Manus J. Donahue
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View article: Cognitive and Motor Improvements Correlated with Sleep and Activity Following Community-Based Non-contact Boxing in Patients with Parkinson Disease
Cognitive and Motor Improvements Correlated with Sleep and Activity Following Community-Based Non-contact Boxing in Patients with Parkinson Disease Open
Objective To evaluate the feasibility of a 12-week community-based, non-contact rock-steady-boxing (RSB) program in individuals with Parkinson disease (PD) and to assess potential improvements in motor and cognitive functioning after inter…
View article: Parasagittal dural space and arachnoid granulations morphology in pre-clinical and early clinical multiple sclerosis
Parasagittal dural space and arachnoid granulations morphology in pre-clinical and early clinical multiple sclerosis Open
Background: There is limited knowledge on the post-glymphatic structures such as the parasagittal dural (PSD) space and the arachnoid granulations (AGs) in multiple sclerosis (MS). Objectives: To evaluate differences in volume and macromol…
View article: The choroid plexus water density
The choroid plexus water density Open
Purpose To quantify normative ranges and circadian variability of the choroid plexus (ChP) water density in healthy adults. Methods Actigraphy assessments of circadian activity were performed for 5 days in healthy participants ( n = 15; ag…
View article: The <scp>MSA</scp> Atrophy Index (<scp>MSA</scp>‐<scp>AI</scp>): An Imaging Marker for Diagnosis and Clinical Progression in Multiple System Atrophy
The <span>MSA</span> Atrophy Index (<span>MSA</span>‐<span>AI</span>): An Imaging Marker for Diagnosis and Clinical Progression in Multiple System Atrophy Open
Objective Reliable biomarkers are essential for tracking disease progression and advancing treatments for multiple system atrophy (MSA). In this study, we propose the MSA Atrophy Index (MSA‐AI), a novel composite volumetric measure to dist…
View article: The parasagittal dural space of the human brain
The parasagittal dural space of the human brain Open
The historical understanding of CSF production and flow comprises CSF production primarily in the choroid plexus of the first to third ventricles, flow through the aqueduct of Sylvius en route to the fourth ventricle, circulation around th…
View article: The influence of computer-controlled Motorbunny™ device use on sexual health and sleep behaviors
The influence of computer-controlled Motorbunny™ device use on sexual health and sleep behaviors Open
Sleep has gained much attention as a marker of cerebral health, and it is now well-established that sleep becomes disrupted in normal aging and in the setting of neurodegeneration. However, it remains less clear how sleep behaviors can be …
View article: (185) REFERRAL RELATIONSHIPS FOR HOLISTIC SEXUAL HEALTH
(185) REFERRAL RELATIONSHIPS FOR HOLISTIC SEXUAL HEALTH Open
Introduction The physician/sex therapist/sexuality educator referral relationship has the potential to enhance sexual health through a holistic approach to care. This type of business relationship thrives when the participants understand a…
View article: Magnetic resonance imaging to detect tumor hypoxia in brain malignant disease: A systematic review of validation studies
Magnetic resonance imaging to detect tumor hypoxia in brain malignant disease: A systematic review of validation studies Open
View article: Electroencephalogram Electrode and Amplifier Temperature Changes During Routine Anatomical and Functional Magnetic Resonance Imaging Sequences at 3 Tesla
Electroencephalogram Electrode and Amplifier Temperature Changes During Routine Anatomical and Functional Magnetic Resonance Imaging Sequences at 3 Tesla Open
Magnetic resonance imaging (MRI) sequences commonly used in simultaneous electroencephalogram (EEG)-MRI studies include blood oxygenation level-dependent (BOLD) and anatomical T 1 -weighted MRI. Safety and electrode heating profiles for th…
View article: Central Involvement in Pure Autonomic Failure: Insights from Neuromelanin‐Sensitive Magnetic Resonance Imaging and <sup>18</sup>F‐Fluorodopa‐Positron Emission Tomography
Central Involvement in Pure Autonomic Failure: Insights from Neuromelanin‐Sensitive Magnetic Resonance Imaging and <sup>18</sup>F‐Fluorodopa‐Positron Emission Tomography Open
Background Central synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), involve alpha‐synuclein accumulation and dopaminergic cell loss in the substantia nigra (SN) and …
View article: Microstructural grey matter alterations in patients with behavioural variant frontotemporal dementia
Microstructural grey matter alterations in patients with behavioural variant frontotemporal dementia Open
Behavioural variant frontotemporal dementia is characterized by progressive changes to personality and behaviour, yet early detection and disease staging remain challenging. Current clinical neuroimaging relies on visual assessment of atro…
View article: Cerebral vascular shunting and oxygen metabolism in sickle cell disease
Cerebral vascular shunting and oxygen metabolism in sickle cell disease Open
Patients with sickle cell disease (SCD) are at elevated risk of silent cerebral infarcts and strokes; however, they frequently lack established stroke risk factors (eg, macrovascular arterial steno-occlusion) and the mechanisms underlying …
View article: Cerebrovascular reactivity and response times describe recent ischaemic symptomatology in patients with moyamoya
Cerebrovascular reactivity and response times describe recent ischaemic symptomatology in patients with moyamoya Open
Moyamoya is a non-atherosclerotic intracranial steno-occlusive condition that places patients at high risk for ischaemic stroke. Randomized trials of surgical revascularization demonstrating efficacy in ischaemic moyamoya have not been per…
View article: Chronic active lesions preferentially localize in watershed territories in multiple sclerosis
Chronic active lesions preferentially localize in watershed territories in multiple sclerosis Open
Objective Paramagnetic rim lesions (PRLs) are a biomarker of chronic active lesions (CALs), and an important driver of neurological disability in multiple sclerosis (MS). The reason subtending some acute lesions evolvement into CALs is not…
View article: Intravenous arachnoid granulation hypertrophy in patients with Parkinson disease
