Manuela J. Rist
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View article: The HuMet Repository: Watching human metabolism at work
The HuMet Repository: Watching human metabolism at work Open
View article: Dietary Assessment of Plant Food Intake Using Multi-Biomarker Panels
Dietary Assessment of Plant Food Intake Using Multi-Biomarker Panels Open
This abstract introduces the ongoing project “PlantIntake” and the accompanying validation study that will start in January 2024—current status and goals will be presented at the conference. PlantIntake, a JPI-funded project,…
View article: A new statistical workflow (R-packages based) to investigate associations between one variable of interest and the metabolome
A new statistical workflow (R-packages based) to investigate associations between one variable of interest and the metabolome Open
Introduction In metabolomics, the investigation of associations between the metabolome and one trait of interest is a key research question. However, statistical analyses of such associations are often challenging. Statistical tools enabli…
View article: The HuMet Repository: Watching human metabolism at work
The HuMet Repository: Watching human metabolism at work Open
The human metabolism constantly responds to stimuli such as food intake, fasting, exercise, and stress, triggering adaptive biochemical processes across multiple metabolic pathways. To understand the role of these processes and disruptions…
View article: Acute effects of moderate vs. vigorous endurance exercise on urinary metabolites in healthy, young, physically active men—A multi-platform metabolomics approach
Acute effects of moderate vs. vigorous endurance exercise on urinary metabolites in healthy, young, physically active men—A multi-platform metabolomics approach Open
Introduction: Endurance exercise alters whole-body as well as skeletal muscle metabolism and physiology, leading to improvements in performance and health. However, biological mechanisms underlying the body’s adaptations to different endur…
View article: Dynamic patterns of postprandial metabolic responses to three dietary challenges
Dynamic patterns of postprandial metabolic responses to three dietary challenges Open
Food intake triggers extensive changes in the blood metabolome. The kinetics of these changes depend on meal composition and on intrinsic, health-related characteristics of each individual, making the assessment of changes in the postprand…
View article: Dynamics and determinants of human plasma bile acid profiles during dietary challenges
Dynamics and determinants of human plasma bile acid profiles during dietary challenges Open
In recent years, bile acids (BA) have received great interest due to their pleiotropic biological activity and the presence of plasma membrane-bound and nuclear receptors. Moreover, BA in blood have been identified by metabolite screening …
View article: Sex-Specific Relationship between the Cardiorespiratory Fitness and Plasma Metabolite Patterns in Healthy Humans—Results of the KarMeN Study
Sex-Specific Relationship between the Cardiorespiratory Fitness and Plasma Metabolite Patterns in Healthy Humans—Results of the KarMeN Study Open
Cardiorespiratory fitness (CRF) represents a strong predictor of all-cause mortality and is strongly influenced by regular physical activity (PA). However, the biological mechanisms involved in the body’s adaptation to PA remain to be full…
View article: An NMR-Based Approach to Identify Urinary Metabolites Associated with Acute Physical Exercise and Cardiorespiratory Fitness in Healthy Humans—Results of the KarMeN Study
An NMR-Based Approach to Identify Urinary Metabolites Associated with Acute Physical Exercise and Cardiorespiratory Fitness in Healthy Humans—Results of the KarMeN Study Open
Knowledge on metabolites distinguishing the metabolic response to acute physical exercise between fit and less fit individuals could clarify mechanisms and metabolic pathways contributing to the beneficial adaptations to exercise. By analy…
View article: Associations of Diet and Plasma BCAA Concentrations in Healthy Men and Women – Results from the KarMeN Study
Associations of Diet and Plasma BCAA Concentrations in Healthy Men and Women – Results from the KarMeN Study Open
Diet is the only source of the essential branched-chain amino acids (BCAA) isoleucine, leucine and valine. High plasma concentrations of these amino acids are discussed as risk factors for the onset of several diseases such as type 2 diabe…
View article: High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach
High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach Open
High-intensity interval training (HIIT) is known to improve performance and skeletal muscle energy metabolism. However, whether the body’s adaptation to an exhausting short-term HIIT is reflected in the resting human metabolome has not bee…
View article: Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies Open
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by met…
View article: Postprandial metabolic responses to ingestion of bovine glycomacropeptide compared to a whey protein isolate in prediabetic volunteers
Postprandial metabolic responses to ingestion of bovine glycomacropeptide compared to a whey protein isolate in prediabetic volunteers Open
View article: Metabolite profiles evaluated, according to sex, do not predict resting energy expenditure and lean body mass in healthy non-obese subjects
Metabolite profiles evaluated, according to sex, do not predict resting energy expenditure and lean body mass in healthy non-obese subjects Open
View article: Dietary Pattern and Plasma BCAA-Variations in Healthy Men and Women—Results from the KarMeN Study
Dietary Pattern and Plasma BCAA-Variations in Healthy Men and Women—Results from the KarMeN Study Open
Branched-chain amino acids (BCAA) in plasma are discussed as risk factors for the onset of several diseases. Information about the contribution of the overall diet to plasma BCAA concentrations is controversial. Our objective was to invest…
View article: Metabolite patterns predicting sex and age in participants of the Karlsruhe Metabolomics and Nutrition (KarMeN) study
Metabolite patterns predicting sex and age in participants of the Karlsruhe Metabolomics and Nutrition (KarMeN) study Open
Physiological and functional parameters, such as body composition, or physical fitness are known to differ between men and women and to change with age. The goal of this study was to investigate how sex and age-related physiological condit…
View article: Untargeted NMR Spectroscopic Analysis of the Metabolic Variety of New Apple Cultivars
Untargeted NMR Spectroscopic Analysis of the Metabolic Variety of New Apple Cultivars Open
Metabolome analyses by NMR spectroscopy can be used in quality control by generating unique fingerprints of different species. Hundreds of components and their variation between different samples can be analyzed in a few minutes/hours with…
View article: The Karlsruhe Metabolomics and Nutrition (KarMeN) Study: Protocol and Methods of a Cross-Sectional Study to Characterize the Metabolome of Healthy Men and Women
The Karlsruhe Metabolomics and Nutrition (KarMeN) Study: Protocol and Methods of a Cross-Sectional Study to Characterize the Metabolome of Healthy Men and Women Open
German Clinical Trials Register DRKS00004890; https://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do? navigationId=trial.HTML&TRIAL_ID=DRKS00004890 (Archived by WebCite at http://www.webcitation.org/6iyM8dMtx).
View article: Age-Related Changes of Plasma Bile Acid Concentrations in Healthy Adults—Results from the Cross-Sectional KarMeN Study
Age-Related Changes of Plasma Bile Acid Concentrations in Healthy Adults—Results from the Cross-Sectional KarMeN Study Open
Bile acids (BA) play an important role in lipid metabolism. They facilitate intestinal lipid absorption, and BA synthesis is the main catabolic pathway for cholesterol. The objective of this study was to investigate associations of age, se…
View article: Metabolic Responses of Healthy or Prediabetic Adults to Bovine Whey Protein and Sodium Caseinate Do Not Differ
Metabolic Responses of Healthy or Prediabetic Adults to Bovine Whey Protein and Sodium Caseinate Do Not Differ Open