Manuela Kellner
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View article: LPS-induced Acute Lung Injury Involves NF-κB–mediated Downregulation of SOX18
LPS-induced Acute Lung Injury Involves NF-κB–mediated Downregulation of SOX18 Open
One of the early events in the progression of LPS-mediated acute lung injury in mice is the disruption of the pulmonary endothelial barrier resulting in lung edema. However, the molecular mechanisms by which the endothelial barrier becomes…
View article: A combined method for correlative 3D imaging of biological samples from macro to nano scale
A combined method for correlative 3D imaging of biological samples from macro to nano scale Open
Correlative analysis requires examination of a specimen from macro to nano scale as well as applicability of analytical methods ranging from morphological to molecular. Accomplishing this with one and the same sample is laborious at best, …
View article: Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation
Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation Open
Vascular cell hyperproliferation and metabolic reprogramming contribute to the pathophysiology of pulmonary arterial hypertension (PAH). An important cause of PAH in children with congenital heart disease (CHD) is increased pulmonary blood…
View article: Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70–Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells
Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70–Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells Open
Asymmetric dimethylarginine (ADMA) induces the mitochondrial translocation of endothelial nitric oxide synthase (eNOS) through the nitration-mediated activation of Akt1. However, it is recognized that the activation of Akt1 requires phosph…
View article: Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization
Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization Open
Lysophosphatidic acid (LPA) signaling through one of its receptors, LPA1, contributes to both the development and the pathological remodeling after injury of many organs. Because we found previously that LPA-LPA1 signaling contributes to p…
View article: Correlating 3D morphology with molecular pathology: fibrotic remodelling in human lung biopsies
Correlating 3D morphology with molecular pathology: fibrotic remodelling in human lung biopsies Open
Assessing alterations of the parenchymal architecture is essential in understanding fibrosing interstitial lung diseases. Here, we present a novel method to visualise fibrotic remodelling in human lungs and correlate morphological three-di…
View article: Method for 3D Airway Topology Extraction
Method for 3D Airway Topology Extraction Open
In lungs the number of conducting airway generations as well as bifurcation patterns varies across species and shows specific characteristics relating to illnesses or gene variations. A method to characterize the topology of the mouse airw…