Manya Yu
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View article: Paeoniflorin inhibits angiogenesis in multiple myeloma by decreasing the MEF2A level to downregulate the expression of lncRNA MALAT1 within exosomes
Paeoniflorin inhibits angiogenesis in multiple myeloma by decreasing the MEF2A level to downregulate the expression of lncRNA MALAT1 within exosomes Open
Angiogenesis is a pivotal mechanism driving tumor proliferation, and the epigenetic regulation of angiogenesis represents a cutting-edge area of current research in multiple myeloma (MM). High-throughput sequencing was carried out to detec…
View article: Case Report: Ablation as novel x therapy in the regimen for frail hematological malignancies with extramedullary lesion
Case Report: Ablation as novel x therapy in the regimen for frail hematological malignancies with extramedullary lesion Open
Hematological diseases, as a category of malignant tumors originating from the hematopoietic system, have long relied on treatments such as chemotherapy, radiotherapy, and hematopoietic stem cell transplantation. However, challenges remain…
View article: Study on the Mechanism of Zhigancao Decoction Regulating Mirna-21/ Tlr4 Associated Apoptosis Via Mettl3 Mediated M6a Methylation Modification To Improve Doxorubicin-Induced Myocardial Apoptosis
Study on the Mechanism of Zhigancao Decoction Regulating Mirna-21/ Tlr4 Associated Apoptosis Via Mettl3 Mediated M6a Methylation Modification To Improve Doxorubicin-Induced Myocardial Apoptosis Open
View article: Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity
Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity Open
This study showed that ISL may exert cardioprotective role restoring BNIP3-mediated mitophagy by targeting TRDMT1 to alleviate DOX-induced macro-autophagy-dependent protein homeostasis and acquired blocking of mitophagy, providing a new id…
View article: m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma
m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma Open
N1-methyladenosine (m1A), a methylation of RNA, is gaining attention for its role in diverse biological processes. However, the potential roles of m1A regulatory-mediated methylation modifications in multiple myeloma (MM) remain…
View article: Aberrant NSUN2-mediated m5C modification of exosomal LncRNA MALAT1 induced RANKL-mediated bone destruction in multiple myeloma
Aberrant NSUN2-mediated m5C modification of exosomal LncRNA MALAT1 induced RANKL-mediated bone destruction in multiple myeloma Open
View article: Synergistic effect of FOXM1 and BCL-2 inhibition in a preclinical treatment study on multiple myeloma
Synergistic effect of FOXM1 and BCL-2 inhibition in a preclinical treatment study on multiple myeloma Open
View article: Paeoniflorin inhibiting the angiogenesis via decreasing MEF2A level to downregulate the expression of LncRNA MALAT1 of exosomes in multiple myeloma
Paeoniflorin inhibiting the angiogenesis via decreasing MEF2A level to downregulate the expression of LncRNA MALAT1 of exosomes in multiple myeloma Open
Background Angiogenesis is a pivotal mechanism driving tumor proliferation, and the epigenetic regulation of angiogenesis represents a cutting-edge area of current research in multiple myeloma (MM). Methods High-throughput sequencing was c…
View article: Identification of an angiogenesis-related risk score model for survival prediction and immunosubtype screening in multiple myeloma
Identification of an angiogenesis-related risk score model for survival prediction and immunosubtype screening in multiple myeloma Open
This study revealed that angiogenesis is significantly related to MM patient prognosis and immune phenotype. Evaluating the AAG signature was conducive to predicting patient response to immunotherapy and guiding more efficacious immunother…
View article: PB2592: THERAPEUTIC PLASMA EXCHANGE THERAPY SUPPORT FOR COVID-19 WITH NEUROLOGICAL COMPLICATIONS: A CASE REPORT
PB2592: THERAPEUTIC PLASMA EXCHANGE THERAPY SUPPORT FOR COVID-19 WITH NEUROLOGICAL COMPLICATIONS: A CASE REPORT Open
Topic: 30. Infections in hematology (incl. supportive care/therapy) Background: Therapeutic plasma exchange (TPE) has been used as an alternative treatment in severe sepsis for several decades. Several groups, including the US Food and Dru…
View article: P843: ABERRANT M5C MODIFICATION OF LNCRNA MALAT1 IS ASSOCIATED WITH BONE LESIONS FORMATION IN MULTIPLE MYELOMA
P843: ABERRANT M5C MODIFICATION OF LNCRNA MALAT1 IS ASSOCIATED WITH BONE LESIONS FORMATION IN MULTIPLE MYELOMA Open
Topic: 13. Myeloma and other monoclonal gammopathies - Biology & Translational Research Background: MM is still an incurable disease and osteoclast-mediated bone destruction is a hallmark. Existing agents effectively reduce the number of o…
View article: Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy
Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy Open
The present study confirmed that paeoniflorin significantly ameliorated peripheral neuropathy (PN) caused by bortezomib, possibly by reducing IL6 levels to regulate PARKIN-mediated mitochondrial autophagy and mitochondrial damage.
View article: M1A Regulator-Mediated Methylation Modification And Gene Signatures And Their Prognostic Value In Multiple Myeloma
M1A Regulator-Mediated Methylation Modification And Gene Signatures And Their Prognostic Value In Multiple Myeloma Open
Introduction: N1‑methyladenosine (m1A), a methylation modification on RNA, is gaining attention for its role across diverse biological processes. However, the potential roles of m1A regulator-mediated methylation modification in multiple m…
View article: A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis
A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis Open
The importance of angiogenesis in multiple myeloma (MM) is unquestionable; however, to date, the success of antiangiogenic therapies has been fairly limited. Exosomal circular RNAs (circRNAs) have been proven to be pivotal players in angio…