Intravenous arachnoid granulation hypertrophy in patients with Parkinson disease Open
View article: Detectability of white matter cerebral blood flow using arterial spin labeling MRI in patients with sickle cell disease: Relevance of flow territory, bolus arrival time and hematocrit
Detectability of white matter cerebral blood flow using arterial spin labeling MRI in patients with sickle cell disease: Relevance of flow territory, bolus arrival time and hematocrit Open
Sickle cell disease (SCD) is the most common genetic blood disorder, characterized by red cell hemolysis, anemia, and corresponding increased compensatory cerebral blood flow (CBF). SCD patients are at high risk for cerebral infarcts and C…
View article: Reduced cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with low b-value diffusion weighted imaging
Reduced cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with low b-value diffusion weighted imaging Open
View article: Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan
Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan Open
Background The choroid plexus functions as the blood-cerebrospinal fluid (CSF) barrier, plays an important role in CSF production and circulation, and has gained increased attention in light of the recent elucidation of CSF circulation dys…
View article: Cerebrovascular reactivity dispersion as a new biomarker of recent stroke symptomatology in moyamoya
Cerebrovascular reactivity dispersion as a new biomarker of recent stroke symptomatology in moyamoya Open
Background Moyamoya disease (MMD) is a non-atherosclerotic intracranial steno-occlusive condition placing patients at high risk for ischemic stroke. Direct and indirect surgical revascularization can improve blood flow in MMD; however, ran…
View article: Deep learning segmentation of peri-sinus structures from structural magnetic resonance imaging: validation and normative ranges across the adult lifespan
Deep learning segmentation of peri-sinus structures from structural magnetic resonance imaging: validation and normative ranges across the adult lifespan Open
Background Peri-sinus structures such as arachnoid granulations (AG) and the parasagittal dural (PSD) space have gained much recent attention as sites of cerebral spinal fluid (CSF) egress and neuroimmune surveillance. Neurofluid circulati…
View article: Watershed regions are more susceptible to tissue microstructural injury in multiple sclerosis
Watershed regions are more susceptible to tissue microstructural injury in multiple sclerosis Open
Histopathologic studies report higher concentrations of multiple sclerosis white matter lesions in watershed areas of the brain, suggesting that areas with relatively lower oxygen levels may be more vulnerable to disease. However, it is un…
View article: Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer’s disease
Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer’s disease Open
We report the case of a 79-year-old woman with Alzheimer’s disease who participated in a Phase III randomized controlled trial called CLARITY-AD testing the experimental drug lecanemab. She was randomized to the placebo group and subsequen…
View article: Cerebral hemodynamic changes after haploidentical hematopoietic stem cell transplant in adults with sickle cell disease
Cerebral hemodynamic changes after haploidentical hematopoietic stem cell transplant in adults with sickle cell disease Open
Preliminary evidence from a series of 4 adults with sickle cell disease (SCD) suggests that hematopoietic stem cell transplant (HSCT) improves cerebral hemodynamics. HSCT largely normalizes cerebral hemodynamics in children with SCD. We te…
View article: Choroid plexus vascular reactivity in moyamoya: Implications for choroid plexus regulation in ischemic stress
Choroid plexus vascular reactivity in moyamoya: Implications for choroid plexus regulation in ischemic stress Open
Background and Purpose Choroid plexus (ChP) hyperemia has been observed in patients with intracranial vasculopathy and to reduce following successful surgical revascularization. This observation may be attributable to impaired vascular res…
View article: Accentuated Paralimbic and Reduced Mesolimbic D<sub>2/3</sub>-Impulsivity Associations in Parkinson's Disease
Accentuated Paralimbic and Reduced Mesolimbic D<sub>2/3</sub>-Impulsivity Associations in Parkinson's Disease Open
Impulsivity is a behavioral trait that is elevated in many neuropsychiatric disorders. Parkinson's disease (PD) patients can exhibit a specific pattern of reward-seeking impulsive-compulsive behaviors (ICBs), as well as more subtle changes…
View article: National survey of patient symptoms and therapies among 707 women with a lipedema phenotype in the United States
National survey of patient symptoms and therapies among 707 women with a lipedema phenotype in the United States Open
Background: National survey data exploring the patient experience with lipedema are lacking. Methods: We conducted national surveys from 2016 to 2022 of women with lipedema as well as female controls. Surveys collected information on sympt…
View article: Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial
Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial Open
View article: Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan
Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan Open
Background : The choroid plexus functions as the blood-cerebrospinal fluid barrier, plays an important role in neurofluid production and circulation, and has gained increased attention in light of the recent elucidation of neurofluid circu…
View article: In vivo lymph node <scp>CEST‐Dixon MRI</scp> in breast cancer patients with metastatic lymph node involvement
In vivo lymph node <span>CEST‐Dixon MRI</span> in breast cancer patients with metastatic lymph node involvement Open
Purpose Axillary lymph nodes (LNs) often present a reservoir for metastatic breast cancer, yet metastatic LN involvement cannot be discerned definitively using diagnostic imaging. This study investigated whether in vivo CEST may discrimina…
View article: Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings
Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings Open
BACKGROUND: Parkinson’s disease is characterized by dopamine-responsive symptoms as well as aggregation and accumulation of a-synuclein protofibrils. New diagnostic methods assess a-synuclein aggregation characteristics from cerebrospinal …