Manuela Estermann
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View article: A 3D multi-cellular tissue model of the human omentum to study the formation of ovarian cancer metastasis
A 3D multi-cellular tissue model of the human omentum to study the formation of ovarian cancer metastasis Open
Reliable and predictive experimental models are urgently needed to study metastatic mechanisms of ovarian cancer cells in the omentum. Although models for ovarian cancer cell adhesion and invasion were previously investigated, the lack of …
View article: Design of Perfused PTFE Vessel‐Like Constructs for In Vitro Applications
Design of Perfused PTFE Vessel‐Like Constructs for In Vitro Applications Open
Tissue models mimic the complex 3D structure of human tissues, which allows the study of pathologies and the development of new therapeutic strategies. The introduction of perfusion overcomes the diffusion limitation and enables the format…
View article: A 3D multi-cellular tissue model of the human omentum to study mechanisms of ovarian cancer metastasis
A 3D multi-cellular tissue model of the human omentum to study mechanisms of ovarian cancer metastasis Open
Here, the design of 3D multi-cellular tissue model of the human omentum is presented to study mechanisms of ovarian cancer metastasis.
View article: Design of perfused PTFE vessel-like constructs for in vitro applications
Design of perfused PTFE vessel-like constructs for in vitro applications Open
The design of a vessel-like construct for further use in perfused tissue models using PTFE membranes and collagen is presented. Endothelial cells were able to adhere to the tube’s wall, resisted perfusion, and formed an endothelial barrier…
View article: Design of perfused PTFE vessel-like constructs for in vitro applications
Design of perfused PTFE vessel-like constructs for in vitro applications Open
The design of a vessel-like construct for further use in perfused tissue models using PTFE membranes and collagen is presented. Endothelial cells were able to adhere to the tube’s wall, resisted perfusion, and formed an endothelial barrier…
View article: A 3D multi-cellular tissue model of the human omentum to study mechanisms of ovarian cancer metastasis
A 3D multi-cellular tissue model of the human omentum to study mechanisms of ovarian cancer metastasis Open
Here, the design of 3D multi-cellular tissue model of the human omentum is presented to study mechanisms of ovarian cancer metastasis.
View article: Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion
Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion Open
The presence of ascites in the peritoneal cavity leads to morphological and functional changes of the peritoneal mesothelial cell layer. Cells loose cell-cell interactions, rearrange their cytoskeleton, activate the production of fibronect…
View article: Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis Open
The extracellular matrix (ECM) plays critical roles in tumor progression and metastasis. However, the contribution of ECM proteins to early metastatic onset in the peritoneal cavity remains unexplored. Here, we suggest a new route of metas…
View article: Author response: Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
Author response: Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The extracellular matrix (ECM) plays criti…
View article: Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion
Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion Open
Raw data of "Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion".
View article: Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion
Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion Open
Raw data of "Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion".
View article: Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion
Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion Open
Raw data of "Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion".
View article: Polydopamine/Transferrin Hybrid Nanoparticles for Targeted Cell-Killing
Polydopamine/Transferrin Hybrid Nanoparticles for Targeted Cell-Killing Open
Polydopamine can form biocompatible particles that convert light into heat. Recently, a protocol has been optimized to synthesize polydopamine/protein hybrid nanoparticles that retain the biological function of proteins, and combine it wit…