Explanipedia

Investigating the role of the histone variant macroH2A1.1 in autism spectrum disorder: a study in mice prenatally exposed to valproate Open

Ilaria Coppola, Valentina Chiodi, Anna Maria Tartaglione, Nunzia La Maida, Alessandro Di Giorgi , et al. · 2024

Spontaneous Pneumothorax Secondary to Bullous Lung Emphysema Positive for Cannabinoids upon Toxicological Examination Open

Mario Bisconti, Angela De Palma, Roberta Pacifici, Maria Concetta Rotolo, Simona Pichini , et al. · 2023

Cannabis can be related to respiratory diseases, but the relationship between smoking marijuana and the development of a pneumothorax has scarcely been investigated. We aimed to analyze, in patients with a history of cannabis smoking abuse…

Supplementary Methods, Figures 1-9 from A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis Open

Harald F. Langer, Valeria V. Orlova, Changping Xie, Sunil C. Kaul, Darius Schneider , et al. · 2023

Supplementary Methods, Figures 1-9 from A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis

Supplementary Methods, Figures 1-9 from A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis Open

Harald F. Langer, Valeria V. Orlova, Changping Xie, Sunil C. Kaul, Darius Schneider , et al. · 2023

Supplementary Methods, Figures 1-9 from A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis

Data from A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis Open

Harald F. Langer, Valeria V. Orlova, Changping Xie, Sunil C. Kaul, Darius Schneider , et al. · 2023

Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identi…

Data from A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis Open

Harald F. Langer, Valeria V. Orlova, Changping Xie, Sunil C. Kaul, Darius Schneider , et al. · 2023

Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identi…

Synthetic cannabinoids use in a sample of opioid-use disorder patients Open

Maria Alías-Ferri, Manuela Pellegrini, Emilia Marchei, Roberta Pacifici, Maria Concetta Rotolo , et al. · 2022

Cannabis is the most widely consumed illegal drug in the world and synthetic cannabinoids are increasingly gaining popularity and replacing traditional cannabis. These substances are a type of new psychoactive substance that mimics the can…

New Psychoactive Substances Consumption in Opioid-Use Disorder Patients Open

Maria Alías-Ferri, Manuela Pellegrini, Emilia Marchei, Roberta Pacifici, Maria Concetta Rotolo , et al. · 2022

(1) Background: Since the beginning of the 21st century, the large number and wide chemical variety of new psychoactive substances (NPS) that enter the market every year has become a public health problem. Given the rapidity with which the…

New Synthetic Opioids Use among Patients in Treatment for an Opioid Use Disorder in Barcelona Open

Maria Alías-Ferri, Emilia Marchei, Roberta Pacifici, Simona Pichini, Manuela Pellegrini , et al. · 2022

Introduction: New synthetic opioids (NSO), a class of new psychoactive substances (NPS), have recently emerged and pose an upcoming global public health challenge. The effects produced by NSO are similar to those from morphin…

Turmeric (Curcuma longa L.) food supplements and hepatotoxicity: an integrated evaluation approach. Open

Francesca Menniti‐Ippolito, Ilaria Ippoliti, Augusto Alberto Pastorelli, Ilaria Altieri, F Scalise , et al. · 2021

On the basis of the results of all the activities performed by multidisciplinary group, regulatory intervention was taken. This study highlights the importance of developing an integrated evaluation approach for the evaluation of the adver…

Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study Open

Lucía Martínez de Soto, Nunzia La Maida, Esther Papaseit, Clara Pérez‐Mañá, Lourdes Poyatos , et al. · 2021

Synthetic cannabinoids (SCs) are a group of new psychoactive drugs used recreationally with potential health risks. They are monitored by the EU Early Warning System since 2010 due to severe adverse effects on consumers. JWH-122 and JWH-21…

Hair Testing for Classic Drugs of Abuse to Monitor Cocaine Use Disorder in Patients Following Transcranial Magnetic Stimulation Protocol Treatment Open

Maria Concetta Rotolo, Roberta Pacifici, Manuela Pellegrini, Stefano Cardullo, Luis J. Gómez Pérez , et al. · 2021

In recent years, hair has become an alternative biological specimen for drug testing in the fields of forensic and clinical toxicology. The advantages of hair testing include larger detection windows (months/years), depending on the length…

Ultra-High Performance Liquid Chromatography-High Resolution Mass Spectrometry and High-Sensitivity Gas Chromatography-Mass Spectrometry Screening of Classic Drugs and New Psychoactive Substances and Metabolites in Urine of Consumers Open

Emilia Marchei, Maria Alías-Ferri, Marta Torrens, Magı́ Farré, Roberta Pacifici , et al. · 2021

The use of the new psychoactive substances is continuously growing and the implementation of accurate and sensible analysis in biological matrices of users is relevant and fundamental for clinical and forensic purposes. Two different analy…

Acute Pharmacological Effects and Oral Fluid Biomarkers of the Synthetic Cannabinoid UR-144 and THC in Recreational Users Open

Nunzia La Maida, Esther Papaseit, Lucía Martínez de Soto, Clara Pérez‐Mañá, Lourdes Poyatos , et al. · 2021

