Manuela Simonetti
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View article: Cellular and Molecular Mechanisms Underlying Pain Chronicity
Cellular and Molecular Mechanisms Underlying Pain Chronicity Open
Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs [...]
View article: Activation of β2-Adrenergic Receptors in Microglia Alleviates Neuropathic Hypersensitivity in Mice
Activation of β2-Adrenergic Receptors in Microglia Alleviates Neuropathic Hypersensitivity in Mice Open
Drugs enhancing the availability of noradrenaline are gaining prominence in the therapy of chronic neuropathic pain. However, underlying mechanisms are not well understood, and research has thus far focused on α2-adrenergic receptors and n…
View article: Activation of β2-adrenergic receptors in microglia alleviates neuropathic hypersensitivity in mice
Activation of β2-adrenergic receptors in microglia alleviates neuropathic hypersensitivity in mice Open
Drugs enhancing the availability of noradrenaline are gaining prominence in the therapy of chronic neuropathic pain. However, underlying mechanisms are not well understood, and research has thus far focused on α2-adrenergic receptors and n…
View article: Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of persistent pain
Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of persistent pain Open
Long-lasting pain stimuli can trigger maladaptive changes in the spinal cord, reminiscent of plasticity associated with memory formation. Metabolic coupling between astrocytes and neurons has been implicated in neuronal plasticity and memo…
View article: Axon Guidance Molecules and Pain
Axon Guidance Molecules and Pain Open
Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community. Developmental mole…
View article: The Macrophage Iron Signature in Health and Disease
The Macrophage Iron Signature in Health and Disease Open
Throughout life, macrophages are located in every tissue of the body, where their main roles are to phagocytose cellular debris and recycle aging red blood cells. In the tissue niche, they promote homeostasis through trophic, regulatory, a…
View article: Spinal Wnt5a Plays a Key Role in Spinal Dendritic Spine Remodeling in Neuropathic and Inflammatory Pain Models and in the Proalgesic Effects of Peripheral Wnt3a
Spinal Wnt5a Plays a Key Role in Spinal Dendritic Spine Remodeling in Neuropathic and Inflammatory Pain Models and in the Proalgesic Effects of Peripheral Wnt3a Open
Wnt signaling represents a highly versatile signaling system, which plays critical roles in developmental morphogenesis as well as synaptic physiology in adult life and is implicated in a variety of neural disorders. Recently, we demonstra…
View article: Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain Open
Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we …