Manuela Neumann
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View article: P05.19.A CLINICAL OUTCOME OF BIOMARKER-GUIDED THERAPIES IN ADULT NEURO-ONCOLOGY PATIENTS: AN UPDATE FROM THE TÜBINGEN MOLECULAR TUMOR BOARD COHORT
P05.19.A CLINICAL OUTCOME OF BIOMARKER-GUIDED THERAPIES IN ADULT NEURO-ONCOLOGY PATIENTS: AN UPDATE FROM THE TÜBINGEN MOLECULAR TUMOR BOARD COHORT Open
BACKGROUND Molecular profiling and target decision in the Molecular Tumor Board (MTB), within structured networks such as the Centers for Personalized Medicine (CPM), have broadened therapeutic options for neuro-oncology patients. Here, we…
View article: Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U
Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U Open
Atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions (aFTLD-U) is a rare cause of frontotemporal lobar degeneration (FTLD), characterized postmortem by neuronal inclusions of the FET family of proteins (FTLD-FET). …
View article: Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing Open
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide assoc…
View article: TDP-43 toxic gain of function links ALS, FTD and Alzheimer's Disease through splicing dysregulation
TDP-43 toxic gain of function links ALS, FTD and Alzheimer's Disease through splicing dysregulation Open
Loss of nuclear TDP-43 splicing activity is a common feature across neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but its relevance to Alzheimer's disease (AD) remain…
View article: Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health
Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health Open
Background Genetic variation in Transmembrane protein 106B (TMEM106B) is known to influence the risk and presentation in several neurodegenerative diseases and modifies healthy aging. While evidence from human studies suggests that the ris…
View article: Case report: Behavioral variant FTD confounding a language variant FTD in a case of PSP-CBS
Case report: Behavioral variant FTD confounding a language variant FTD in a case of PSP-CBS Open
Frontotemporal dementia (FTD) occurs in two main clinical subtypes, which can transition into one another: the behavioral variant (bvFTD) and the language variant (primary progressive aphasia; PPA). It is common for the latter, as primary …
View article: Frequency and neuropathology of HTT repeat expansions in FTD/ALS: co-existence rather than causation
Frequency and neuropathology of HTT repeat expansions in FTD/ALS: co-existence rather than causation Open
View article: Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology
Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology Open
View article: Pharmacotherapy of motor symptoms in early and mid-stage Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology
Pharmacotherapy of motor symptoms in early and mid-stage Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology Open
View article: Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline “Parkinson’s disease” of the German Society of Neurology
Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline “Parkinson’s disease” of the German Society of Neurology Open
View article: Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care
Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care Open
View article: Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing
Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing Open
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide assoc…
View article: Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology)
Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology) Open
View article: Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS Open
View article: MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study
MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study Open
Wellcome Trust, Rotha Abraham Trust, Brain Research UK, the Dolby Fund, Dementia Research Institute (Medical Research Council), US National Institutes of Health, and the Mayo Clinic Foundation.
View article: A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes
A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes Open
View article: Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA
Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA Open
The expanded hexanucleotide GGGGCC repeat mutation in the C9orf72 gene is the main genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Under one disease mechanism, sense and antisense transcripts of the repeat are p…
View article: Psychotic symptoms in frontotemporal dementia with TDP‐43 tend to be associated with type B pathology
Psychotic symptoms in frontotemporal dementia with TDP‐43 tend to be associated with type B pathology Open
Aims Psychotic symptoms are increasingly recognized as a distinguishing clinical feature in patients with dementia due to frontotemporal lobar degeneration with TDP‐43 pathology (FTLD‐TDP). Within this group, carriers of the C9orf72 repeat…
View article: AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies
AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies Open
Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies target…
View article: C9ORF72 knockdown triggers FTD-like symptoms and cell pathology in mice
C9ORF72 knockdown triggers FTD-like symptoms and cell pathology in mice Open
The GGGGCC intronic repeat expansion within C9ORF72 is the most common genetic cause of ALS and FTD. This mutation results in toxic gain of function through accumulation of expanded RNA foci and aggregation of abnormally translated dipepti…
View article: Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD
Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD Open
Effective therapies are urgently needed to safely target TDP-43 pathology as it is closely associated with the onset and development of devastating diseases such as frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) and amy…
View article: Correction to: Accumulation of TMEM106B C‑terminal fragments in neurodegenerative disease and aging
Correction to: Accumulation of TMEM106B C‑terminal fragments in neurodegenerative disease and aging Open
View article: Clinical outcome of biomarker-guided therapies in adult patients with tumors of the nervous system
Clinical outcome of biomarker-guided therapies in adult patients with tumors of the nervous system Open
Background The clinical utility of molecular profiling and targeted therapies for neuro-oncology patients outside of clinical trials is not established. We aimed at investigating feasibility and clinical utility of molecular profiling and …
View article: LATE-NC staging in routine neuropathologic diagnosis: an update
LATE-NC staging in routine neuropathologic diagnosis: an update Open
View article: Common Variants Near <scp>ZIC1</scp> and <scp>ZIC4</scp> in Autopsy‐Confirmed Multiple System Atrophy
Common Variants Near <span>ZIC1</span> and <span>ZIC4</span> in Autopsy‐Confirmed Multiple System Atrophy Open
Background Multiple System Atrophy is a rare neurodegenerative disease with alpha‐synuclein aggregation in glial cytoplasmic inclusions and either predominant olivopontocerebellar atrophy or striatonigral degeneration, leading to dysautono…
View article: Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43
Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43 Open
View article: Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.
Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Open
Trans-activation response DNA-binding protein of 43 kDa (TDP-43) regulates RNA processing and forms neuropathological aggregates in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Investigating TDP-43 pos…
View article: Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near <i>ZIC1</i> and <i>ZIC4</i>
Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near <i>ZIC1</i> and <i>ZIC4</i> Open
Multiple System Atrophy is a rare neurodegenerative disease with alpha-synuclein aggregation in glial cytoplasmic inclusions and either predominant olivopontocerebellar atrophy or striatonigral degeneration, leading to dysautonomia, parkin…
View article: Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions
Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions Open
View article: Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases
Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases Open
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders, often considered as the extreme manifestations of a disease spectrum, as they share similar pathomechanisms. In…