Synthetic cannabinoids (SCs) are one of the most frequent classes of new psychoactive substances monitored by the EU Early Warning System and World Health Organization. UR-144 is a SC with a relative low affinity for the CB1 receptor with …

Monitoring use of pesticides in the pistoia area Open

Angela Veraldi, Michela Balduini, Ljiljana Kovacic, Benedetta Lenzi, Massimo Barbani , et al. · 2021

Background. The surveys of pesticides in the areas of Pistoia and Valdinievole characterized by nursery and floriculture industry. Objectives. To determine types and quantities of pesticides used by a sample of floriculture and nursery com…

Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS Open

Nunzia La Maida, Manuela Pellegrini, Esther Papaseit, Clara Pérez‐Mañá, Lourdes Poyatos , et al. · 2020

The consumption of synthetic cannabinoids (SCs) has significantly increased in the last decade and the analysis of SCs and their metabolites in human specimens is gaining interest in clinical and forensic toxicology. A pilot study has been…

UHPLC-HRMS and GC-MS Screening of a Selection of Synthetic Cannabinoids and Metabolites in Urine of Consumers Open

Manuela Pellegrini, Emilia Marchei, Esther Papaseit, Magı́ Farré, Simona Zaami · 2020

Background and Objectives: The use of synthetic cannabinoids has increased around the world. As a result, the implementation of accurate analysis in human biological matrices is relevant and fundamental. Two different analytical technologi…

Is “light cannabis” really light? Determination of cannabinoids content in commercial products Open

Emilia Marchei, Roberta Tittarelli, Manuela Pellegrini, Maria Concetta Rotolo, Roberta Pacifici , et al. · 2020

In the recent past, both the European Regulations No. 1307/2013 [1] and No. 2017/1155 [2] and the Italian law No. 242/2016 have allowed the cultivation of cannabis plant varieties containing up to 0.2% (with a tolerance of up to 0.6%) of t…

Development and Validation of a Method for the Analysis of Bisoprolol and Atenolol in Human Bone Open

Lucía Fernández-López, Manuela Pellegrini, Maria Concetta Rotolo, Aurelio Luna Maldonado, María Falcón Romero , et al. · 2019

A method based on gas chromatography–mass spectrometry (GC–MS) is described for the determination of bisoprolol and atenolol in human bone. After the addition of lobivolol as internal standard, pulverized samples were incubated in acetonit…

Atrophy, oxidative switching and ultrastructural defects in skeletal muscle of Ataxia Telangiectasia mouse model Open

Valentina Tassinari, Vincenzo De Gennaro, Gina La Sala, Daniela Marazziti, Giulia Bolasco , et al. · 2019

Ataxia Telangiectasia is a rare, multi system disease caused by ATM kinase deficiency. Atm knockout mice recapitulate premature aging, immunodeficiency, cancer predisposition, growth retardation and motor defects but not cerebellar neurode…

Developmental Timing of Mammalian Limb Diversification Open

Karen E. Sears, N. Anthwal, Alice Mouton, Tom F. Su, Fung T. Lay , et al. · 2019

peer reviewed

Cannabinoids determination in bronchoalveolar lavages of cannabis smokers with lung disease Open

Maria Concetta Rotolo, Manuela Pellegrini, Paola Martucci, Raffaela Giacobbe, Angela De Palma , et al. · 2018

Background Cannabis smoke affects the lungs similarly to tobacco smoke, causing symptoms such as increased cough, sputum, hyperinflation and chronic bronchitis. Chronic use can also cause serious lung diseases and airway obstruction. We de…

Correlation between Blood and Oral Fluid Psychoactive Drug Concentrations and Cognitive Impairment in Driving under the Influence of Drugs Open

Francesco Paolo Busardò, Simona Pichini, Manuela Pellegrini, Angelo Montana, Alfredo Fabrizio Lo Faro , et al. · 2017

Multiple aspects of driving performance can be differently affected by illicit drugs, and even if for few of them some dose/concentration dependent impairment has been reported, a wider knowledge on concentration/impairment relationship is…

Recent Trends in Analytical Methods to Determine New Psychoactive Substances in Hair Open

Chrystalla Kyriakou, Manuela Pellegrini, Óscar García‐Algar, Enrico Marinelli, Simona Zaami · 2016

Methods for the determination of NPS in hair are continually emerging to include as many NPS as possible due to the great demand for their detection.

Non-allowed Pharmacologically Active Substances in Physical and Sexual Performance Enhancing Products Open

Manuela Pellegrini, Maria Concetta Rotolo, Francesco Paolo Busardò, Roberta Pacifici, Simona Pichini · 2016

Eventual health hazards caused by the hidden presence of pharmacologically active substances in physical and sexual performance enhancing products are reported.

Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study Open

Roberta Pacifici, Simona Pichini, Silvia Graziano, Manuela Pellegrini, Giuseppina Massaro , et al. · 2015

The electronic cigarette (e-cig) has gained popularity as an aid in smoking cessation programs mainly because it maintains the gestures and rituals of tobacco smoking. However, it has been shown in inexperienced e-cig users that ineffectiv…

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