database Study Open
Background Guidelines recommends cytomegalovirus (CMV) prophylaxis by CMV serostatus/risk status, as the currently available antiviral agents may lead to myelosuppressive events in kidney transplant recipients (KTRs). Limited data exist fo…
View article: 1387. Impact of Cytomegalovirus Prophylaxis on Healthcare Resource Use and Costs among Kidney Transplant Recipients: A United States Renal Data System-Medicare Linked Database Study
1387. Impact of Cytomegalovirus Prophylaxis on Healthcare Resource Use and Costs among Kidney Transplant Recipients: A United States Renal Data System-Medicare Linked Database Study Open
Background Cytomegalovirus (CMV) management requires a balance between reducing the risk of CMV infection and avoiding anti-viral toxicities. Limited information is available on the impact of CMV prophylaxis on the healthcare resource use …
View article: In Reply to Xue W, Ribalov R, Zhou Z-Y, et al. Re: Ganz ML, Chavan A, Dhanda R, et al. Cost-effectiveness of valbenazine compared with deutetrabenazine for the treatment of tardive dyskinesia. J Med Econ. 2021;24(1):103–113
In Reply to Xue W, Ribalov R, Zhou Z-Y, et al. Re: Ganz ML, Chavan A, Dhanda R, et al. Cost-effectiveness of valbenazine compared with deutetrabenazine for the treatment of tardive dyskinesia. J Med Econ. 2021;24(1):103–113 Open
This article refers to:Cost-effectiveness of valbenazine compared with deutetrabenazine for the treatment of tardive dyskinesiaThis article is related to:Re: Ganz ML, Chavan A, Dhanda R, et al. Cost-effectiveness of valbenazine compared wi…
View article: Cost-effectiveness of valbenazine compared with deutetrabenazine for the treatment of tardive dyskinesia
Cost-effectiveness of valbenazine compared with deutetrabenazine for the treatment of tardive dyskinesia Open
In patients with TD, treatment with valbenazine is highly cost-effective compared with deutetrabenazine.
View article: Healthcare resource utilization and cost among patients with type 1 diabetes in the United States
Healthcare resource utilization and cost among patients with type 1 diabetes in the United States Open
BACKGROUND: Approximately 5%-10% of patients with diabetes are diagnosed with type 1 diabetes mellitus (T1DM), the incidence and prevalence of which is projected to increase through 2050. Despite this, T1DM-related health care resource uti…
View article: Association of the US Food and Drug Administration Antipsychotic Drug Boxed Warning With Medication Use and Health Outcomes in Elderly Patients With Dementia
Association of the US Food and Drug Administration Antipsychotic Drug Boxed Warning With Medication Use and Health Outcomes in Elderly Patients With Dementia Open
These data suggest that the 2005 FDA boxed warning was associated with some unintended negative patient outcomes.
View article: Retrospective Cohort Analysis of the Reduced Burden of Hypoglycemia Associated with Dipeptidyl Peptidase-4 Inhibitor Use in Patients with Type 2 Diabetes Mellitus
Retrospective Cohort Analysis of the Reduced Burden of Hypoglycemia Associated with Dipeptidyl Peptidase-4 Inhibitor Use in Patients with Type 2 Diabetes Mellitus Open
Merck & Co., Inc., Kenilworth, NJ USA.
View article: Economic burden of hospital admissions for patients with acute bacterial skin and skin structure infections in the United States
Economic burden of hospital admissions for patients with acute bacterial skin and skin structure infections in the United States Open
Objectives: We estimated the total US hospital costs associated with acute bacterial skin and skin structure infection (ABSSSI) admissions as well as the admissions that may have been potential candidates for outpatient parenteral antimicr…
View article: The Effects of a Sitagliptin Formulary Restriction Program on Diabetes Medication Use.
The Effects of a Sitagliptin Formulary Restriction Program on Diabetes Medication Use. Open
The step therapy program changed patients' use of sitagliptin, which was the target of the step therapy program, as well as of other antidiabetes medications. Most patients stopped sitagliptin treatment after the step therapy program start…
View article: A new framework for evaluating the health impacts of treatment for Gaucher disease type 1
A new framework for evaluating the health impacts of treatment for Gaucher disease type 1 Open
NCT01136304 . Registered: May 31, 2010 (retrospectively registered).
View article: Comparing Healthcare Costs Associated with Oral and Subcutaneous Methotrexate or Biologic Therapy for Rheumatoid Arthritis in the United States.
Comparing Healthcare Costs Associated with Oral and Subcutaneous Methotrexate or Biologic Therapy for Rheumatoid Arthritis in the United States. Open
Our findings that patients who switched to subcutaneous MTX incurred lower costs than patients who only used oral MTX before using biologics may provide useful information for patients and providers who are choosing between continued MTX u…
View article: The Economic and Health-related Impact of Crohnʼs Disease in the United States
The Economic and Health-related Impact of Crohnʼs Disease in the United States Open
CD is responsible for increased medical care costs and lower earnings, health status, and HRQOL. These data can serve as benchmarks when examining future CD-related costs and HRQOL.
View article: THC volume 32 issue 6 Cover and Front matter
THC volume 32 issue 6 Cover and Front matter Open
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