Manwoo Lee
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View article: Initial Dosimetry of a Prototype Ultra-High Dose Rate Electron-Beam Irradiator for FLASH RT Preclinical Studies
Initial Dosimetry of a Prototype Ultra-High Dose Rate Electron-Beam Irradiator for FLASH RT Preclinical Studies Open
Hyun Kim, Heuijin Lim, Sang Koo Kang, Sang Jin Lee, Tae Woo Kang, Seung Wook Kim, Wung-Hoa Park, Manwoo Lee, Kyoung Won Jang, Dong Hyeok Jeong. Progress in Medical Physics 2023;34:33-9. https://doi.org/10.14316/pmp.2023.34.3.33
View article: Tolerance of mouse cardiac tissue to the maximum dose of FLASH versus conventional radiation
Tolerance of mouse cardiac tissue to the maximum dose of FLASH versus conventional radiation Open
Background: FLASH radiation (average dose rate: >40 Gy/s) delivers ultrahigh doses of radiation, which are several times higher than the clinically used conventional (CONV) radiation doses (average dose rate: >5 Gy/min). This study aimed t…
View article: Mouse cardiac tissue received greater protection from and had better tolerance to the maximum dose of FLASH versus conventional radiation
Mouse cardiac tissue received greater protection from and had better tolerance to the maximum dose of FLASH versus conventional radiation Open
Radiation therapy is used to treat patients with various types of cancer by killing tumor cells or inhibiting their growth. However, conventional radiation (CONV) not only shrinks the tumor, but also irradiates the surrounding normal tissu…
View article: Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons
Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons Open
Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR…
View article: Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation
Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation Open
Background To assess the radiosensitivity of liver tumors harboring different genetic mutations, mouse liver tumors were generated in vivo through the hydrodynamic injection of clustered regularly interspaced short palindromic repeat/caspa…
View article: Optical Filter-Embedded Fiber-Optic Radiation Sensor for Ultra-High Dose Rate Electron Beam Dosimetry
Optical Filter-Embedded Fiber-Optic Radiation Sensor for Ultra-High Dose Rate Electron Beam Dosimetry Open
FLASH radiotherapy is an emerging radiotherapy technique used to spare normal tissues. It employs ultra-high dose rate radiation beams over 40 Gy/s, which is significantly higher than those of conventional radiotherapy. In this study, a fi…
View article: Risk factors associated with surveillance loss after endoscopic submucosal dissection in patients with gastric neoplasm
Risk factors associated with surveillance loss after endoscopic submucosal dissection in patients with gastric neoplasm Open
Dysplasia, old age, and the American Society of Anesthesiologists physical status 1 were associated with surveillance loss in patients who underwent gastric endoscopic submucosal dissection. It could be helpful to proactively monitor patie…
View article: High-Dose-Rate Electron-Beam Dosimetry Using an Advanced Markus Chamber with Improved IonRecombination Corrections
High-Dose-Rate Electron-Beam Dosimetry Using an Advanced Markus Chamber with Improved IonRecombination Corrections Open
Purpose: In ionization-chamber dosimetry for high-dose-rate electron beams一above 20 mGy/pulse一the ion-recombination correction methods recommended by the International Atomic Energy Agency (IAEA) and the American Association of Physicists …
View article: Development and Evaluation of Monoxide Based Flexible Skin Dosimeter for Radiotherapy at Photon Energies
Development and Evaluation of Monoxide Based Flexible Skin Dosimeter for Radiotherapy at Photon Energies Open
Radiation therapy uses high-energy radiation that can cause various side effects depending on the patient's exposure. In particular, side effects occur in the skin due to its radiation exposure to reach the target volume. Therefore, side e…
View article: Calsyntenin 1 mRNA expression sensitivity to ionizing radiation in human hepatocytes and carcinoma cells and blood cells of BALB/c mice
Calsyntenin 1 mRNA expression sensitivity to ionizing radiation in human hepatocytes and carcinoma cells and blood cells of BALB/c mice Open
Whether calsyntenin 1 (CLSTN1) and serine hydroxymethyltransferase 2 (SHMT2) are sensitive to low-dose ionizing radiation (LDIR) has not yet been defined. Therefore, here, we aimed to investigate changes in gene expression in hepatic cell …
View article: Development of a Wide Dose-Rate Range Electron Beam Irradiation System for Pre-Clinical Studies and Multi-Purpose Applications Using a Research Linear Accelerator
Development of a Wide Dose-Rate Range Electron Beam Irradiation System for Pre-Clinical Studies and Multi-Purpose Applications Using a Research Linear Accelerator Open
Kyoung Won Jang , Manwoo Lee , Heuijin Lim , Sang Koo Kang , Sang Jin Lee , Jung Kee Kim , Young Min Moon , Jin Young Kim , Dong Hyeok Jeong. Progress in Medical Physics 2020;31:9-19. https://doi.org/10.14316/pmp.2020.31.2.9
View article: Measurement of Switching Performance of Pixelated Silicon Sensor Integrated with Field Effect Transistor
Measurement of Switching Performance of Pixelated Silicon Sensor Integrated with Field Effect Transistor Open
Silicon shows very high detection efficiency for low-energy photons, and the silicon pixel sensor provides high spatial resolution. Pixelated silicon sensors facilitate the direct detection of low-energy X-ray radiation. In this study, we …
View article: Electron Energy Distribution for a Research Electron LINAC
Electron Energy Distribution for a Research Electron LINAC Open
The energy distribution was calculated for an electron beam from an electron linear accelerator developed for medical applications using computational methods. The depth dose data for monoenergetic electrons from 0.1 MeV to 8.0 MeV were ca…
View article: Photonuclear Studies for the Isomeric Yield Ratios in the Production of<sup>nat</sup>Fe(γ,xnp)<sup>52m,g</sup>Mn with 50-,60-, and 70-MeV Bremsstrahlung
Photonuclear Studies for the Isomeric Yield Ratios in the Production of<sup>nat</sup>Fe(γ,xnp)<sup>52m,g</sup>Mn with 50-,60-, and 70-MeV Bremsstrahlung Open
The isomeric yield ratios in the production of natFe(γ,xnp)52m,gMn have been measured with photonuclear reactions. The high purity natural Fe metallic foils were used and irradiated with bremsstrahlung beams of end point energy 50-, 60-, a…
View article: Measurement of Energy Parameters for Electron Gun Heater Currents and Output Dose Rate for Electron Beams from a Prototype Linac
Measurement of Energy Parameters for Electron Gun Heater Currents and Output Dose Rate for Electron Beams from a Prototype Linac Open
The dosimetric characteristics were experimentally evaluated for electron beams from the prototype linac developed for radiotherapy units. This paper focuses on the electron beam output and energy variations as a function of electron gun h…